Article (Scientific journals)
Correlation between resting state fMRI total neuronal activity and PET metabolism in healthy controls and patients with disorders of consciousness
Soddu, Andrea; Gomez, Francisco; Heine, Lizette et al.
2016In Brain and Behavior, 6 (1), p. 1-15
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Keywords :
disorders of consciousness; FDG-PET; fMRI; ICA; metabolism; resting state
Abstract :
[en] Introduction: The mildly invasive 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging technique to measure ‘resting state’ cerebral metabolism. This technique made it possible to assess changes in metabolic activity in clinical applications, such as the study of severe brain injury and disorders of consciousness. Objective: We assessed the possi- bility of creating functional MRI activity maps, which could estimate the rela- tive levels of activity in FDG-PET cerebral metabolic maps. If no metabolic absolute measures can be extracted, our approach may still be of clinical use in centers without access to FDG-PET. It also overcomes the problem of recogniz- ing individual networks of independent component selection in functional mag- netic resonance imaging (fMRI) resting state analysis. Methods: We extracted resting state fMRI functional connectivity maps using independent component analysis and combined only components of neuronal origin. To assess neu- ronality of components a classification based on support vector machine (SVM) was used. We compared the generated maps with the FDG-PET maps in 16 healthy controls, 11 vegetative state/unresponsive wakefulness syndrome patients and four locked-in patients. Results: The results show a significant similarity with q = 0.75  0.05 for healthy controls and q = 0.58  0.09 for vegetative state/unresponsive wakefulness syndrome patients between the FDG- PET and the fMRI based maps. FDG-PET, fMRI neuronal maps, and the conjunction analysis show decreases in frontoparietal and medial regions in vegetative patients with respect to controls. Subsequent analysis in locked-in syndrome patients produced also consistent maps with healthy controls. Conclusions: The constructed resting state fMRI functional connectivity map points toward the possibility for fMRI resting state to estimate relative levels of activity in a metabolic map.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Neurology
Author, co-author :
Soddu, Andrea  ;  Université de Liège > Centre de recherches du cyclotron
Gomez, Francisco 
Heine, Lizette ;  Université de Liège > Centre de recherches du cyclotron
Di Perri, Carol ;  Université de Liège > Centre de recherches du cyclotron
Bahri, Mohamed Ali  ;  Université de Liège > Centre de recherches du cyclotron
Voss, Henning U.
Bruno, Marie-Aurélie ;  Université de Liège > Centre de recherches du cyclotron
VANHAUDENHUYSE, Audrey  ;  Centre Hospitalier Universitaire de Liège - CHU > Algologie - soins palliatifs
Phillips, Christophe  ;  Université de Liège > Centre de recherches du cyclotron
Demertzi, Athina  ;  Université de Liège > Centre de recherches du cyclotron
Chatelle, Camille ;  Université de Liège > Centre de recherches du cyclotron
Schrouff, Jessica ;  Université de Liège > Centre de recherches du cyclotron
Thibaut, Aurore ;  Université de Liège > Centre de recherches du cyclotron
Charland-Verville, Vanessa ;  Université de Liège > Centre de recherches du cyclotron
Noirhomme, Quentin ;  Université de Liège > Centre de recherches du cyclotron
Salmon, Eric  ;  Université de Liège > Centre de recherches du cyclotron
TSHIBANDA, Luaba ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Schiff, Nicolas D.
LAUREYS, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
More authors (9 more) Less
 These authors have contributed equally to this work.
Language :
English
Title :
Correlation between resting state fMRI total neuronal activity and PET metabolism in healthy controls and patients with disorders of consciousness
Publication date :
2016
Journal title :
Brain and Behavior
eISSN :
2162-3279
Publisher :
Wiley
Volume :
6
Issue :
1
Pages :
1-15
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
the Belgian National Funds for Scientific Research (FNRS)
Available on ORBi :
since 08 February 2016

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