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Article (Scientific journals)
Are spatial memories strengthened in the human hippocampus during slow wave sleep?
Peigneux, Philippe  ; Laureys, Steven  ; Fuchs, Sonia et al.
2004 • In Neuron, 44 (3), p. 535-545
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Keywords :
Brain Mapping; Hippocampus/physiology; Positron-Emission Tomography/methods; Humans; Sleep/physiology; Memory/physiology
Abstract :
[en] In rats, the firing sequences observed in hippocampal ensembles during spatial learning are replayed during subsequent sleep, suggesting a role for posttraining sleep periods in the offline processing of spatial memories. Here, using regional cerebral blood flow measurements, we show that, in humans, hippocampal areas that are activated during route learning in a virtual town are likewise activated during subsequent slow wave sleep. Most importantly, we found that the amount of hippocampal activity expressed during slow wave sleep positively correlates with the improvement of performance in route retrieval on the next day. These findings suggest that learning-dependent modulation in hippocampal activity during human sleep reflects the offline processing of recent episodic and spatial memory traces, which eventually leads to the plastic changes underlying the subsequent improvement in performance.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging \u0026 Memory - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Peigneux, Philippe ;  Université de Liège - ULiège > Département des sciences cognitives > Département des sciences cognitives
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Fuchs, Sonia
Collette, Fabienne  ;  Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Perrin, Fabien
Reggers, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - PSYCHO & PSYCHIATRIE T3 -3E
Phillips, Christophe  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Degueldre, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Del Fiore, Guy
Aerts, Joël ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Are spatial memories strengthened in the human hippocampus during slow wave sleep?
Publication date :
28 October 2004
Journal title :
Neuron
ISSN :
0896-6273
eISSN :
1097-4199
Publisher :
Cell Press, Cambridge, United Kingdom
Volume :
44
Issue :
3
Pages :
535-545
Peer reviewed :
Peer Reviewed verified by ORBi
Additional URL :
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique

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