magnetic resonance imaging; functional; minimally conscious state; persistent vegetative state; rehabilitation; neuroimaging; disorders of consciousness
Abstract :
[en] Objective: To describe the theoretic framework, design, and potential clinical applications of functional neuroimaging protocols in patients with disorders of consciousness. Data Sources: Recent published literature and authors' own work. Study Selection: Studies using functional neuroimaging techniques to investigate cognitive processing in patients diagnosed with vegetative and minimally conscious state. Data Extraction: Not applicable. Data Synthesis: Positron-emission tomography activation studies suggest that the vegetative state represents a global disconnection syndrome in which higher order association cortices are functionally disconnected from primary cortical areas. In contrast, patterns of activation in functional magnetic resonance imaging studies of patients in the minimally conscious state show preservation of large-scale cortical networks associated with language and visual processing. Conclusions: Novel applications of functional neuroimaging in patients with disorders of consciousness may aid in differential diagnosis, prognostic assessment and identication of pathophysiologic mechanisms. Improvements in patient characterization may, in turn, provide new opportunities for restoration of function through interventional neuromodulation.
Disciplines :
Orthopedics, rehabilitation & sports medicine
Author, co-author :
Giacino, Joseph T.
Hirsch, Joy
Schiff, Nicholas D.
Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Functional neuroimaging applications for assessment and rehabilitation planning in patients with disorders of consciousness
Publication date :
December 2006
Journal title :
Archives of Physical Medicine and Rehabilitation
ISSN :
0003-9993
eISSN :
1532-821X
Publisher :
W B Saunders Co-Elsevier Inc, Philadelphia, United States - Pennsylvania
Levy D.E., Sidtis J.J., Rottenberg D.A., et al. Differences in cerebral blood flow and glucose utilization in vegetative versus locked-in patients. Ann Neurol 22 (1987) 673-682
Laureys S., Goldman S., Phillips C., et al. Impaired effective cortical connectivity in vegetative state: preliminary investigation using PET. Neuroimage 9 (1999) 377-382
Schiff N.D., Ribary U., Moreno D.R., et al. Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain. Brain 125 (2002) 1210-1234
DeVolder A.G., Goffinet A.M., Bol A., Michel C., de Barsy T., and Laterre C. Brain glucose metabolism in postanoxic syndrome: positron emission tomographic study. Arch Neurol 47 (1990) 197-204
Tommasino C., Grana C., Lucignani G., Torri G., and Fazio F. Regional cerebral metabolism of glucose in comatose and vegetative state patients. J Neurosurg Anesthesiol 7 (1995) 109-116
Rudolf J., Ghaemi M., Haupt W.F., Szelies B., and Heiss W.D. Cerebral glucose metabolism in acute and persistent vegetative state. J Neurosurg Anesthesiol 11 (1999) 17-24
Rudolf J., Sobesky J., Grond M., and Heiss W.D. Identification by positron emission tomography of neuronal loss in acute vegetative state. Lancet 355 (2000) 115-116
Maquet P., Degueldre C., Delfiore G., et al. Functional neuroanatomy of human slow wave sleep. J Neurosci 17 (1997) 2807-2812
Buchsbaum M.S., Gillin J.C., Wu J., et al. Regional cerebral glucose metabolic rate in human sleep assessed by positron emission tomography. Life Sci 45 (1989) 1349-1356
Alkire M.T., Pomfrett C.J., Haier R.J., et al. Functional brain imaging during anesthesia in humans: effects of halothane on global and regional cerebral glucose metabolism. Anesthesiology 90 (1999) 701-709
Alkire M.T., Haier R.J., Shah N.K., and Anderson C.T. Positron emission tomography study of regional cerebral metabolism in humans during isoflurane anesthesia. Anesthesiology 86 (1997) 549-557
Alkire M.T., Haier R.J., Barker S.J., Shah N.K., Wu J.C., and Kao Y.J. Cerebral metabolism during propofol anesthesia in humans studied with positron emission tomography. Anesthesiology 82 (1995) 393-403
