Article (Scientific journals)
Consciousness supporting networks
Demertzi, Athina; Soddu, Andrea; Laureys, Steven
2013In Current Opinion in Neurobiology, 23 (2), p. 239–244
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Abstract :
[en] Functional neuroimaging shows that patients with disorders of consciousness exhibit disrupted system-level functional connectivity. Unresponsive/’’vegetative state’’ patients preserve wakefulness networks of brainstem and basal forebrain but the cerebral networks accounting for external perceptual awareness and internal self-related mentation are disrupted. Specifically, the ‘external awareness’ network encompassing lateral fronto-temporo-parietal cortices bilaterally, and the ‘internal awareness’ network including midline anterior cingulate/mesiofrontal and posterior cingulate/ precuneal cortices, are functionally disconnected. By contrast, patients in minimally conscious state ‘minus’, who show nonreflex behaviors, are characterized by right-lateralized recovery of the external awareness network. Similarly, patients who evolve to minimally conscious state ‘plus’ and respond to commands recover the dominant left-lateralized language network. Now, the use of active experimental paradigms targeting at detecting motor-independent signs of awareness or even establishing communication with these patients, challenge these two clinical boundaries. Such advances are naturally accompanied by legitimate neuroscientific and ethical queries demanding our attention on the medical implementations of this new knowledge.
Disciplines :
Neurosciences & behavior
Neurology
Author, co-author :
Demertzi, Athina  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Soddu, Andrea ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Consciousness supporting networks
Publication date :
January 2013
Journal title :
Current Opinion in Neurobiology
ISSN :
0959-4388
Publisher :
Elsevier Science
Volume :
23
Issue :
2
Pages :
239–244
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 06 July 2013

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