Article (Scientific journals)
Can We Cluster ICU Treatment Strategies for Traumatic Brain Injury by Hospital Treatment Preferences?
Ceyisakar, Iris E; Huijben, Jilske A; Maas, Andrew I R et al.
2022In Neurocritical Care
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Keywords :
Between-hospital variation; Comparative effectiveness research; Provider profiling; Traumatic brain injury
Abstract :
[en] BACKGROUND: In traumatic brain injury (TBI), large between-center differences in treatment and outcome for patients managed in the intensive care unit (ICU) have been shown. The aim of this study is to explore if European neurotrauma centers can be clustered, based on their treatment preference in different domains of TBI care in the ICU. METHODS: Provider profiles of centers participating in the Collaborative European Neurotrauma Effectiveness Research in TBI study were used to assess correlations within and between the predefined domains: intracranial pressure monitoring, coagulation and transfusion, surgery, prophylactic antibiotics, and more general ICU treatment policies. Hierarchical clustering using Ward's minimum variance method was applied to group data with the highest similarity. Heat maps were used to visualize whether hospitals could be grouped to uncover types of hospitals adhering to certain treatment strategies. RESULTS: Provider profiles were available from 66 centers in 20 different countries in Europe and Israel. Correlations within most of the predefined domains varied from low to high correlations (mean correlation coefficients 0.2-0.7). Correlations between domains were lower, with mean correlation coefficients of 0.2. Cluster analysis showed that policies could be grouped, but hospitals could not be grouped based on their preference. CONCLUSIONS: Although correlations between treatment policies within domains were found, the failure to cluster hospitals indicates that a specific treatment choice within a domain is not a proxy for other treatment choices within or outside the domain. These results imply that studying the effects of specific TBI interventions on outcome can be based on between-center variation without being substantially confounded by other treatments. TRIAL REGISTRATION: We do not report the results of a health care intervention.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Ceyisakar, Iris E ;  Center for Medical Decision Making, Department of Public Health, Erasmus Medical  ; Department of Neurosurgery, Antwerp University Hospital, University of Antwerp, Drie
Huijben, Jilske A;  Center for Medical Decision Making, Department of Public Health, Erasmus Medical
Maas, Andrew I R;  Department of Neurosurgery, Antwerp University Hospital, University of Antwerp, Drie
Lingsma, Hester F;  Center for Medical Decision Making, Department of Public Health, Erasmus Medical
van Leeuwen, Nikki;  Center for Medical Decision Making, Department of Public Health, Erasmus Medical
CENTER-TBI participants and, investigators
Other collaborator :
Åkerlund, Cecilia
Amrein, Krisztina
Andelic, Nada
Andreassen, Lasse
Anke, Audny
Antoni, Anna
Audibert, Gérard
Azouvi, Philippe
Azzolini, Maria Luisa
Bartels, Ronald
Barzó, Pál
Beauvais, Romuald
Beer, Ronny
Bellander, Bo-Michael
Belli, Antonio
Benali, Habib
Berardino, Maurizio
Beretta, Luigi
Blaabjerg, Morten
Bragge, Peter
Brazinova, Alexandra
Brinck, Vibeke
Brooker, Joanne
Brorsson, Camilla
Buki, Andras
Bullinger, Monika
Cabeleira, Manuel
Caccioppola, Alessio
Calappi, Emiliana
Calvi, Maria Rosa
Cameron, Peter
Lozano, Guillermo Carbayo
Carbonara, Marco
Cavallo, Simona
Chevallard, Giorgio
Chieregato, Arturo
Citerio, Giuseppe
Clusmann, Hans
Coburn, Mark
Coles, Jonathan
Cooper, Jamie D
Correia, Marta
Čović, Amra
Curry, Nicola
Czeiter, Endre
Czosnyka, Marek
Dahyot-Fizelier, Claire
Dark, Paul
Dawes, Helen
De Keyser, Véronique ;  Université de Liège - ULiège > Département de Psychologie
Degos, Vincent
Corte, Francesco Della
Boogert, Hugo den
Depreitere, Bart
Đilvesi, Đula