Laureys S., Lemaire C., Maquet P., Phillips C., and Franck G. Cerebral metabolism during vegetative state and after recovery to consciousness. J Neurol Neurosurg Psychiatry 67 (1999) 121
Laureys S., Faymonville M.E., Moonen G., Luxen A., and Maquet P. PET scanning and neuronal loss in acute vegetative state. Lancet 355 (2000) 1825-1826
Baars B., Ramsoy T., and Laureys S. Brain, conscious experience and the observing self. Trends Neurosci 26 (2003) 671-675
Salek-Haddadi A., Lemieux L., Merschhemke M., Friston K.J., Duncan J.S., and Fish D.R. Functional magnetic resonance imaging of human absence seizures. Ann Neurol 53 (2003) 663-667
Aghakhani Y., Bagshaw A.P., Benar C.G., et al. fMRI activation during spike and wave discharges in idiopathic generalized epilepsy. Brain 127 Pt 5 (2004) 1127-1144
Chang D.J., Zubal I.G., Gottschalk C., et al. Comparison of statistical parametric mapping and SPECT difference imaging in patients with temporal lobe epilepsy. Epilepsia 43 (2002) 68-74
Blumenfeld H., McNally K.A., Vanderhill S.D., et al. Positive and negative network correlations in temporal lobe epilepsy. Cereb Cortex 14 (2004) 892-902
Bassetti C., Vella S., Donati F., Wielepp P., and Weder B. SPECT during sleepwalking. Lancet 356 (2000) 484-485
Laureys S., Faymonville M.E., Goldman S., et al. Impaired cerebral connectivity in vegetative state. In: Gjedde A., Hansen S.B., Knudsen G.M., and Paulson O.B. (Eds). Physiological imaging of the brain with PET (2000), Academic Pr, San Diego 329-334
Laureys S., Faymonville M., Ferring M., et al. Differences in brain metabolism between patients in coma, vegetative state, minimally conscious state and locked-in syndrome [abstract]. Eur J Neurol 10 Suppl 1 (2003) 224
Gusnard D.A., and Raichle M.E. Searching for a baseline: functional imaging and the resting human brain. Nat Rev Neurosci 2 (2001) 685-694
Fiset P., Paus T., Daloze T., et al. Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study. J Neurosci 19 (1999) 5506-5513
Kaisti K.K., Langsjo J.W., Aalto S., et al. Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 99 (2003) 603-613
Minoshima S., Giordani B., Berent S., Frey K.A., Foster N.L., and Kuhl D.E. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 42 (1997) 85-94
Salmon E., Collette F., Degueldre C., Lemaire C., and Franck G. Voxel-based analysis of confounding effects of age and dementia severity on cerebral metabolism in Alzheimer's disease. Hum Brain Mapp 10 (2000) 39-48
Aupee A.M., Desgranges B., Eustache F., et al. Voxel-based mapping of brain hypometabolism in permanent amnesia with PET. Neuroimage 13 (2001) 1164-1173
Vogt B.A., Vogt L., and Laureys S. Cytology and functionally correlated circuits of human posterior cingulate areas. Neuroimage 29 (2006) 452-466
Laureys S., Faymonville M.E., Luxen A., Lamy M., Franck G., and Maquet P. Restoration of thalamocortical connectivity after recovery from persistent vegetative state. Lancet 355 (2000) 1790-1791
Dalle O.G., Gerstenbrand F., Lucking C.F., Peters G., and Peters U.H. The apallic syndrome (1977), Springer-Verlag, Berlin
Menon D.K., Owen A.M., Williams E.J., et al. Cortical processing in persistent vegetative state. Lancet 352 (1998) 200
Laureys S., Faymonville M.E., Del Fiore G., et al. Brain activation during somatosensory and auditory stimulation in acute vegetative state of anoxic origin. In: Gjedde A., Hansen S.B., Knudsen G.M., and Paulson O.B. (Eds). Physiological imaging of the brain with PET (2000), Academic Pr, San Diego 319-327
Laureys S., Faymonville M.E., Degueldre C., et al. Auditory processing in the vegetative state. Brain 123 (2000) 1589-1601
McQuillen M.P. Can people who are unconscious or in the "vegetative state" perceive pain?. Issues Law Med 6 (1991) 373-383
Klein M. Perception of pain in the persistent vegetative state?. Eur J Pain 1 (1997) 165-167 discussion 167-8
Laureys S., Faymonville M.E., Peigneux P., et al. Cortical processing of noxious somatosensory stimuli in the persistent vegetative state. Neuroimage 17 (2002) 732-741
