Article (Scientific journals)
Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis.
Böhm, Julia K; Güting, Helge; Thorn, Sophie et al.
2021In Neurocritical Care, 35 (1), p. 184-196
Peer Reviewed verified by ORBi
 

Files


Full Text
Article_GlobalCharacterisationOfCoagul.pdf
Author postprint (1.31 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Blood Coagulation Disorders/epidemiology/etiology; Blood Coagulation Tests; Brain Injuries, Traumatic/complications; Glasgow Coma Scale; Humans; Prospective Studies; CENTER-TBI; Coagulopathy; Risk factors; Traumatic brain injury
Abstract :
[en] BACKGROUND: Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood. METHODS: This analysis, embedded in the prospective, multi-centred, observational Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, aimed to characterise the coagulopathy of TBI. Emphasis was placed on the acute phase following TBI, primary on subgroups of patients with abnormal coagulation profile within 4 h of admission, and the impact of pre-injury anticoagulant and/or antiplatelet therapy. In order to minimise confounding factors, patients with isolated TBI (iTBI) (n = 598) were selected for this analysis. RESULTS: Haemostatic disorders were observed in approximately 20% of iTBI patients. In a subgroup analysis, patients with pre-injury anticoagulant and/or antiplatelet therapy had a twice exacerbated coagulation profile as likely as those without premedication. This was in turn associated with increased rates of mortality and unfavourable outcome post-injury. A multivariate analysis of iTBI patients without pre-injury anticoagulant therapy identified several independent risk factors for coagulopathy which were present at hospital admission. Glasgow Coma Scale (GCS) less than or equal to 8, base excess (BE) less than or equal to - 6, hypothermia and hypotension increased risk significantly. CONCLUSION: Consideration of these factors enables early prediction and risk stratification of acute coagulopathy after TBI, thus guiding clinical management.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Böhm, Julia K;  Department of Medicine, Faculty of Health, Institute for Research in Operative
Güting, Helge;  Department of Medicine, Faculty of Health, Institute for Research in Operative
Thorn, Sophie;  Emergency and Trauma Centre, Alfred Health, 55 Commercial Road, Melbourne, VIC,
Schäfer, Nadine;  Department of Medicine, Faculty of Health, Institute for Research in Operative
Rambach, Victoria;  Department of Medicine, Faculty of Health, Institute for Research in Operative
Schöchl, Herbert;  Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Academic  ; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research
Grottke, Oliver;  Department of Anaesthesiology, RWTH Aachen University Hospital, Pauwelsstraße 30,
Rossaint, Rolf;  Department of Anaesthesiology, RWTH Aachen University Hospital, Pauwelsstraße 30,
Stanworth, Simon;  NHS Blood and Transplant, Oxford University Hospital NHS Foundation Trust, Headley
Curry, Nicola;  NHS Blood and Transplant, Oxford University Hospital NHS Foundation Trust, Headley
Lefering, Rolf;  Department of Medicine, Faculty of Health, Institute for Research in Operative
Maegele, Marc;  Department of Medicine, Faculty of Health, Institute for Research in Operative  ; Department of Traumatology, Orthopaedic Surgery and Sports Traumatology,
CENTER-TBI Participants and, Investigators
More authors (3 more) Less
Other collaborator :
Åkerlund, Cecilia
Amrein, Krisztina
Andelic, Nada
Andreassen, Lasse
Anke, Audny
Antoni, Anna
Audibert, Gérard
Azouvi, Philippe
Azzolini, Maria Luisa
Bartels, Ronald
Barzó, Pál
Beauvais, Romuald
Beer, Ronny
Bellander, Bo-Michael
Belli, Antonio
Benali, Habib
Berardino, Maurizio
Beretta, Luigi
Blaabjerg, Morten
Bragge, Peter
Brazinova, Alexandra
Brinck, Vibeke
Brooker, Joanne
Brorsson, Camilla
Buki, Andras
Bullinger, Monika
Cabeleira, Manuel
Caccioppola, Alessio
Calappi, Emiliana
Calvi, Maria Rosa
Cameron, Peter
Lozano, Guillermo Carbayo
Carbonara, Marco
Cavallo, Simona
Chevallard, Giorgio
Chieregato, Arturo
Citerio, Giuseppe
Ceyisakar, Iris
Clusmann, Hans
Coburn, Mark
Coles, Jonathan
Cooper, Jamie D
Correia, Marta
Čović, Amra
Curry, Nicola
Czeiter, Endre
