Article (Scientific journals)
Multifaceted Brain Networks Reconfiguration in Disorders of Consciousness Uncovered by Co-Activation Patterns
Di Perri, Carol; Amico, Enrico; Heine, Lizette et al.
2018In Human Brain Mapping
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Keywords :
pathological hyperconnectivity; dynamic network interactions; co-activation patterns; unresponsive wakefulness syndrome
Abstract :
[en] Introduction: Given that recent research has shown that functional connectivity is not a static phenomenon, we aim to investigate the dynamic properties of the default mode network’s (DMN) connectivity in patients with disorders of consciousness. Methods: Resting-state fMRI volumes of a convenience sample of 17 patients in unresponsive wakefulness syndrome (UWS) and controls were reduced to a spatiotemporal point process by selecting critical time points in the posterior cingulate cortex (PCC). Spatial clustering was performed on the extracted PCC time frames to obtain 8 different co-activation patterns (CAPs). We investigated spatial connectivity patterns positively and negatively correlated with PCC using both CAPs and standard stationary method. We calculated CAPs occurrences and the total number of frames. Results: Compared to controls, patients showed (i) decreased within-network positive correlations and between-network negative correlations, (ii) emergence of “pathological” within-network negative correlations and between-network positive correlations (better defined with CAPs), and (iii) “pathological” increases in within-network positive correlations and between-network negative correlations (only detectable using CAPs). Patients showed decreased occurrence of DMN-like CAPs (1–2) compared to controls. No between-group differences were observed in the total number of frames Conclusion: CAPs reveal at a more fine-grained level the multifaceted spatial connectivity reconfiguration following the DMN disruption in UWS patients, which is more complex than previously thought and suggests alternative anatomical substrates for consciousness. BOLD fluctuations do not seem to differ between patients and controls, suggesting that BOLD response represents an intrinsic feature of the signal, and therefore that spatial configuration is more important for consciousness than BOLD activation itself.
Research center :
GIGA-Consciousness
Disciplines :
Neurology
Author, co-author :
Di Perri, Carol  ;  Université de Liège - ULiège > GIGA : Coma Group
Amico, Enrico 
Heine, Lizette ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Annen, Jitka  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Martial, Charlotte  ;  Université de Liège - ULiège > GIGA : Coma Group
Larroque, Stephen Karl  ;  Université de Liège - ULiège > GIGA - MASSGPFS
Soddu, Andrea ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Marinazzo, Daniele;  University of Ghent, Ghent, Belgium > Department of Data-analysis
LAUREYS, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie
 These authors have contributed equally to this work.
Language :
English
Title :
Multifaceted Brain Networks Reconfiguration in Disorders of Consciousness Uncovered by Co-Activation Patterns
Publication date :
January 2018
Journal title :
Human Brain Mapping
ISSN :
1065-9471
eISSN :
1097-0193
Publisher :
Wiley Liss, New York, United States - New York
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Luminous
DG RDT - Commission Européenne. Direction Générale de la Recherche et de l'Innovation [BE]
Center-TBI
Human Brain Project (HBP)
JSMF - James S McDonnell Foundation [US-MO] [US-MO]
ASE - Agence Spatiale Européenne [FR]
BELSPO - Politique scientifique fédérale [BE]
FERB - Fondazione Europea Ricerca Biomedica [IT]
Laboratórios Bial [PT]
Wallonia-Brussels Federation Concerted Research Action
MSF - Mind Science Foundation [US-TX] [US-TX]
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since 12 October 2017

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