Bushnell M.C., Duncan G.H., Hofbauer R.K., Ha B., Chen J., and Carrier B. Pain perception: is there a role for primary somatosensory cortex?. Proc Natl Acad Sci U S A 96 (1999) 7705-7709
Treede R.D., Kenshalo D.R., Gracely R.H., and Jones A.K. The cortical representation of pain. Pain 79 (1999) 105-111
Laureys S., Perrin F., Faymonville M.E., et al. Cerebral processing in the minimally conscious state. Neurology 63 (2004) 916-918
Bekinschtein T., Niklison J., Sigman L., et al. Emotion processing in the minimally conscious state [published erratum in: J Neural Neurosurg Psychiatry 2004;75:1086]. J Neurol Neurosurg Psychiatry 75 (2004) 788
Giacino J., and Whyte J. The vegetative and minimally conscious states: current knowledge and remaining questions. J Head Trauma Rehabil 20 (2005) 30-50
Price C.J., Moore C.J., and Friston K.J. Subtractions, conjunctions, and interactions in experimental design of activation studies. Hum Brain Mapp 5 (1997) 264-272
Hirsch J., Rodriguez-Moreno D., and Kim K.H. Interconnected large-scale systems for three fundamental cognitive tasks revealed by functional MRI. J Cogn Neurosci 13 (2001) 1-16
Souweidane M.M., Kim K.H., McDowall R., et al. Brain mapping in sedated infants and young children with passive-functional magnetic resonance imaging. Pediatr Neurosurg 30 (1999) 86-91
Hirsch J., Ruge M.I., Kim K.H., et al. An Integrated fMRI procedure for preoperative mapping of cortical areas associated with tactile, motor, language, and visual functions. Neurosurgery 47 (2000) 711-722
Hirsch J., DeLaPaz R.L., Relkin N.R., et al. Illusory contours activate specific regions in human visual cortex: evidence from functional magnetic resonance imaging. Proc Natl Acad Sci U S A 92 (1995) 6469-6473
Ruge M.I., Victor J., Hosain S., et al. Concordance between functional magnetic resonance imaging and intraoperative language mapping. Stereotactic Funct Neurosurg 72 (1999) 95-102
Schiff N.D., Rodriguez-Moreno D., Kamal A., et al. Functional MRI reveals large scale network activation in minimally conscious patients. Neurology 64 (2005) 514-523
Giacino J., Ashwal S., Childs N., et al. The minimally conscious state: definition and diagnostic criteria. Neurology 58 (2002) 349-353
Binder J.R., Frost J.A., Hammeke T.A., et al. Human temporal lobe activation by speech and non-speech sounds. Cereb Cortex 10 (2000) 512-518
Cuenod C.A., Bookheimer S.Y., Hertz-Pannier L., Zeffiro T.A., Theodore W.H., and LeBihan D. Functional MRI during word generation, using conventional equipment: A potential tool for language localization in the clinical environment. Neurology 45 (1995) 1821-1827
Crinion J.T., Lambon-Ralph M.A., Warburton E.A., Howard D., and Wise R.J.S. Temporal lobe regions engaged during normal speech comprehension. Brain 126 Pt 5 (2003) 1193-1201
Epstein R., and Kanwisher N. A cortical representation of the local visual environment. Nature 392 (1999) 598-601
Kanwisher N., McDermott J., and Chun M.M. The fusiform face area: a module in human extrastriate cortex specialized for face perception. J Neurosci 17 (1997) 4302-4311
Kanwisher N. Domain specificity in face perception. Nat Neurosci 3 (2000) 759-763
Passler M.A., and Riggs R.V. Positive outcomes in traumatic brain injury-vegetative state: patients treated with bromocriptine. Arch Phys Med Rehabil 82 (2001) 311-315
Meythaler J.M., Brunner R.C., Johnson A., and Novack T.A. Amantadine to improve neurorecovery in traumatic brain injury-associated diffuse axonal injury: a pilot double-blind randomized trial. J Head Trauma Rehabil 17 (2002) 300-313
Nguyen D.K., and Botez M.I. Diaschisis and neurobehavior. Can J Neurol Sci 25 (1998) 5-12
Gold L., and Lauritzen M. Neuronal deactivation explains decreased cerebellar blood flow in response to focal cerebral ischemia or suppressed neocortical function. Proc Natl Acad Sci U S A 99 (2002) 7699-7704
Timofeev I., Grenier F., and Steriade M. Disfacilitation and active inhibition in the neocortex during the natural sleep-wake cycle: an intracellular study. Proc Natl Acad Sci U S A 98 (2001) 1924-1929
