Article (Scientific journals)
Disruption in structural-functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness.
Panda, Rajanikant; Thibaut, Aurore; Lopez-Gonzalez, Ane et al.
2022In eLife, 11
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Keywords :
Brain; Consciousness/physiology; Frontal Lobe/diagnostic imaging; Humans; Magnetic Resonance Imaging; Persistent Vegetative State; computational biology; disorders of consciousness; dynamic connectivity; eigenmodes; fMRI; global neuronal workspace; human; mesocircuit; systems biology
Abstract :
[en] Understanding recovery of consciousness and elucidating its underlying mechanism is believed to be crucial in the field of basic neuroscience and medicine. Ideas such as the global neuronal workspace (GNW) and the mesocircuit theory hypothesize that failure of recovery in conscious states coincide with loss of connectivity between subcortical and frontoparietal areas, a loss of the repertoire of functional networks states and metastable brain activation. We adopted a time-resolved functional connectivity framework to explore these ideas and assessed the repertoire of functional network states as a potential marker of consciousness and its potential ability to tell apart patients in the unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). In addition, the prediction of these functional network states by underlying hidden spatial patterns in the anatomical network, that is so-called eigenmodes, was supplemented as potential markers. By analysing time-resolved functional connectivity from functional MRI data, we demonstrated a reduction of metastability and functional network repertoire in UWS compared to MCS patients. This was expressed in terms of diminished dwell times and loss of nonstationarity in the default mode network and subcortical fronto-temporoparietal network in UWS compared to MCS patients. We further demonstrated that these findings co-occurred with a loss of dynamic interplay between structural eigenmodes and emerging time-resolved functional connectivity in UWS. These results are, amongst others, in support of the GNW theory and the mesocircuit hypothesis, underpinning the role of time-resolved thalamo-cortical connections and metastability in the recovery of consciousness.
Disciplines :
Neurosciences & behavior
Author, co-author :
Panda, Rajanikant  ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Thibaut, Aurore ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Lopez-Gonzalez, Ane;  Computational Neuroscience Group, Center for Brain and Cognition, Universitat
Escrichs, Anira ;  Computational Neuroscience Group, Center for Brain and Cognition, Universitat
Bahri, Mohamed Ali;  GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège,
Hillebrand, Arjan ;  Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Clinical
Deco, Gustavo;  Computational Neuroscience Group, Center for Brain and Cognition, Universitat  ; Institució Catalana de la Recerca i Estudis Avançats (ICREA), Barcelona, Spain. ; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain  ; School of Psychological Sciences, Monash University, Melbourne, Australia.
Laureys, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > > Centre du Cerveau² ; CERVO Research Center, Laval University, Québec, Canada.
Gosseries, Olivia  ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Annen, Jitka   ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Tewarie, Prejaas  ;  Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Clinical  ; Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University
 These authors have contributed equally to this work.
Language :
English
Title :
Disruption in structural-functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness.
Publication date :
02 August 2022
Journal title :
eLife
eISSN :
2050-084X
Publisher :
eLife Sciences Publications, Gb
Volume :
11
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
© 2022, Panda et al.
Available on ORBi :
since 16 January 2023

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