[en] Disorders of consciousness (DoC) are a heterogeneous spectrum of clinical conditions, including coma, unresponsive wakefulness syndrome, and minimally conscious state. DoC are clinically defined on the basis of behavioral cues expressed by the patients, on the assumption that such behavioral responses of the patient are representative of the patient's degree of consciousness impairment. However, many studies have highlighted the issues arising from formulating a DoC diagnosis merely on behavioral assessment. Overcoming the limitations of behavioral assessment, neuroimaging provides a direct window on the cerebral activity of the patient, bypassing the motor, perceptual, or cognitive deficits that might hamper the patient's ability to produce an appropriate behavioral response. This chapter provides an overview of available molecular, functional, and structural neuroimaging evidence in patients with DoC. This chapter introduces the neuroimaging tools available in the clinical settings of nuclear medicine and neuroradiology and presents the evidence on the role of neuroimaging tools to improve the clinical management of DoC patients, from the standpoint of differential diagnosis and prognosis. Last, we outline the open questions in the field, and point at actions that are urgently needed to fully exploit neuroimaging tools to advance scientific understanding and clinical management of DoC.
Disciplines :
Radiologie, médecine & imagerie nucléaire
Auteur, co-auteur :
Sala, Arianna ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Coma Science Group
Gosseries, Olivia ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Coma Science Group
Laureys, Steven ; Université de Liège - ULiège > Département des sciences cliniques
Annen, Jitka ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Coma Science Group
Langue du document :
Anglais
Titre :
Advances in neuroimaging in disorders of consciousness.
Date de publication/diffusion :
2025
Titre de l'ouvrage principal :
Handbook of Clinical Neurology: Coma, Stupor, and Related Disorders of Consciousness
Titre traduit de l'ouvrage principal :
[en] Coma, Stupor, and Related Disorders of Consciousness
We would like to express our gratitude to the University and University Hospital of Li\u00E8ge, the Belgian National Funds for Scientific Research (FRS-FNRS), in the framework of the research projects No PDR/BEJ T.0134.21 and MIS F.4521.23, ERA-Net FLAG-ERA JTC2021 project ModelDXConsciousness (Human Brain Project Partnering Project), the Horizon 2020 MSCA\u2014Research and Innovation Staff exchange (101131344\u2014DOCBOX), the European Space Agency (ESA) and the Belgian Federal Science Policy Office (BELSPO) in the framework of the PRODEX Programme, the BIAL Foundation, the Mind Science Foundation, the fund Generet of the King Baudouin Foundation, the Mind-Care foundation and AstraZeneca Foundation.S.L. is a research director, O.G. is a research associate, and A.S. is a postdoctoral research fellow at FRS-FNRS. J.A. is a postdoctoral fellow funded (1265522N) by the Fund for Scientific Research-Flanders (FWO).We would like to express our gratitude to the University and University Hospital of Li\u00E8ge, the Belgian National Funds for Scientific Research (FRS-FNRS), in the framework of the research projects No PDR/BEJ T.0134.21 and MIS F.4521.23, ERA-Net FLAG-ERA JTC2021 project ModelDXConsciousness (Human Brain Project Partnering Project), the Horizon 2020 MSCA\u2014Research and Innovation Staff exchange (101131344\u2014DOCBOX), the European Space Agency (ESA) and the Belgian Federal Science Policy Office (BELSPO) in the framework of the PRODEX Programme, the BIAL Foundation, the Mind Science Foundation, the fund Generet of the King Baudouin Foundation, the Mind-Care foundation and AstraZeneca Foundation. S.L. is a research director, O.G. is a research associate, and A.S. is a postdoctoral research fellow at FRS-FNRS. J.A. is a postdoctoral fellow funded (1265522N) by the Fund for Scientific Research-Flanders (FWO). The authors have no conflicts of interest to declare.
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