Article (Scientific journals)
Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness
Perl, Yonatan Sanz; Pallavicini, Carla; Ipiña, Ignacio Perez et al.
2021In PLoS Computational Biology
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Abstract :
[en] Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness.
Research center :
CHU de Liège-Centre du Cerveau² - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Perl, Yonatan Sanz;  University of Buenos Aires > Department of Physics
Pallavicini, Carla;  University of Buenos Aires > Department of Physics
Ipiña, Ignacio Perez;  University of Buenos Aires > Department of Physics
Demertzi, Athina  ;  Université de Liège - ULiège > GIGA Consciousness - Physiology of Cognition
BONHOMME, Vincent  ;  Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation
Martial, Charlotte  ;  Université de Liège - ULiège > GIGA Consciousness - Coma Science Group
Panda, Rajanikant  ;  Université de Liège - ULiège > GIGA Consciousness - Coma Science Group
Annen, Jitka  ;  Université de Liège - ULiège > GIGA Consciousness - Coma Science Group ; CHU Liège - Central University Hospital of Liege > Centre du Cerveau²
Ibañez, Agustin;  University of Buenos Aires
Kringelbach, Morten;  University of Oxford > Department of Psychiatry
Deco, Gustavo;  Universitat Pompeu Fabra
Laufs, Helmut;  Goethe University > Department of Neurology and Brain Imaging Center
Sitt, Jacobo;  Institut du Cerveau et de la Moelle epinière
Laureys, Steven  ;  Université de Liège - ULiège > GIGA Consciousness - Coma Science Group
Tagliazucchi, Enzo;  University of Buenos Aires > Department of Physics
More authors (5 more) Less
Language :
English
Title :
Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness
Publication date :
27 July 2021
Journal title :
PLoS Computational Biology
ISSN :
1553-734X
eISSN :
1553-7358
Publisher :
Public Library of Science, United States - California
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 January 2022

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