Article (Scientific journals)
Assessment of consciousness with electrophysiological and neurological imaging techniques.
Bruno, Marie-Aurélie; Gosseries, Olivia; Ledoux, Didier et al.
2011In Current Opinion in Critical Care
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Abstract :
[en] PURPOSE OF REVIEW: Brain MRI (diffusion tensor imaging and spectroscopy) and functional neuroimaging (PET, functional MRI, EEG and evoked potential studies) are changing our understanding of patients with disorders of consciousness encountered after coma such as the 'vegetative' or minimally conscious states. RECENT FINDINGS: Increasing evidence from functional neuroimaging and electrophysiology demonstrates some residual cognitive processing in a subgroup of patients who clinically fail to show any response to commands, leading to the recent proposal of 'unresponsive wakefulness syndrome' as an alternative name for patients previously coined 'vegetative' or 'apallic'. SUMMARY: Consciousness can be viewed as the emergent property of the collective behavior of widespread thalamocortical frontoparietal network connectivity. Data from physiological, pharmacological and pathological alterations of consciousness provide evidence in favor of this hypothesis. Increasing our understanding of the neural correlates of consciousness is helping clinicians to do a better job in terms of diagnosis, prognosis and finally treatment and drug development for these severely brain-damaged patients. The current challenge remains to continue translating this research from the bench to the bedside. Only well controlled large multicentric neuroimaging and electrophysiology studies will enable to identify which paraclinical diagnostic or prognostic test is necessary for our routine evidence-based assessment of individuals with disorders of consciousness.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Bruno, Marie-Aurélie  ;  Université de Liège - ULiège > Centre de recherches du cyclotron > Coma science group
Gosseries, Olivia   ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Ledoux, Didier  ;  Centre Hospitalier Universitaire de Liège - CHU > Centre de Recherches du Cyclotron - coma group > Soins intensifs
Hustinx, Roland  ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Laureys, Steven  ;  Université de Liège - ULiège > Coma science Group > Centre de recherches du cyclotron - Département des sciences cliniques
 These authors have contributed equally to this work.
Language :
English
Title :
Assessment of consciousness with electrophysiological and neurological imaging techniques.
Publication date :
2011
Journal title :
Current Opinion in Critical Care
ISSN :
1070-5295
eISSN :
1531-7072
Publisher :
Lippincott Williams & Wilkins, Hagerstown, United States - Maryland
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
JSMF - James S McDonnell Foundation [US-MO]
MSF - Mind Science Foundation [US-TX]
European Commission (Mindbridge, DISCOS, DECODER and COST)
Concerted Research Action (ARC 06/11-340).
Available on ORBi :
since 06 January 2011

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