Degotte, G., Pirotte, B., Francotte, P., & Frederich, M. (In press). Potential of caffeic acid derivatives as antimalarial leads. Letters in Drug Design and Discovery.
Malaria remains one of the deadliest infectious disease in 2021. Indeed, this infection, mostly c...
Bonnet, O., Beniddir, M. A., Champy, P., Kagisha, V., Nyirimigabo, A., Hamann, C., Jgerenaia, G., Ledoux, A., Tiabou Tchinda, A., Angenot, L., & Frederich, M. (2022). Exploration by molecular networking of Strychnos alkaloids reveals the unexpected occurrence of strychnine in seven Strychnos species. Toxicon. doi:10.1016/j.toxicon.2022.06.002
Introduction Plants of the genus Strychnos , which include about 200 species, are used for multi...
Jgerenaia, G., Sulakvelidze, M., Novikova, Z., Gogitidze, N., Mushkiashvili, N., Mulkijanyan, K., Frederich, M., & Mskhiladze, L. (2022). PHARMACOLOGICAL ASSESSMENT OF CONSTITUENTS OF SPECIES ALLIUM SAXATILE AND ALLIUM PONTICUM GROWING IN GEORGIA. EXPERIMENTAL & CLINICAL MEDICINE GEORGIA. doi:10.52340/jecm.2022.06.04
The present study aimed to estimate the pharmacological potency of products from some Allium spec...
Stankovic, M., Baptista, P., Carillo, P., Păltine, R., Ielciu, I.* , Hangan, D., Nicula, M., Pa, E., Angenot, L., Tits, M., Moca, A., Babotă, M., Frumuzachi, O., Tămaş, M., Crişan, G., & Frederich, M. (2022). Biological Activities of Some Isoquinoline Alkaloids from Fumaria schleicheri Soy. Will. Plants. doi:10.3390/plants11091202
This article is an open access article distributed under the terms and conditions of the Creative...
Leka, K., Hamann, C., Desdemoustier, P., Frederich, M., Garigliany, M.-M., & Ledoux, A. (2022). In vitro antiviral activity against SARS-CoV-2 of common herbal medicinal extracts and their bioactive compounds. Phytotherapy Research. doi:10.1002/ptr.7463
Fall, F., Coelho Cristino Mamede, L. C., Schioppa, L., Ledoux, A., De Tullio, P., Michels, P., Frederich, M., & Quetin-Leclercq, J. (19 March 2022). Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery. Metabolomics, 18 (4), 20. doi:10.1007/s11306-022-01880-0
[en] BACKGROUND: Trypanosoma brucei is the causative agent of Human African Trypanosomiasis (also...
Ledoux, A., Leka, K., Bonnet, O., Blanquer, A., Tiabou Tchinda, A., Mirowski, P., Figueiredo, P., Desmecht, D., Garigliany, M.-M., & Frederich, M. (10 January 2022). In vitro antiviral activity against SARS-CoV-2 of 28 Strychnos extracts. Phytotherapy Research, 1 (3). doi:10.1002/ptr.7394
Danthine, S., Aman, P., Jansen, O., Ducrey, A., Richel, A., Lognay, G., Maesen, P., Mutwale Kapepula, P., Mouithys-Mickalad, A., Franck, T., & Frederich, M. (2022). Prunella vulgaris L. seeds: a promising source of lipids, proteins, and original phenolic compounds presenting high antioxidant and anti-inflammatory activity. Biotechnologie, Agronomie, Société et Environnement, 26 (1), 1-15. doi:10.25518/1780-4507.19412
Description of the subject. Prunella vulgaris L. (Lamiaceae) is an edible herb used in Europe and...
Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (2021). Polyhydroxybenzoic acid derivatives as potential new antimalarial agents. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. doi:10.1002/ardp.202100190
With more than 200 million cases and 400,000 related deaths, malaria remains one of the deadliest...
Ledoux, A., Bériot, D., Coelho Cristino Mamede, L. C., Desdemoustier, P., Detroz, F., Jansen, O., Frederich, M., & Maquoi, E. (2021). Cytotoxicity of Poupartone B, an Alkyl Cyclohexenone Derivative from Poupartia borbonica, against Human Cancer Cell Lines. Planta Medica. doi:10.1055/a-1532-2384
Tomani, J. C. D., Bonnet, O., Nyirimigabo, A., Deschamps, W., Tchinda, A. T., Jansen, O., Ledoux, A., Mukazayire, M.-J., Vanhamme, L., Frederich, M., Muganga, R., & Souopgui, J. (10 May 2021). In Vitro Antiplasmodial and Cytotoxic Activities of Compounds from the Roots of Eriosema montanum Baker f. (Fabaceae). Molecules, 26 (9), 2795. doi:10.3390/molecules26092795
Malaria remains one of the leading causes of death in sub-Saharan Africa, ranked in thetop three ...