Dixit, Abhishek
Donoghue, Emma
Dreier, Jens
Dulière, Guy-Loup
Ercole, Ari
Esser, Patrick
Ezer, Erzsébet
Fabricius, Martin
Feigin, Valery L
Foks, Kelly
Frisvold, Shirin
Furmanov, Alex
Gagliardo, Pablo
Galanaud, Damien
Gantner, Dashiell
Gao, Guoyi
George, Pradeep
GHUYSEN, Alexandre ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des urgences
Giga, Lelde
Glocker, Ben
Golubovic, Jagoš
Gomez, Pedro A
Gratz, Johannes
Gravesteijn, Benjamin
Grossi, Francesca
Gruen, Russell L
Gupta, Deepak
Haagsma, Juanita A
Haitsma, Iain
Helbok, Raimund
Helseth, Eirik
Horton, Lindsay
Huijben, Jilske
Hutchinson, Peter J
Jacobs, Bram
Jankowski, Stefan
Jarrett, Mike
Jiang, Ji-Yao
Johnson, Faye
Jones, Kelly
Karan, Mladen
Kolias, Angelos G
Kompanje, Erwin
Kondziella, Daniel
Kornaropoulos, Evgenios
Koskinen, Lars-Owe
Kovács, Noémi
Kowark, Ana
Lagares, Alfonso
Lanyon, Linda
LAUREYS, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > > Centre du Cerveau²
Lecky, Fiona
LEDOUX, Didier  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Lefering, Rolf
Legrand, Valerie
Lejeune, Aurelie
Levi, Leon
Lightfoot, Roger
Lingsma, Hester
Maas, Andrew I R
Castaño-León, Ana M
Maegele, Marc
Majdan, Marek
Manara, Alex
Manley, Geoffrey
Martino, Costanza
Maréchal, Hugues
Mattern, Julia
McMahon, Catherine
Melegh, Béla
Menon, David
Menovsky, Tomas
Mikolic, Ana
Misset, Benoît ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Muraleedharan, Visakh
Murray, Lynnette
Negru, Ancuta
Nelson, David
Newcombe, Virginia
Nieboer, Daan
Nyirádi, József
Olubukola, Otesile
Oresic, Matej
Ortolano, Fabrizio
Palotie, Aarno
Parizel, Paul M
Payen, Jean-François
Perera, Natascha
Perlbarg, Vincent
Persona, Paolo
Peul, Wilco
Piippo-Karjalainen, Anna
Pirinen, Matti
Pisica, Dana
Ples, Horia
Polinder, Suzanne
Pomposo, Inigo
Posti, Jussi P
Puybasset, Louis
Radoi, Andreea
Ragauskas, Arminas
Raj, Rahul
Rambadagalla, Malinka
Helmrich, Isabel Retel
Rhodes, Jonathan
Richardson, Sylvia
Richter, Sophie
Ripatti, Samuli
Rocka, Saulius
Roe, Cecilie
Roise, Olav
Rosand, Jonathan
Rosenfeld, Jeffrey V
Rosenlund, Christina
Rosenthal, Guy
Rossaint, Rolf
Rossi, Sandra
Rueckert, Daniel
Rusnák, Martin
Sahuquillo, Juan
Sakowitz, Oliver
Sanchez-Porras, Renan
Sandor, Janos
Schäfer, Nadine
Schmidt, Silke
Schoechl, Herbert
Schoonman, Guus
Schou, Rico Frederik
Schwendenwein, Elisabeth
Sewalt, Charlie
Singh, Ranjit D
Skandsen, Toril
Smielewski, Peter
Sorinola, Abayomi
Stamatakis, Emmanuel
Stanworth, Simon
Stevens, Robert
Stewart, William
Steyerberg, Ewout W
Stocchetti, Nino
Sundström, Nina
Takala, Riikka
Tamás, Viktória
Tamosuitis, Tomas
Taylor, Mark Steven
Ao, Braden Te
Tenovuo, Olli
Theadom, Alice
Thomas, Matt
Tibboel, Dick
Timmers, Marjolein
Tolias, Christos
Trapani, Tony
Tudora, Cristina Maria
Unterberg, Andreas
Vajkoczy, Peter
Vallance, Shirley
Valeinis, Egils
Vámos, Zoltán
van der Jagt, Mathieu
Van der Steen, Gregory
van der Naalt, Joukje
van Dijck, Jeroen T J M
van Erp, Inge A
van Essen, Thomas A
Van Hecke, Wim
van Heugten, Caroline
Van Praag, Dominique
van Veen, Ernest
Vyvere, Thijs Vande
van Wijk, Roel P J
Vargiolu, Alessia
Vega, Emmanuel
Velt, Kimberley
Verheyden, Jan
Vespa, Paul M
Vik, Anne
Vilcinis, Rimantas
Volovici, Victor
von Steinbüchel, Nicole
Voormolen, Daphne
Vulekovic, Petar
Wang, Kevin K W
Whitehouse, Daniel
Wiegers, Eveline
Williams, Guy
Wilson, Lindsay
Winzeck, Stefan
Wolf, Stefan
Yang, Zhihui
Ylén, Peter
Younsi, Alexander
Zeiler, Frederick A
Zelinkova, Veronika
Ziverte, Agate
Zoerle, Tommaso
More authors (241 more) Less
Language :
English
Title :
Can We Cluster ICU Treatment Strategies for Traumatic Brain Injury by Hospital Treatment Preferences?
Publication date :
2022
Journal title :
Neurocritical Care
ISSN :
1541-6933
eISSN :
1556-0961
Publisher :
Humana Press, Us
Peer reviewed :
Peer Reviewed verified by ORBi
Funding number :
EC grant 602150/FP7 Ideas: European Research Council/
Commentary :
© 2021. The Author(s).
Available on ORBi :
since 27 March 2022

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