Article (Scientific journals)
Assessing Command-Following and Communication With Vibro-Tactile P300 Brain-Computer Interface Tools in Patients With Unresponsive Wakefulness Syndrome.
Guger, Christoph; Spataro, Rossella; Pellas, Frederic et al.
2018In Frontiers in Neuroscience, 12, p. 423
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Keywords :
brain computer interface; communication; evoked potentials; unresponsive wakefulness syndrome; vegetative state; vibro-tactile P300
Abstract :
[en] Persons diagnosed with disorders of consciousness (DOC) typically suffer from motor disablities, and thus assessing their spared cognitive abilities can be difficult. Recent research from several groups has shown that non-invasive brain-computer interface (BCI) technology can provide assessments of these patients' cognitive function that can supplement information provided through conventional behavioral assessment methods. In rare cases, BCIs may provide a binary communication mechanism. Here, we present results from a vibrotactile BCI assessment aiming at detecting command-following and communication in 12 unresponsive wakefulness syndrome (UWS) patients. Two different paradigms were administered at least once for every patient: (i) VT2 with two vibro-tactile stimulators fixed on the patient's left and right wrists and (ii) VT3 with three vibro-tactile stimulators fixed on both wrists and on the back. The patients were instructed to mentally count either the stimuli on the left or right wrist, which may elicit a robust P300 for the target wrist only. The EEG data from -100 to +600 ms around each stimulus were extracted and sub-divided into 8 data segments. This data was classified with linear discriminant analysis (using a 10 x 10 cross validation) and used to calibrate a BCI to assess command following and YES/NO communication abilities. The grand average VT2 accuracy across all patients was 38.3%, and the VT3 accuracy was 26.3%. Two patients achieved VT3 accuracy >/=80% and went through communication testing. One of these patients answered 4 out of 5 questions correctly in session 1, whereas the other patient answered 6/10 and 7/10 questions correctly in sessions 2 and 4. In 6 other patients, the VT2 or VT3 accuracy was above the significance threshold of 23% for at least one run, while in 4 patients, the accuracy was always below this threshold. The study highlights the importance of repeating EEG assessments to increase the chance of detecting command-following in patients with severe brain injury. Furthermore, the study shows that BCI technology can test command following in chronic UWS patients and can allow some of these patients to answer YES/NO questions.
Disciplines :
Neurology
Author, co-author :
Guger, Christoph
Spataro, Rossella
Pellas, Frederic
Allison, Brendan Z.
Heilinger, Alexander
Ortner, Rupert
Cho, Woosang
Xu, Ren
La Bella, Vincenzo
Edlinger, Gunter
Annen, Jitka  ;  Université de Liège - ULiège > GIGA : Coma Group
Mandala, Giorgio
Chatelle, Camille  ;  Université de Liège - ULiège > GIGA : Coma Group
Laureys, Steven   ;  Université de Liège - ULiège > GIGA : Coma Group
More authors (4 more) Less
 These authors have contributed equally to this work.
Language :
English
Title :
Assessing Command-Following and Communication With Vibro-Tactile P300 Brain-Computer Interface Tools in Patients With Unresponsive Wakefulness Syndrome.
Publication date :
2018
Journal title :
Frontiers in Neuroscience
ISSN :
1662-4548
eISSN :
1662-453X
Publisher :
Frontiers Media S.A., Switzerland
Volume :
12
Pages :
423
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 January 2019

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