Kowa, T., Jansen, O., Ledoux, A., Coelho Cristino Mamede, L. C., Wabo, H., Tchinda Tiabou, A., Genta-Jouve, G., & Frederich, M. (2021). Bioassay-guided isolation of vilasinin–type limonoids and phenyl alkene from the leaves of Trichilia gilgiana and their antiplasmodial activities. Natural Product Research. doi:10.1080/14786419.2021.1920017
Degotte, G., Pirotte, B., Francotte, P., & Frederich, M. (2021). Overview of natural antiplasmodials from the last decade to inspire medicinal chemistry. Current Medicinal Chemistry. doi:10.2174/0929867328666210329112354
Background: Despite the major advances in the fight against this parasitic disease, malaria remai...
Toukam, P. D., Kom, C. W., Tchamgoué, A. D., Doupno, E. A. K., Lame, Y., Yamthé, L. R. T., Kopa Kowa, T., Tchinda, A. T., Frederich, M., Mbafor, J. T., & De Théodore Atchadé, A. (2021). A new isoquinoline and ceramide from the stem barks of Discoglypremna caloneura (Pax) Prain (Euphorbiaceae) with antiproteinase and cytotoxic activities. Natural Product Research, 1-9. doi:10.1080/14786419.2021.1890073
Two new compounds, an isoquinoline (1) and caloneuramide (2), a ceramide were isolated from the s...
Kagisha, V., Marini Djang'Eing'A, R., Muganga, R., Bonnet, O., Tchinda, A. T., Jansen, O., Tomani, J. C., Njakarinala, R., Ledoux, A., Nyirimigabo, A., & Frederich, M. (2021). Pentas longiflora Oliv. (Rubiaceae), a plant used in the treatment of Pityriasis Versicolor in Rwanda: Chemical composition and standardization of leaves and roots. Fitoterapia, 153, 104974. doi:10.1016/j.fitote.2021.104974
In Rwanda, the roots of Pentas longiflora Oliv. (Rubiaceae) have been used for a long time to tre...
Kapepula, P. M., Mungitshi, P. M., Tshitenge, D. T., Franck, T., Ngoyi, D. M., Kalenda, P. D. T., Tits, M., Frederich, M., Ngombe, N. K., & Mouithys-Mickalad, A. (2021). Microscopic Characteristics , Chromatographic Profiles and Inhibition of Peroxidase Activity of the Leaves of Manihot esculenta and Manihot glaziovii , Consumed as Traditional Vegetables. Journal of Biosciences and Medicines, 9, 59--73. doi:10.4236/jbm.2021.99006
Methanolic extracts from the leaves of Manihot esculenta (Two cultivars) and Manihot glaziovii, c...
Ma'mag, L. K., Zintchem, A. A. A., Théodora, K. K., Théodore, A. A. D., lauve, T. Y., Frederich, M., Bikobo, D. S. N., & Pegnyemb, D. E. (2021). Antiplasmodial and antileishmanial inhibitory activity of triterpenes and steroidal alkaloid from the leaves of Funtumia elastica (Preuss) Stapf (Apocynaceae). Fitoterapia, 104869. doi:10.1016/j.fitote.2021.104869
The phytochemical study of leaves of Funtumia elastica led to the isolation of three undescribed ...
Nea, F., Bitchi, M. B., Genva, M., Ledoux, A., Tchinda Tiabou, A., Damblon, C., Frederich, M., Tonzibo, Z. F., & Fauconnier, M.-L. (2021). Phytochemical investigation and biological activities of Lantana rhodesiensis. Molecules, 26 (4), 846. doi:10.3390/molecules26040846
Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabe...
Saive, M.* , Genva, M.* , Istasse, T., Frederich, M., Maes, C., & Fauconnier, M.-L. (18 September 2020). Identification of a proanthocyanidin from Litchi chinensis Sonn. root with anti-tyrosinase and antioxidant activity. Biomolecules, 10 (9), 1347. doi:10.3390/biom10091347
This work follows an ethnobotanical study that took place in the island of Mayotte (France), whic...
Kagisha, V., Frederich, M., Ledoux, A., Jansen, O., NYIRIMIGABO, A., MUGANGA, R., & Marini Djang'Eing'A, R. (10 June 2020). HPLC-UV Method for Standardization of Neorautanenia mitis, an African Plant Used in an Anti-Scabies Ointment. Revista Brasileira de Farmacognosia, 30 (4), 582-587. doi:10.1007/s43450-020-00070-0
An HPLC-UV method for standardization of the methanol-soluble extracts from tubers of Neorautanen...