Steriade M. Neocortical cell classes are flexible entities. Nat Rev Neurosci 5 (2004) 121-134
Szelies B., Herholz K., Pawlik G., Karbe H., Hebold I., and Heiss W.D. Widespread functional effects of discrete thalamic infarction. Arch Neurol 48 (1991) 178-182
Caselli R.J., Graff-Radford N.R., and Rezai K. Thalamocortical diaschisis: single-photon emission tomographic study of cortical blood flow changes after focal thalamic infarction. Neuropsychiatr Neuropsychol Behav Neurol 4 (1991) 193-214
Kobylarz E.J., and Schiff N.D. Neurophysiological correlates of persistent vegetative and minimally conscious states. Neuropsychol Rehabil 15 (2005) 323-332
Williams D., and Parsons-Smith G. Thalamic activity in stupor. Brain 74 (1951) 377-398
Burruss J.W., and Chacko R.C. Episodically remitting akinetic mutism following subarachnoid hemorrhage. J Neuropsychiatr Clin Neurosci 11 (1999) 100-102
Clauss R.P., van der Merwe C.E., and Nel H.W. Arousal from a semi-comatose state on zolpidem. S Afr Med J 91 (2001) 788-789
Cohen L., Chaaban B., and Habert M.O. Transient improvement of aphasia with zolpidem. N Engl J Med 350 (2004) 949-950
Santhakumar V., Ratzliff A.D., Jeng J., Toth Z., and Soltesz I. Long-term hyperexcitability in the hippocampus after experimental head trauma. Ann Neurol 50 (2001) 708-717
Leigh R.J., Foley J.M., Remler B.F., and Civil R.H. Oculogyric crisis: a syndrome of thought disorder and ocular deviation. Ann Neurol 22 (1987) 13-17
Berthier M.L., Kulisevsky J.J., Gironell A., and Lopez O.L. Obsessive compulsive disorder and traumatic brain injury: behavioral, cognitive, and neuroimaging findings. Neuropsychiatry Neuropsychol Behav Neurol 14 (2001) 23-31
Blackman J.A., Patrick P.D., Buck M.L., and Rust R.S. Paroxysmal autonomic instability with dystonia after brain injury. Arch Neurol 61 (2004) 321-328
Fleet W.S., Valenstein E., Watson R.T., and Heilman K.M. Dopamine agonist therapy for neglect in humans. Neurology 37 (1987) 1765-1770
Matsuda W., Matsumura A., Komatsu Y., Yanaka K., and Nose T. Awakenings from persistent vegetative state: report of three cases with parkinsonism and brain stem lesions on MRI. J Neurol Neurosurg Psychiatry 74 (2003) 1571-1573
Selden N.R., Gitelman D.R., Salamon-Murayama N., Parrish T.B., and Mesulam M.M. Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. Brain 121 (1998) 2249-2257
Llinas R.R., Ribary U., Jeanmonod D., Kronberg E., and Mitra P.P. Thalamocortical dysrhythmia: a neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proc Natl Acad Sci U S A 96 (1999) 15222-15227
Davey M.P., Victor J.D., and Schiff N.D. Power spectra and coherence in the EEG of a vegetative patient with severe asymmetric brain damage. Clin Neurophysiol 111 (2000) 1949-1954
McDowell S., Whyte J., and D'Esposito M. Differential effect of a dopaminergic agonist on prefrontal function in traumatic brain injury patients. Brain 121 (1998) 1155-1164
Meythaler J.M., Brunner R.C., Johnson A., and Novack T.A. Amantadine to improve neurorecovery in traumatic brain injury-associated diffuse axonal injury: a pilot double-blind randomized trial. J Head Trauma Rehabil 17 (2002) 300-313
Whyte J., Katz D., Long D., et al. Predictors of outcome in prolonged posttraumatic disorders of consciousness and assessment of medication effects: a multicenter study. Arch Phys Med Rehabil 86 (2005) 453-462
Schiff N.D., Rezai A.R., and Plum F.P. A neuromodulation strategy for rational therapy of complex brain injury states. Neurol Res 22 (2000) 267-272
The Multi-Society Task Force on PVS. Medical aspects of the persistent vegetative state (2). N Engl J Med 330 (1994) 1572-1579
Fins J.J. Constructing an ethical stereotaxy for severe brain injury: balancing risks, benefits and access. Nat Rev Neurosci 4 (2003) 323-327
Hirsch J. Raising consciousness. J Clin Investig 115 (2005) 1102-1103
Fins J.J. Rethinking disorders of consciousness: new research and its implications. Hastings Cent Rep 35 2 (2005) 22-24
