Multiple fMRI system-level baseline connectivity is disrupted in patients with consciousness alterations

[en] Introduction: In healthy conditions, group-level fMRI resting state analyses identify ten resting state networks (RSNs) of cognitive relevance. Here, we aim to assess the tennetwork model in severely brain-injured patients suffering from disorders of consciousness and to identify those networks which will be most relevant to discriminate between patients and healthy subjects. Methods: 300 fMRI volumes were obtained in 27 healthy controls and 53 patients in minimally conscious state (MCS), vegetative state/unresponsive wakefulness syndrome (VS/ UWS) and coma. Independent component analysis (ICA) reduced data dimensionality. The ten networks were identified by means of a multiple template-matching procedure and were tested on neuronality properties (neuronal vs non-neuronal) in a data-driven way. Univariate analyses detected between-group differences in networks’ neuronal properties and estimated voxel-wise functional connectivity in the networks, which were significantly less identifiable in patients. A nearest-neighbor “clinical” classifier was used to determine the networks with high between-group discriminative accuracy. Results: Healthy controls were characterized by more neuronal components compared to patients in VS/UWS and in coma. Compared to healthy controls, fewer patients in MCS and VS/UWS showed components of neuronal origin for the left executive control network, default mode network (DMN), auditory, and right executive control network. The “clinical” classifier indicated the DMN and auditory network with the highest accuracy (85.3%) in discriminating patients from healthy subjects.

Disciplines :

Neurosciences & behavior

Author, co-author :

Demertzi, Athina ^✱; Université de Liège - ULiège > Centre de recherches du cyclotron

Gomez, Francisco ^✱

Crone, Julia-Sophia

Vanhaudenhuyse, Audrey ; Université de Liège - ULiège > Centre de recherches du cyclotron

TSHIBANDA, Luaba ; Centre Hospitalier Universitaire de Liège - CHU > Radiodiagnostic

Noirhomme, Quentin ; Université de Liège - ULiège > Centre de recherches du cyclotron

Thonnard, Marie ; Université de Liège - ULiège > Centre de recherches du cyclotron

Charland-Verville, Vanessa ; Université de Liège - ULiège > Centre de recherches du cyclotron

KIRSCH, Murielle ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation

LAUREYS, Steven ^✱; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman

Soddu, Andrea ^✱

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Multiple fMRI system-level baseline connectivity is disrupted in patients with consciousness alterations

Publication date :

2014

Journal title :

Cortex: A Journal Devoted to the Study of the Nervous System and Behavior

ISSN :

0010-9452

eISSN :

1973-8102

Publisher :

Masson, Milano, Italy

Volume :

Pages :

35-46

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 01 March 2014

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735 (13 by ULiège)

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Scopus citations^®

165

Scopus citations^®
without self-citations

116

OpenCitations

141

OpenAlex citations

189

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