Ledoux, A., Coelho Cristino Mamede, L. C., Palazzo, C., Furst, T., Jansen, O., De Tullio, P., Kagisha, V., Pendeville-Samain, H., Fillet, M., Piel, G., & Frederich, M. (18 May 2020). Heparin-Coated Liposomes Improve Antiplasmodial Activity and Reduce the Toxicity of Poupartone B. Planta Medica International Open, 7 (e), 73–80. doi:10.1055/a-1158-0569
Poupartone B is an alkyl cyclohexenone derivative isolated from Poupartia borbonica. This compoun...
Catteau, L., Schioppa, L., Beaufay, C., Girardi, C., Hérent, M.-F., Frederich, M., & Quetin-Leclercq, J. (2020). Antiprotozoal activities of Triterpenic Acids and Ester Derivatives Isolated from the Leaves of Vitellaria paradoxa. Planta Medica. doi:10.1055/a-1286-1879
Leaves of Vitellaria paradoxa, also called "Shea butter tree", are used in traditional medicine t...
Coelho Cristino Mamede, L. C., Ledoux, A., Jansen, O., & Frederich, M. (2020). Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents. Planta Medica, 86 (9), 585-618. doi:10.1055/a-1148-9000
Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundre...
Gerometta, E., Grondin, I., Smadja, J., Frederich, M., & Gauvin-Bialecki, A. (2020). A review of traditional uses, phytochemistry and pharmacology of the genus Indigofera. Journal of Ethnopharmacology, 253, 112608. doi:10.1016/j.jep.2020.112608
ETHNOPHARMACOLOGICAL RELEVANCE: Indigofera is the third-largest genus in the family of Fabaceae, ...
Kowa, T., Tchokouaha, L., Nyemb, J.-N., Wabo, H., Tchinda, A., Appiah-Opong, R., Agbor, G., Tane, P., & Frederich, M. (January 2020). Antipromastigote and cytotoxic activities of some chemical constituents of Hypericum lanceolatum Lam. Journal of Applied Pharmaceutical Science, 10, 26-32. doi:10.7324/JAPS.2020.101004
Phytochemical investigation of the ethanol extract of the stem bark of Hypericum lanceolatum Lam....
Mahadeo, K., Grondin, I., Herbette, G., Palama, T. L., Bouchemal, N., Soulange, J., Laulloo, S. J., Sadeyen, J., Humeau, L., Frederich, M., Gauvin-Bialecki, A., & Kodja, H. (2020). A 1H NMR-based metabolomic approach to study the production of antimalarial compounds from Psiadia arguta leaves (pers.) voigt. Phytochemistry, 176, 112401. doi:10.1016/j.phytochem.2020.112401
Psiadia arguta (Asteraceae) is endemic to the island of Mauritius in the Indian Ocean. The specie...
Mavungu Landu, D. J., Frederich, M., Manzambi Kuwekita, J., Bongo-Pasi Nswe, C., Mbinze Kindenge, J., Liégeois, S., Kalenda Tshilombo, N., Mineze Kwete Minga, Ciza Hamuli, P., Hubert, P., & Marini Djang'Eing'A, R. (2020). Quality of antimalarials in Kinshasa peri-urban areas with regard to local pharmaceutical legislation and regulation. International Health, 12 (4), 253–263. doi:10.1093/inthealth/ihz070
Background: In the context of old pharmaceutical legislation and regulations not adapted to curre...
Mavungu Landu, D. J., Marini Djang'Eing'A, R., Hubert, P., Frederich, M., Michel, B., Gretry, L., Messina Ndzomo, J. P., Bruyère, O., Reginster, J.-Y., & Manzambi Kuwekita, J. (2020). Les déterminants de l’accès à des médicaments antipaludiques de qualité en territoires périurbains africains : résultats d’une enquête menée à Kinshasa (Congo). Journal d’Épidémiologie et de Santé Publique, 21, 85-100.
Contexte : A Kinshasa, l’indisponibilité des antipaludiques dans les établissements de santé a fa...
Muganga, R., Bero, J., Quetin-Leclercq, J., Angenot, L., Tits, M., Mouithys-Mickalad, A., Franck, T., & Frederich, M. (2020). In vitro Antileishmanial, Antitrypanosomal, and Anti-inflammatory- like Activity of Terminalia mollis Root Bark. Planta Medica, efirst. doi:10.1055/a-1260-6382
This study aims at determining the in vitro antitrypanosomal, antileishmanial, antioxidant, and a...