Czosnyka, Marek
Dahyot-Fizelier, Claire
Dark, Paul
Dawes, Helen
De Keyser, Véronique ;  Université de Liège - ULiège > Département de Psychologie
Degos, Vincent
Corte, Francesco Della
Boogert, Hugo den
Depreitere, Bart
Đilvesi, Đula
Dixit, Abhishek
Donoghue, Emma
Dreier, Jens
Dulière, Guy-Loup
Ercole, Ari
Esser, Patrick
Ezer, Erzsébet
Fabricius, Martin
Feigin, Valery L
Foks, Kelly
Frisvold, Shirin
Furmanov, Alex
Gagliardo, Pablo
Galanaud, Damien
Gantner, Dashiell
Gao, Guoyi
George, Pradeep
GHUYSEN, Alexandre ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des urgences
Giga, Lelde
Glocker, Ben
Golubovic, Jagoš
Gomez, Pedro A
Gratz, Johannes
Gravesteijn, Benjamin
Grossi, Francesca
Gruen, Russell L
Gupta, Deepak
Haagsma, Juanita A
Haitsma, Iain
Helbok, Raimund
Helseth, Eirik
Horton, Lindsay
Huijben, Jilske
Hutchinson, Peter J
Jacobs, Bram
Jankowski, Stefan
Jarrett, Mike
Jiang, Ji-Yao
Johnson, Faye
Jones, Kelly
Karan, Mladen
Kolias, Angelos G
Kompanje, Erwin
Kondziella, Daniel
Koraropoulos, Evgenios
Koskinen, Lars-Owe
Kovács, Noémi
Kowark, Ana
Lagares, Alfonso
Lanyon, Linda
LAUREYS, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > > Centre du Cerveau²
Lecky, Fiona
LEDOUX, Didier  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Lefering, Rolf
Legrand, Valerie
Lejeune, Aurelie
Levi, Leon
Lightfoot, Roger
Lingsma, Hester
Maas, Andrew I R
Castaño-León, Ana M
Maegele, Marc
Majdan, Marek
Manara, Alex
Manley, Geoffrey
Martino, Costanza
Maréchal, Hugues
Mattern, Julia
McMahon, Catherine
Melegh, Béla
Menon, David
Menovsky, Tomas
Mikolic, Ana
Misset, Benoît ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Muraleedharan, Visakh
Murray, Lynnette
Negru, Ancuta
Nelson, David
Newcombe, Virginia
Nieboer, Daan
Nyirádi, József
Olubukola, Otesile
Oresic, Matej
Ortolano, Fabrizio
Palotie, Aarno
Parizel, Paul M
Payen, Jean-François
Perera, Natascha
Perlbarg, Vincent
Persona, Paolo
Peul, Wilco
Piippo-Karjalainen, Anna
Pirinen, Matti
Ples, Horia
Polinder, Suzanne
Pomposo, Inigo
Posti, Jussi P
Puybasset, Louis
Radoi, Andreea
Ragauskas, Arminas
Raj, Rahul
Rambadagalla, Malinka
Rhodes, Jonathan
Richardson, Sylvia
Richter, Sophie
Ripatti, Samuli
Rocka, Saulius
Roe, Cecilie
Roise, Olav
Rosand, Jonathan
Rosenfeld, Jeffrey V
Rosenlund, Christina
Rosenthal, Guy
Rossaint, Rolf
Rossi, Sandra
Rueckert, Daniel
Rusnák, Martin
Sahuquillo, Juan
Sakowitz, Oliver
Sanchez-Porras, Renan
Sandor, Janos
Schäfer, Nadine
Schmidt, Silke
Schoechl, Herbert
Schoonman, Guus
Schou, Rico Frederik
Schwendenwein, Elisabeth
Sewalt, Charlie
Skandsen, Toril
Smielewski, Peter
Sorinola, Abayomi
Stamatakis, Emmanuel
Stanworth, Simon
Stevens, Robert
Stewart, William
Steyerberg, Ewout W
Stocchetti, Nino
Sundström, Nina
Synnot, Anneliese
Takala, Riikka
Tamás, Viktória
Tamosuitis, Tomas
Taylor, Mark Steven
Ao, Braden Te
Tenovuo, Olli
Theadom, Alice
Thomas, Matt
Tibboel, Dick
Timmers, Marjolein
Tolias, Christos
Trapani, Tony
Tudora, Cristina Maria
Unterberg, Andreas
Vajkoczy, Peter
Vallance, Shirley
Valeinis, Egils
Vámos, Zoltán
van der Jagt, Mathieu
Van der Steen, Gregory
van der Naalt, Joukje
van Dijck, Jeroen T J M
van Essen, Thomas A
Van Hecke, Wim
van Heugten, Caroline
Van Praag, Dominique
Vyvere, Thijs Vande
van Wijk, Roel P J
Vargiolu, Alessia
Vega, Emmanuel
Velt, Kimberley
Verheyden, Jan
Vespa, Paul M
Vik, Anne
Vilcinis, Rimantas
Volovici, Victor
von Steinbüchel, Nicole
Voormolen, Daphne
Vulekovic, Petar
Wang, Kevin K W
Wiegers, Eveline
Williams, Guy
Wilson, Lindsay
Winzeck, Stefan
Wolf, Stefan
Yang, Zhihui
Ylén, Peter
Younsi, Alexander
Zeiler, Frederick A
Zelinkova, Veronika
Ziverte, Agate
Zoerle, Tommaso
More authors (237 more) Less
Language :
English
Title :
Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis.
Publication date :
August 2021
Journal title :
Neurocritical Care
ISSN :
1541-6933
eISSN :
1556-0961
Publisher :
Humana Press, Us
Volume :
35
Issue :
1
Pages :
184-196
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
© 2020. The Author(s).
Available on ORBi :
since 27 March 2022

Statistics


Number of views
120 (1 by ULiège)
Number of downloads
99 (1 by ULiège)

Scopus citations®
 
19
Scopus citations®
without self-citations
14
OpenCitations
 
13

Bibliography


Similar publications



Contact ORBi