Therapeutic interventions in patients with prolonged disorders of consciousness.

[en] The management of patients with severe brain injuries and prolonged disorders of consciousness raises important issues particularly with respect to their therapeutic options. The scarcity of treatment options is challenged by new clinical and neuroimaging data indicating that some patients with prolonged disorders of consciousness might benefit from therapeutic interventions, even years after the injury. Most studies of interventions aimed at improving patients' level of consciousness and functional recovery were behavioural and brain imaging open-label trials and case reports, but several randomised controlled trials have been done, particularly focused on the effects of drugs or use of non-invasive brain stimulation. However, only two studies on amantadine and transcranial direct current stimulation provided class II evidence. Although new therapeutic approaches seem to be valuable for patients with prolonged disorders of consciousness, optimised stimulation parameters, alternative drugs, or rehabilitation strategies still need to be tested and validated to improve rehabilitation and the quality of life of these patients.

Disciplines :

Neurology

Author, co-author :

Thibaut, Aurore ; Université de Liège - ULiège > Consciousness-Coma Science Group

Schiff, Nicholas

Giacino, Joseph

LAUREYS, Steven ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Centre intégré pluridisc. étude cerveau-cognition-conscience

Gosseries, Olivia ; Université de Liège - ULiège > Consciousness-Coma Science Group

Language :

English

Title :

Therapeutic interventions in patients with prolonged disorders of consciousness.

Publication date :

June 2019

Journal title :

The Lancet Neurology

ISSN :

1474-4422

eISSN :

1474-4465

Publisher :

The Lancet Publishing Group, United Kingdom

Volume :

Issue :

Pages :

600-614

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 August 2019

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2689 (55 by ULiège)

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4314 (47 by ULiège)

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Scopus citations^®

239

Scopus citations^®
without self-citations

193

OpenCitations

OpenAlex citations

297

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