Saive, M., Frederich, M., & Fauconnier, M.-L. (2020). Plants used in traditional medicine in the Comoros archipelago: a review. Biotechnologie, Agronomie, Société et Environnement, 24 (2), 117-141. doi:10.25518/1780-4507.18553
In the Comoros archipelago, as in many places in Africa, traditional medicine is the first reflex...
Tanoh, A. E., Blanchard Boué, G., Nea, F., Genva, M., Wognin, E. L., Ledoux, A., Martin, H., Tonzibo, Z. F., Frederich, M., & Fauconnier, M.-L. (2020). Seasonal effect on the chemical composition, insecticidal properties and other biological activities of Zanthoxylum leprieurii Guill. & Perr. essential oils. Foods, 9 (5), 550. doi:10.3390/foods9050550
This study focused, for the first time, on the evaluation of the seasonal effect on the chemical ...
Tomani, J. C. D., Kagisha, V., Tchinda, A. T., Jansen, O., Ledoux, A., Vanhamme, L., Frederich, M., Muganga, R., & Souopgui, J. (2020). The Inhibition of NLRP3 Inflammasome and IL-6 Production by Hibiscus noldeae Baker f. Derived Constituents Provides a Link to Its Anti-Inflammatory Therapeutic Potentials. Molecules, 25 (20), 4693. doi:10.3390/molecules25204693
The activation of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome and/or i...
Kpadonou, D., Kpoviessi, S., Bero, J., Agbani, P., Gbaguidi, F., Kpadonou-Kpoviessi, B., Sinsin, B., Frederich, M., & Quetin-Leclercq, J. (September 2019). Chemical composition, in vitro antioxidant and antiparasitic properties of the essential oils of three plants used in traditional medicine in Benin. Journal of Medicinal Plant Research, 13 (6), 384-395. doi:10.5897/JMPR2019.6791
Assaidi, A., Dib, I., Tits, M., Angenot, L., Bellahcen, S., Bouanani, N., Legssyer, A., Aziz, M., Mekhfi, H., Bnouham, M., Frederich, M., & Ziyyat, A. (2019). Chenopodium ambrosioides induces an endothelium-dependent relaxation of rat isolated aorta. Journal of Integrative Medicine, 17 (2), 115 - 124. doi:10.1016/j.joim.2019.01.006
Objective This study aims to evaluate the vasodilatory effect of Chenopodium ambrosioides on the ...
Campos, P.-E., Pichon, E., Moriou, C., Clerc, P., Trépos, R., Frederich, M., De Voogd, N., Hellio, C., Gauvin-Bialecki, A., & Al-Mourabit, A. (2019). New Antimalarial and Antimicrobial Tryptamine Derivatives from the Marine Sponge Fascaplysinopsis reticulata. Marine Drugs, 17 (3), 167. doi:10.3390/md17030167
Chemical study of the CH₂Cl₂-MeOH (1:1) extract of the sponge Fascaplysinopsis reticulata collect...
Fox Ramos, A. E., Le Pogam, P., Fox Alcover, C., Otogo N'Nang, E., Cauchie, G., Hazni, H., Awang, K., Breard, D., Echavarren, A. M., Frederich, M., Gaslonde, T., Girardot, M., Grougnet, R., Kirillova, M. S., Kritsanida, M., Lemus, C., Le Ray, A.-M., Lewin, G., Litaudon, M., & Beniddir, M. A. (2019). Collected mass spectrometry data on monoterpene indole alkaloids from natural product chemistry research. Scientific Data, 6 (1), 15. doi:10.1038/s41597-019-0028-3
This Data Descriptor announces the submission to public repositories of the monoterpene indole al...
Huang, Y., Jansen, O., Frederich, M., Mouithys-Mickalad, A., Nys, G., Servais, A.-C., Crommen, J., Jiang, Z., & Fillet, M. (2019). Capillary electrophoresis, high-performance liquid chromatography, and thin-layer chromatography analyses of phenolic compounds from rapeseed plants and evaluation of their antioxidant activity. Journal of Separation Science, 1-10. doi:10.1002/jssc.201800712
Rapeseed plants, known for oil production, are also known to contain phenolic compounds such as p...
Ielciu, I., Frederich, M., Hanganu, D., Angenot, L., Olah, N.-K., Ledoux, A., Crișan, G., & Păltinean, R. (2019). Flavonoid Analysis and Antioxidant Activities of the Bryonia alba L. Aerial Parts. Antioxidants, 8 (4 108). doi:10.3390/antiox8040108
Bryonia alba L. is the only Bryonia species found in Romanian flora, being known as a remedy for ...
