Article (Scientific journals)
Modulation of the spontaneous hemodynamic response function across levels of consciousness
Wu, Guo-Rong; Di Perri, Carol; CHARLAND-VERVILLE, Vanessa et al.
2019In NeuroImage
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Abstract :
[en] Functional imaging research has already contributed with several results to the study of neural correlates of consciousness. Apart from task-related activation derived in fMRI, PET based glucose metabolism rate or cerebral blood flow account for a considerable proportion of the study of brain activity under different levels of consciousness. Resting state functional connectivity MRI is playing a crucial role to explore the consciousness related functional integration, successfully complementing PET, another widely used neuroimaging technique. Here, spontaneous hemodynamic response is introduced to characterize resting state brain activity giving information on the local metabolism (neurovascular coupling), and useful to improve the time-resolved activity and connectivity measures based on BOLD fMRI. This voxel-wise measure is then used to investigate the loss of consciousness under Propofol anesthesia and unresponsive wakefulness syndrome. Changes in the hemodynamic response in precuneus and posterior cingulate are found to be a common principle underlying loss of consciousness in both conditions. The thalamus appears to be less obviously modulated by Propofol, compared with frontoparietal regions. However, a significant increase in spontaneous thalamic hemodynamic response was found in patients in unresponsive wakefulness syndrome compared with healthy control. Our results ultimately show that anesthesia- or pathology-induced neurovascular coupling could be tracked by modulated spontaneous hemodynamic response derived from resting state fMRI.
Disciplines :
Neurosciences & behavior
Author, co-author :
Wu, Guo-Rong
Di Perri, Carol ;  Université de Liège - ULiège > Consciousness-Coma Science Group
CHARLAND-VERVILLE, Vanessa ;  Centre Hospitalier Universitaire de Liège - CHU > Services opérationnels de l'Administrateur Délégué > Unité de psychologie de la santé
Martial, Charlotte  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Carrière, Manon ;  Université de Liège - ULiège > Consciousness-Coma Science Group
VANHAUDENHUYSE, Audrey  ;  Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Centre interdisciplinaire d'algologie
LAUREYS, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Centre intégré pluridisc. étude cerveau-cognition-conscience
Marinazzo, Daniele
Language :
English
Title :
Modulation of the spontaneous hemodynamic response function across levels of consciousness
Publication date :
2019
Journal title :
NeuroImage
ISSN :
1053-8119
eISSN :
1095-9572
Publisher :
Elsevier, United States - Florida
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 July 2019

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