[en] This paper summarizes the present status of the researches conducted with [(18)F]4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido ]ethyl]-piperazine known as [(18)F]p-MPPF, a new 5-HT(1A) antagonist for the study of the serotonergic neurotransmission with positron emission tomography (PET). This includes chemistry, radiochemistry, animal data (rats, cats, and monkeys) with autoradiography and PET, human data with PET, toxicity, and metabolism.
Research center :
INSERM/CFB GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others Radiology, nuclear medicine & imaging
Author, co-author :
Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron
Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Aerts, Joël ; Université de Liège - ULiège > Centre de recherches du cyclotron
Lacan, Goran; UCLA School of Medicine > Molecular and Medical Pharmacology
Rubins, D.; UCLA School of Medicine > Molecular and Medical Pharmacology
Melega, William P.; UCLA School of Medicine > Molecular and Medical Pharmacology
Brihaye, Claude; Université de Liège - ULiège > Centre de recherches du cyclotron
Degueldre, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Fuchs, Sonia; Université de Liège - ULiège > Centre de recherches du cyclotron
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Maquet, Pierre ; Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron
Damhaut, Philippe; UCLA School of Medicine > Molecular and Medical Pharmacology
Weissmann, D.
Le Bars, Didier; Centre d'Exploration et de Recherche Médicales par Émission de Positons - CERMEP (Lyon)
Pujol, Jean-François
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
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