Ielciu, I.-I., Mouithys-Mickalad, A., Franck, T., Angenot, L., Ledoux, A., Păltinean, R., Cieckiewicz, E., Etienne, D., Tits, M., Crişan, G., & Frederich, M. (2019). Flavonoid composition, cellular antioxidant activity and (myelo)peroxidase inhibition of a Bryonia alba L. (Cucurbitaceae) leaves extract. Journal of Pharmacy and Pharmacology, 71, 230-239. doi:10.1111/jphp.13025
Kowa, T. K., Tchokouaha, L. R. Y., Cieckiewicz, E., Philips, T. J., Dotse, E., Wabo, H. K., Tchinda, A. T., Tane, P., & Frederich, M. (2019). Antileishmanial and cytotoxic activities of a new limonoid and a new phenyl alkene from the stem bark of Trichilia gilgiana (Meliaceae). Natural Product Research, 0 (0), 1-7. doi:10.1080/14786419.2018.1553879
AbstractOne new limonoid, trigilgianin (1), one new phenyl alkene, epoxy gilgialkene (2), togethe...
Mahadeo, K., Herbette, G., Grondin, I., Jansen, O., Kodja, H., Soulange, J., Jhaumeer-Laulloo, S., Clerc, P., Gauvin-Bialecki, A., & Frederich, M. (2019). Antiplasmodial Diterpenoids from Psiadia arguta. Journal of Natural Products, 82 (5), 1261-1266. doi:10.1021/acs.jnatprod.8b00698
An ethyl acetate extract of Psiadia arguta leaves showed in vitro antiplasmodial activity against...
Mutwale Kapepula, P., Baku Ngumbi, P., Kasongo Kawayidiko, M., Duki Mpanzu, A., Franck, T., Mouithys-Mickalad, A., Frederich, M., Ngombe Kabamba, N., & Masiala Tsobo, C. (2019). Anti-inflammatory and antioxidant activities of Rungia congoensis, a traditional vegetable consumed by Yombe people from Kongo Central area (DR. Congo). Natural Product Research, 1-5. doi:10.1080/14786419.2018.1425847
Rungia congoensis, a traditional vegetable from Kongo Central area (DR. Congo) was studied for es...
Alson, S. G., Jansen, O., Cieckiewicz, E., Rakotoarimanana, H., Rafatro, H., Degotte, G., Francotte, P., & Frederich, M. (2018). In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives. Journal of Pharmacy and Pharmacology, 70 (10), 1349-1356. doi:10.1111/jphp.12982
OBJECTIVES: To explore the in-vitro and in-vivo antimalarial potential of caffeic acid and deriva...
Apel, C., Bignon, J., Garcia-Alvarez, M. C., Ciccone, S., Clerc, P., Grondin, I., Girard-Valenciennes, E., Smadja, J., Lopes, P., Frederich, M., Roussi, F., Meinnel, T., Giglione, C., & Litaudon, M. (2018). N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoe (L.) L. f. subsp. bentzoe. Fitoterapia, 131, 91-95. doi:10.1016/j.fitote.2018.10.014
N-myristoylation (Myr) is an eukaryotic N-terminal co- or post-translational protein modification...
Beaufays, C.* , Ledoux, A.* , Jansen, O., bordignon, A., Zhao, S., Teijaro, C., Andrade, R., Quetin-Leclercq, J., & Frederich, M. (2018). In vivo antimalarial and antitrypanosomal activity of strychnogucine B, a bisindole alkaloid from Strychnos icaja. Planta Medica, 84, 881-885. doi:10.1055/a-0644-2723
Strychnogucine B is a bisindole alkaloid previously isolated from Strychnos icaja that possesses ...
Campos, Pichon, E., Illien, B., Clerc, P., Moriou, C., de Voogd, N., Hellio, C., Trépos, R., Frederich, M., Al-mourabit, A., & Gauvin-Bialecki, A. (2018). (2S*,5S*,6Z)-2,5-Epoxydocosan-6-en-21-ynoic Acid, New Fatty Acid from the Marine Sponge Haliclona fascigera. Natural Products Chemistry and Research, 6 (5), 336. doi:10.4172/2329-6836.1000336
Douanla, P. D., Tchuendem, M. H. K., Tchinda, A. T., Kuiate, T., Zofou, D., Cieckiewicz, E., Frederich, M., & Nkengfack, A. E. (2018). Chemical Constituents of the Leaves of Caloncoba welwitschii Gilg. Phytochemistry Letters, 23 (October 2017), 5--8. doi:10.1016/J.PHYTOL.2017.10.019
Two new compounds namely acetylcaloncobaside (1) and friedocaloncobic acid (2) were isolated from...
