Article (Scientific journals)
Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis
Faymonville, Marie-Elisabeth; Roediger, Laurence; Del Fiore, Guy et al.
2003In Cognitive Brain Research, 17 (2), p. 255-262
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Keywords :
Hypnotic state; Pain; Psychophysiological interaction analysis; Positron emission tomography; Regional cerebral blood flow
Abstract :
[en] The neural mechanisms underlying the antinociceptive effects of hypnosis are not well understood. Using positron emission tomography (PET), we recently showed that the activity in the anterior cingulate cortex (midcingulate area 24a') covaries with the hypnosis-induced reduction of affective and sensory responses to noxious thermal stimulation [Faymonville et al., Anesthesiology 92 (2000) 1257-1267]. In the present study, we assessed changes in cerebral functional connectivity related to the hypnotic state, compared to simple distraction and the resting state. Nineteen highly hypnotizable right-handed volunteers were studied using (H2O)-O-15-PET. The experimental conditions were hot noxious or warm non-noxious stimulation of the right hand during resting state, mental imagery and hypnotic state. Using a psychophysiological interaction analysis, we identified brain areas that would respond to noxious stimulations under the modulatory action of the midcingulate cortex in, and only in, the hypnotic state. Hypnosis, compared to the resting state, reduced pain perception by 50%. Pain perception during rest and mental imagery was not significantly different. Analysis of PET data showed that the hypnotic state, compared to normal alertness (i.e., rest and mental imagery), significantly enhanced the functional modulation between midcingulate cortex and a large neural network encompassing bilateral insula, pregenual anterior cingulate cortex, pre-supplementary motor area, right prefrontal cortex and striatum, thalamus and brainstem. These findings point to a critical role for the midcingulate cortex in the modulation of a large cortical and subcortical network underlying its influence on sensory, affective, Cognitive and behavioral aspects of nociception, in the specific context of hypnosis. (C) 2003 Elsevier B.V. All rights reserved.
Disciplines :
Neurosciences & behavior
Author, co-author :
Faymonville, Marie-Elisabeth ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Roediger, Laurence ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Del Fiore, Guy
Delgueldre, Christian
Phillips, Christophe  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Lamy, Maurice ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
Title :
Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis
Publication date :
July 2003
Journal title :
Cognitive Brain Research
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
Issue :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 November 2008


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