Article (Scientific journals)
Brain function in coma, vegetative state, and related disorders
Laureys, Steven; Owen, Adrian M; Schiff, Nicholas D
2004In The Lancet Neurology, 3 (9), p. 537-546
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Abstract :
[en] We review the nosological criteria and functional neuroanatomical basis for brain death, coma, vegetative state, minimally conscious state, and the locked-in state. Functional neuroimaging is providing new insights into cerebral activity in patients with severe brain damage. Measurements of cerebral metabolism and brain activations in response to sensory stimuli with PET, fMRI, and electrophysiological methods can provide information on the presence, degree, and location of any residual brain function. However, use of these techniques in people with severe brain damage is methodologically complex and needs careful quantitative analysis and interpretation. In addition, ethical frameworks to guide research in these patients must be further developed. At present, clinical examinations identify nosological distinctions needed for accurate diagnosis and prognosis. Neuroimaging techniques remain important tools for clinical research that will extend our understanding of the underlying mechanisms of these disorders.
Disciplines :
Neurology
Author, co-author :
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Owen, Adrian M
Schiff, Nicholas D
Language :
English
Title :
Brain function in coma, vegetative state, and related disorders
Publication date :
September 2004
Journal title :
The Lancet Neurology
ISSN :
1474-4422
eISSN :
1474-4465
Publisher :
Lancet Ltd, London, United Kingdom
Volume :
3
Issue :
9
Pages :
537-546
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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since 29 November 2009

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