Gbaweng, A. J. Y., Dairou, H., Zingue, S., Emmanuel, T., Tchinda, A. T., Frederich, M., & Mbafor, J. T. (2018). Excelsanone, a new isoflavonoid from Erythrina excelsa (Fabaceae), with in vitro antioxidant and in vitro cytotoxic effects on prostate cancer cells lines. Natural Product Research, 1-9. doi:10.1080/14786419.2018.1495639
A new isoflavonoid, excelsanone (2), was isolated from the ethyl acetate extract of Erythrina exc...
Ielciu, I., Hanganu, D., Ramona, P., Vlase, L., Frederich, M., Gheldiu, A.-M., Benedec, D., & Cri, G. (2018). Antioxidant capacity and polyphenolic content of the Echinocystis lobata (Michx.) Torr. et A.Gray flowers. Pakistan Journal of Pharmaceutical Sciences, 31 (2), 677-684.
Ledoux, A., Cao, M., Jansen, O., Coelho Cristino Mamede, L. C., Campos, P.-E., Payet, B., Clerc, P., Grondin, I., Girard-Valenciennes, E., Hermann, T., Litaudon, M., Vanderheydt, C., Delang, L., Neyts, J., Leyssen, P., Frederich, M., & Smadja, J. (2018). Antiplasmodial, Anti-chikungunya virus and Antioxidant Activities of 64 endemic Plants from the Mascarene Islands. International Journal of Antimicrobial Agents, 52 (5), 622-628. doi:10.1016/j.ijantimicag.2018.07.017
Vector-borne diseases cause more than 1 million deaths annually. The research of new medicines is...
Mahadeo, K., Grondin, I., Kodja, H., Soulange Govinden, J., Jhaumeer Laulloo, S., Frederich, M., & Gauvin-Bialecki, A. (2018). The genus Psiadia: Review of traditional uses, phytochemistry and pharmacology. Journal of Ethnopharmacology, 210, 48-68. doi:10.1016/j.jep.2017.08.023
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Psiadia Jacq. ex. Willd. belongs to the Asteraceae fami...
Saive, M., Frederich, M., & Fauconnier, M.-L. (2018). Plants used in traditional medicine and cosmetics in Mayotte Island (France): An ethnobotanical study. Indian Journal of Traditional Knowledge, 17 (4), 645-653.
Mayotte is a small island located in the Mozambique canal and due to this location it has long be...
Tomani, J. C. D., Gainkam, L. O. T., Nshutiyayesu, S., Mukazayire, M. J., Ribeiro, S. O., Stevigny, C., Frederich, M., Muganga, R., & Souopgui, J. (2018). An ethnobotanical survey and inhibitory effects on NLRP3 inflammasomes/Caspase-1 of herbal recipes' extracts traditionally used in Rwanda for asthma treatment. Journal of Ethnopharmacology, 227, 29-40. doi:10.1016/j.jep.2018.08.016
ETHNOPHARMACOLOGICAL RELEVANCE: Respiratory diseases and asthma, in particular, are nowadays a gl...
Katemo Muhoya, F., Kadima Ntokamunda, J., Njakarinala Ranarivelo, Frederich, M., Hubert, P., & Marini Djang'Eing'A, R. (11 September 2017). Preliminary Phytochemical Content and Antidiabetic Potential Investigations of Panda oleosa (Pierre) Used in Kisangani Areas. American Journal of Analytical Chemistry, 8, 564-581. doi:10.4236/ajac.2017.89041
Panda oleosa Pierre (POP), a tropical plant tree, has been used in traditional medicine in Kisang...
Bordignon, A., Frederich, M., Ledoux, A., Campos, P.-É., Clerc, P., Hermann, T., Quetin-Leclercq, J., & Cieckiewicz, E. (2017). In vitro antiplasmodial and cytotoxic activities of sesquiterpene lactones from Vernonia fimbrillifera Less. (Asteraceae). Natural Product Research, 1-4. doi:10.1080/14786419.2017.1350665
According to the World Health Organization (WHO 2016 WHO. 2016. World Malaria report 2016 [Intern...
Paul, A., Frederich, M., Caparros Megido, R., Alabi, T., Malik, P., Uyttenbroeck, R., Francis, F., Blecker, C., Haubruge, E., Lognay, G., & Danthine, S. (June 2017). Insect fatty acids: A comparison of lipids from three Orthopterans and Tenebrio molitor L. larvae. Journal of Asia-Pacific Entomology, 20 (2), 337-340. doi:10.1016/j.aspen.2017.02.001
In order to explore some potential insect sources of food lipids, the lipid compositions of three...
