White Matter Changes in Comatose Survivors of Anoxic Ischemic Encephalopathy and Traumatic Brain Injury: Comparative Diffusion-Tensor Imaging Study

Van Der Eerden, Anke; Khalilzadeh, Omid; Perlbarg, Vincent; Dinkel, Julien; Sanchez, Paola; Vos, Pieter; Luyt, Charles-Edouard; Stevens, Robert; Menjot de Champfleur, Nicolas; Delmaire, Christine; Tollard, Eleonore; Gupta, Rajiv; Dormont, Didier; Laureys, Steven; Benali, Habib; VANHAUDENHUYSE, Audrey; Galanaud, Damien; Puybasset, Louis

doi:10.1148/radiol.13122720

Article (Scientific journals)

White Matter Changes in Comatose Survivors of Anoxic Ischemic Encephalopathy and Traumatic Brain Injury: Comparative Diffusion-Tensor Imaging Study

Van Der Eerden, Anke; Khalilzadeh, Omid; Perlbarg, Vincent et al.

2014 • In Radiology, 270

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/162979

DOI
10.1148/radiol.13122720

PubMed
24471392

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Abstract :

[en] Purpose:To analyze white matter pathologic abnormalities by using diffusion-tensor (DT) imaging in a multicenter prospective cohort of comatose patients following cardiac arrest or traumatic brain injury (TBI). Materials and Methods: Institutional review board approval and informed consent from proxies and control subjects were obtained. DT imaging was performed 5–57 days after insult in 49 cardiac arrest and 40 TBI patients. To control for DT imaging–processing variability, patients’ values were normalized to those of 111 control subjects. Automated segmentation software calculated normalized axial diffusivity (λ1) and radial diffusivity (λ) in 19 predefined white matter regions of interest (ROIs). DT imaging variables were compared by using general linear modeling, and side-to-side Pearson correlation coefficients were calculated. P values were corrected for multiple testing (Bonferroni). Results:In central white matter, λ1 differed from that in control subjects in six of seven TBI ROIs and five of seven cardiac arrest ROIs (all P < .01). The λ differed from that in control subjects in all ROIs in both patient groups (P < .01). In hemispheres, λ1 was decreased compared with that in control subjects in three of 12 TBI ROIs (P < .05) and nine of 12 cardiac arrest ROIs (P < .01). The λ was increased in all TBI ROIs (P < .01) and in seven of 12 cardiac arrest ROIs (P < .05). Cerebral hemisphere λ1 was lower in cardiac arrest than in TBI in six of 12 ROIs (P < .01), while λ was higher in TBI than in cardiac arrest in eight of 12 ROIs (P < .01). Diffusivity values were symmetrically distributed in cardiac arrest (P < .001 for side-to-side correlation) but not in TBI patients. Conclusion:DT imaging findings are consistent with the known predominance of cerebral hemisphere axonal injury in cardiac arrest and chiefly central myelin injury in TBI. This consistency supports the validity of DT imaging for differentiating axon and myelin damage in vivo in humans.

Research center :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurology

Author, co-author :

Van Der Eerden, Anke

Khalilzadeh, Omid

Perlbarg, Vincent

Dinkel, Julien

Sanchez, Paola

Vos, Pieter

Luyt, Charles-Edouard

Stevens, Robert

Menjot de Champfleur, Nicolas

Delmaire, Christine

More authors (8 more)

Language :

English

Title :

White Matter Changes in Comatose Survivors of Anoxic Ischemic Encephalopathy and Traumatic Brain Injury: Comparative Diffusion-Tensor Imaging Study

Publication date :

February 2014

Journal title :

Radiology

ISSN :

0033-8419

eISSN :

1527-1315

Publisher :

Radiological Society of North America, Easton, United States - Pennsylvania

Volume :

270

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://pubs.rsna.org/doi/abs/10.1148/radiol.13122720

Available on ORBi :

since 10 February 2014

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