Article (Scientific journals)
Offline persistence of memory-related cerebral activity during active wakefulness
Peigneux, Philippe; Orban, Pierre; Balteau, Evelyne et al.
2006In PLoS Biology, 4 (4), p. 100
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Abstract :
[en] Much remains to be discovered about the fate of recent memories in the human brain. Several studies have reported the reactivation of learning-related cerebral activity during post-training sleep, suggesting that sleep plays a role in the offline processing and consolidation of memory. However, little is known about how new information is maintained and processed during post-training wakefulness before sleep, while the brain is actively engaged in other cognitive activities. We show, using functional magnetic resonance imaging, that brain activity elicited during a new learning episode modulates brain responses to an unrelated cognitive task, during the waking period following the end of training. This post-training activity evolves in learning-related cerebral structures, in which functional connections with other brain regions are gradually established or reinforced. It also correlates with behavioral performance. These processes follow a different time course for hippocampus-dependent and hippocampus-independent memories. Our experimental approach allowed the characterization of the offline evolution of the cerebral correlates of recent memories, without the confounding effect of concurrent practice of the learned material. Results indicate that the human brain has already extensively processed recent memories during the first hours of post-training wakefulness, even when simultaneously coping with unrelated cognitive demands.
Disciplines :
Theoretical & cognitive psychology
Author, co-author :
Peigneux, Philippe ;  Université de Liège - ULiège > Département des sciences cognitives > Département des sciences cognitives
Orban, Pierre ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Balteau, Evelyne ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Degueldre, Christian 
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Offline persistence of memory-related cerebral activity during active wakefulness
Publication date :
April 2006
Journal title :
PLoS Biology
ISSN :
1544-9173
eISSN :
1545-7885
Publisher :
Public Library Science, San Francisco, United States - California
Volume :
4
Issue :
4
Pages :
e100
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 January 2013

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