Ielciu, I.-I., Vlase, L., Frederich, M., Hanganu, D., Păltinean, R., Cieckiewicz, E., Olah, N.-K., Gheldiu, A.-M., & Crişan, G. (03 May 2017). Polyphenolic profile and biological activities of the leaves and aerial parts of Echinocystis lobata (Michx.) Torr. et A.Gray (Cucurbitaceae). Farmacia, 65 (2), 179-183.
The aim of the present study consisted in the quantification of the polyphenols in leaves and aer...
Campos, P.-E., Wolfender, J.-L., Quieroz, E. F., Marcourt, L., Al-Mourabit, A., Frederich, M., Bordignon, A., De Voogd, N., Illien, B., & Gauvin-Bialeki, A. (10 April 2017). Unguiculin A and Ptilomycalins E-H, Antimalarial Guanidine Alkaloids from the Marine Sponge Monanchora unguiculata. Journal of Natural Products, 80, 1404-1410. doi:10.1021/acs.jnatprod.6b01079
Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge Monanchora unguiculata collected ...
Issac, M., Aknin, M., Gauvin-Bialecki, A., De Voogd, N., Ledoux, A., Frederich, M., Kashman, Y., & Carmeli, S. (16 February 2017). Cyclotheonellazoles A–C, Potent Protease Inhibitors from the Marine Sponge Theonella aff. swinhoei. Journal of Natural Products, 80, 1110-1116. doi:10.1021/acs.jnatprod.7b00028
he extract of a sample of the sponge Theonella aff. swinhoei collected in Madagascar exhibited pr...
Bahati, L. M., Kapepula, P. M., Kabamba, N. N., Moni, B., Kafuti, G. M., Mungitshi, M., Pambu, A., Bongo, G., Mukuta, A. T., Kabengele, J. K., Mutunda, C. M., Frederich, M., & Fundu, T. M. (2017). Microscopic Features , Chromatographic Fingerprints and Antioxidant Property of Some Unconventional Green Leafy Vegetables Consumed in Bandundu , DR Congo. Pharmacognosy Communications, 7 (4), 158--163.
Dib, I., Tits, M., Angenot, L., Wauters, J. N., Assaidi, A., Mekhfi, H., Aziz, M., Bnouham, M., Legssyer, A., Frederich, M., & Ziyyat, A. (2017). Antihypertensive and vasorelaxant effects of aqueous extract of Artemisia campestris L. from Eastern Morocco. Journal of Ethnopharmacology, 206, 224-235. doi:10.1016/j.jep.2017.05.036
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia campestris L. (Asteraceae) has many traditional uses, a...
Ebralidze, L., Mskhiladze, L., Ledoux, A., Frederich, M., Bellahcene, A., Bero, J., Quetin-Leclercq, J., & Bakuridze, A. (2017). ANTICANCER, ANTIPLASMODIAL AND ANTITRYPANOSOMAL ACTIVITIES OF CRUDE EXTRACTS OF PLATANUS ORIENTALIS. World Journal of Pharmaceutical Research, 6 (3), 170-175. doi:10.20959/wjpr20173-7985
Govinden-Soulange, J., Lobine, D., Frederich, M., Kodja, H., Coetzee, M. P. A., & Ranghoo-Sanmukhiya, V. M. (2017). Metabolomic and molecular signatures of Mascarene Aloes using a multidisciplinary approach. South African Journal of Botany, 108, 137-143. doi:10.1016/j.sajb.2016.10.002
In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniquenes...
Jansen, O., Tchinda, A. T., Loua, J., Esters, V., Cieckiewicz, E., Ledoux, A., Toukam, P. D., Angenot, L., Tits, M., Balde, A. M., & Frederich, M. (2017). Antiplasmodial activity of Mezoneuron benthamianum leaves and identification of its active constituents. Journal of Ethnopharmacology, 203 (March), 20--26. doi:10.1016/j.jep.2017.03.021
Kapepula, P. M., Kabamba Ngombe, N., Tshisekedi Tshibangu, P., Tsumbu, C., Franck, T., Mouithys-Mickalad, A., Mumba, D., Tshala-Katumbay, D., Serteyn, D., Tits, M., Angenot, L., Kalenda, P. D. T., & Frederich, M. (2017). Comparison of metabolic profiles and bioactivities of the leaves of three edible Congolese Hibiscus species. Natural Product Research, 6419 (March), 1--8. doi:10.1080/14786419.2017.1305382
Ledoux, A., St-Gelais, A., Cieckiewicz, E., Jansen, O., Bordignon, A., Illien, B., Di Giovanni, N., Marvilliers, A., Hoareau, F., Pendeville-Samain, H., Leclercq, J., & Frederich, M. (2017). Antimalarial Activities of Alkyl Cyclohexenone Derivatives Isolated from the Leaves of Poupartia borbonica. Journal of Natural Products, 80 (6), 1750-1757. doi:10.1021/acs.jnatprod.6b01019
Bioactivity-guided fractionation of the ethyl acetate extract of the leaves of Poupartia borbonic...
