Modulation of the spontaneous hemodynamic response function across levels of consciousness

[en] Functional imaging research has already contributed with several results to the study of neural correlates of consciousness. Apart from task-related activation derived in fMRI, PET based glucose metabolism rate or cerebral blood flow account for a considerable proportion of the study of brain activity under different levels of consciousness. Resting state functional connectivity MRI is playing a crucial role to explore the consciousness related functional integration, successfully complementing PET, another widely used neuroimaging technique. Here, spontaneous hemodynamic response is introduced to characterize resting state brain activity giving information on the local metabolism (neurovascular coupling), and useful to improve the time-resolved activity and connectivity measures based on BOLD fMRI. This voxel-wise measure is then used to investigate the loss of consciousness under Propofol anesthesia and unresponsive wakefulness syndrome. Changes in the hemodynamic response in precuneus and posterior cingulate are found to be a common principle underlying loss of consciousness in both conditions. The thalamus appears to be less obviously modulated by Propofol, compared with frontoparietal regions. However, a significant increase in spontaneous thalamic hemodynamic response was found in patients in unresponsive wakefulness syndrome compared with healthy control. Our results ultimately show that anesthesia- or pathology-induced neurovascular coupling could be tracked by modulated spontaneous hemodynamic response derived from resting state fMRI.

Disciplines :

Neurosciences & behavior

Author, co-author :

Wu, Guo-Rong

Di Perri, Carol ; Université de Liège - ULiège > Consciousness-Coma Science Group

CHARLAND-VERVILLE, Vanessa ; Centre Hospitalier Universitaire de Liège - CHU > Services opérationnels de l'Administrateur Délégué > Unité de psychologie de la santé

Martial, Charlotte ; Université de Liège - ULiège > Consciousness-Coma Science Group

Carrière, Manon ; Université de Liège - ULiège > Consciousness-Coma Science Group

VANHAUDENHUYSE, Audrey ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Centre interdisciplinaire d'algologie

LAUREYS, Steven ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Centre intégré pluridisc. étude cerveau-cognition-conscience

Marinazzo, Daniele

Language :

English

Title :

Modulation of the spontaneous hemodynamic response function across levels of consciousness

Publication date :

2019

Journal title :

NeuroImage

ISSN :

1053-8119

eISSN :

1095-9572

Publisher :

Elsevier, United States - Florida

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 July 2019

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