[en] We review cerebral processing of auditory and noxious stimuli in minimally conscious state (MCS) and vegetative state (VS) patients. In contrast with limited brain activation found in VS patients, MCS patients show activation similar to controls in response to auditory, emotional and noxious stimuli. Despite an apparent clinical similarity between MCS and VS patients, functional imaging data show striking differences in cortical segregation and integration between these two conditions. However, in the absence of a generally accepted neural correlate of consciousness as measured by functional neuroirnaging, clinical assessment remains the gold standard for the evaluation and management of severely brain damaged patients.
Disciplines :
Neurology Neurosciences & behavior
Author, co-author :
Boly, Mélanie ; Université de Liège - ULiège > Neurologie
Faymonville, Marie-Elisabeth ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Peigneux, Philippe ; Université de Liège - ULiège > Centre de recherches du cyclotron
Lambermont, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Damas, François ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Lamy, Maurice ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Moonen, Gustave ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine
Maquet, Pierre ; Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Cerebral processing of auditory and noxious stimuli in severely brain injured patients: Differences between VS and MCS
Persistent vegetative state: Report of the American Neurological Association Committee on Ethical Affairs (1993) Annals of Neurology, 33, pp. 386-390
Andrews, K., Murphy, L., Munday, R., Littlewood, C., Misdiagnosis of the vegetative state: Retrospective study in a rehabilitation unit (1996) British Medical Journal, 313, pp. 13-16
Baars, B.J., Ramsoy, T.Z., Laureys, S., Brain, conscious experience and the observing self (2003) Trends in Neuroscience, 26, pp. 671-675
Bekinschtein, T., Leiguarda, R., Armony, J., Owen, A., Carpintiero, S., Niklison, J., Emotion processing in the minimally conscious state (2004) Journal of Neurology, Neuro-surgery, and Psychiatry, 75, p. 788
Boly, M., Faymonville, M.E., Peigneux, P., Lambermont, B., Damas, P., Del Fiore, G., Auditory processing in severely brain injured patients: Differences between the minimally conscious state and the persistent vegetative state (2004) Archives of Neurology, 61, pp. 233-238
Childs, N.L., Mercer, W.N., Childs, H.W., Accuracy of diagnosis of persistent vegetative state (1993) Neurology, 43, pp. 1465-1467
Friston, K.J., Analysing brain images: Principles and overview (1997) Human Brain Function, pp. 25-41. , R. S. J. Frackowiak, K. J. Fristen, C. D. Frith, R. J. Dolan, & J. C. Mazziotta (Eds.). San Diego: Academic Press
Friston, K.J., Buechel, C., Fink, G.R., Morris, J., Rolls, E., Dolan, R.J., Psychophysiological and modulatory interactions in neuroimaging (1997) Neuroimage, 6, pp. 218-229
Giacino, J.T., Ashwal, S., Childs, N., Cranford, R., Jennett, B., Katz, D.I., The minimally conscious state: Definition and diagnostic criteria (2002) Neurology, 58, pp. 349-353
Hirsch, J., Kamal, A., Rodriguez-Moreno, D., Petrovich, N., Giacino, J., Plum, F., Schiff, N., FMRI reveals intact cognitive systems in two minimally conscious patients (2001) Society for Neuroscience 30th Annual Meeting (52914)
Holmes, A., Friston, K., Generalisability, random effects and population inference (1998) Neuroimage, 7, p. 754
Klein, M., Perception of pain in the persistent vegetative state? (1997) European Journal of Pain, 1, pp. 165-167. , 167-168 discussion
Kotchoubey, B., Lang, S., Herb, E., Maurer, P., Schmalohr, D., Bostanov, V., Birbaumer, N., Stimulus complexity enhances auditory discrimination in patients with extremely severe brain injuries (2003) Neuroscience Letters, 352, pp. 129-132
Laureys, S., Faymonville, M.E., Degueldre, C., Fiore, G.D., Damas, P., Lambermont, B., Auditory processing in the vegetative state (2000) Brain, 123, pp. 1589-1601
Laureys, S., Faymonville, M.E., Peigneux, P., Damas, P., Lambermont, B., Del Fiore, G., Cortical processing of noxious somatosensory stimuli in the persistent vegetative state (2002) Neuroimage, 17, pp. 732-741
Laureys, S., Perrin, F., Faymonville, M., Schnakers, C., Boly, M., Bartsch, V., Cerebral processing in the minimally conscious state (2004) Neurology, 63, pp. 916-918
McQuillen, M.P., Can people who are unconscious or in the "vegetative state" perceive pain? (1991) Issues in Law & Medicine, 6, pp. 373-383
Menon, D.K., Owen, A.M., Williams, E.J., Minhas, P.S., Allen, C.M., Boniface, S.J., Pickard, J.D., Cortical processing in persistent vegetative state (1998) Lancet, 352, p. 200
Medical aspects of the persistent vegetative state (1) (1994) New England Journal of Medicine, 330, pp. 1499-1508
Owen, A.M., Menon, D.K., Johnsrude, I.S., Bor, D., Scott, S.K., Manly, T., Detecting residual cognitive function in persistent vegetative state (2002) Neurocase, 8, pp. 394-403
Plum, F., Schiff, N., Ribary, U., Llinas, R., Coordinated expression in chronically unconscious persons (1998) Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 353, pp. 1929-1933
Rainville, P., Duncan, G.H., Price, D.D., Carrier, B., Bushnell, M.C., Pain affect encoded in human anterior cingulate but not somatosensory cortex (1997) Science, 277, pp. 968-971
Schiff, N., Ribary, U., Plum, F., Llinas, R., Words without mind (1999) Journal of Cognitive Neuroscience, 11, pp. 650-656
Schiff, N.D., Ribary, U., Moreno, D.R., Beattie, B., Kronberg, E., Blasberg, R., Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain (2002) Brain, 125, pp. 1210-1234
Teasdale, G., Jennett, B., Assessment of coma and impaired consciousness. A practical scale (1974) Lancet, 2, pp. 81-84
