Article (Scientific journals)
Controlled clinical trial of repeated prefrontal tDCS in patients with chronic minimally conscious state.
Thibaut, Aurore; Wannez, Sarah; Donneau, Anne-Françoise et al.
2017In Brain Injury, 31 (4), p. 466-474
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Keywords :
Clinical trial: NCT02019615; Minimally conscious state; brain injury; brain stimulation; disorders of consciousness; tDCS
Abstract :
[en] OBJECTIVES: To assess the effects of repeated transcranial direct current stimulation (tDCS) sessions on the level of consciousness in chronic patients in minimally conscious state (MCS). METHODS: In this randomized double-blind sham-controlled crossover study, we enrolled 16 patients in chronic MCS. For 5 consecutive days, each patient received active or sham tDCS over the left prefrontal cortex (2 mA during 20 min). Consciousness was assessed with the Coma Recovery Scale-Revised (CRS-R) before the first stimulation (baseline), after each stimulation (day 1-day 5) and 1 week after the end of each session (day 12). RESULTS: A treatment effect (p = 0.013; effect size = 0.43) was observed at the end of the active tDCS session (day 5) as well as 1 week after the end of the active tDCS session (day 12; p = 0.002; effect size = 0.57). A longitudinal increase of the CRS-R total scores was identified for the active tDCS session (p < 0.001), while no change was found for the sham session (p = 0.64). Nine patients were identified as responders (56%). CONCLUSION: Our results suggest that repeated (5 days) left prefrontal tDCS improves the recovery of consciousness in some chronic patients in MCS, up to 1 week after the end of the stimulations.
Disciplines :
Neurology
Author, co-author :
Thibaut, Aurore ;  Université de Liège - ULiège > GIGA : Coma Group
Wannez, Sarah ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Donneau, Anne-Françoise 
Chatelle, Camille ;  Université de Liège - ULiège > GIGA : Coma Group
Gosseries, Olivia  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Bruno, Marie-Aurelie
Laureys, Steven  ;  Université de Liège - ULiège > GIGA : Coma Group
Language :
English
Title :
Controlled clinical trial of repeated prefrontal tDCS in patients with chronic minimally conscious state.
Publication date :
2017
Journal title :
Brain Injury
ISSN :
0269-9052
eISSN :
1362-301X
Publisher :
Taylor and Francis, Abingdon, United Kingdom
Volume :
31
Issue :
4
Pages :
466-474
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 January 2019

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