Tshisekedi Tshibangu, P., Mutwale Kapepula, P., Kabongo Kapinga, M. J., Tujibikila Mukuta, A., Kalenda, D. T., Tchinda, A. T., Mouithys-Mickalad, A., Jansen, O., Cieckiewicz, E., Tits, M., Angenot, L., & Frederich, M. (2017). Antiplasmodial activity of Heinsia crinita (Rubiaceae) and identification of new iridoids. Journal of Ethnopharmacology, 196, 261-266. doi:10.1016/j.jep.2016.11.041
ETHNOPHARMACOLOGICAL RELEVANCE: Heinsia crinita is used in traditional medicine for the treatment...
Paul, A., Frederich, M., Uyttenbroeck, R., Malik, P., Filocco, S., Richel, A., Heuskin, S., Alabi, T., Caparros Megido, R., Franck, T., Bindelle, J., Maesen, P., Francis, F., Lognay, G., Blecker, C., Haubruge, E., & Danthine, S. (December 2016). Nutritional Composition and Rearing Potential of the Meadow Grasshopper (Chorthippus parallelus Zetterstedt). Journal of Asia-Pacific Entomology, 19 (4), 1111-1116. doi:10.1016/j.aspen.2016.09.012
Insects, particularly those belonging to the family Acrididae (grasshoppers), are commonly consum...
Mskhiladze, L., Chincharadze, D., St-Gelais, A., Mshvildadze, V., Pichette, A., Ledoux, A., Tits, M., & Frederich, M. (July 2016). Isolation and Identification of Steroid and Flavonoid Glycosides from the Flowers of Allium gramineum. International Journal of Pharmaceutical Sciences and Drug Research, 8 (4), 240-243.
The isolation and identification of β-sitosterol 3-O-β-glucopyranoside, quercetin 3-O-β-g...
Tshisekedi Tshibangu, P., Mutwale Kapepula, P., Kabongo Kapinga, M. J., Kabika Lupona, H., Kabamba Ngombe, N., Dibungi T. Kalenda, P., Jansen, O., Wauters, J.-N., Tits, M., Angenot, L., Rozet, E., Hubert, P., Marini Djang'Eing'A, R., & Frederich, M. (09 June 2016). Fingerprinting and validation of a LC-DAD method for the analysis of biflavanones in Garcinia kola-based antimalarial improved traditional medicines. Journal of Pharmaceutical and Biomedical Analysis, 128 (2016), 382-390. doi:10.1016/j.jpba.2016.04.042
African populations use traditional medicines in their initial attempt to treat a range of diseas...
Kengne, A. B. O., Tene, M., Tchinda Tiabou, A., Tane, P., & Frederich, M. (10 March 2016). Terpenoids from Phaulopsis imbricata (Acanthaceae). Journal of Medicinal Plant Research, 10 (10), 122-129.
The whole plant of Phaulopsis imbricata (Forssk.) Sweet (Acanthaceae) was collected at Bansoa, Ca...
Hamaïdia, M., Barez, P.-Y., Carpentier, A., Lebecque, S., Miazek, K., Paul, A., Neelature Sriramareddy, S., Staumont, B., Danthine, S., Deleu, M., Frederich, M., De Pauw, E., Delaplace, P., Delvigne, F., Goffin, D., Ongena, M., DUYSINX, B., LOUIS, R., cosse, J.-P., & Willems, L. (27 February 2016). From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound. Biotechnologie, Agronomie, Société et Environnement, 20 (S1), 314-320.
Over the centuries, bio-sourced compounds isolated from plants, insects and microorganisms have b...
Marquise, N., Chevallier, F., Nassar, E., Frederich, M., Ledoux, A., Halauko, Y. S., Ivashkevich, O. A., Matulis, V. E., Roisnel, T., Dorcet, V., & Mongin, F. (February 2016). Substituted azafluorenones: access from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes and evaluation of their antibacterial, antifungal, antimalarial and antiproliferative activities. Tetrahedron, 72 (6), 825-836. doi:10.1016/j.tet.2015.12.050
Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium cataly...
Frederich, M., Pirotte, B., Fillet, M., & De Tullio, P. (2016). Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine. Journal of Medicinal Chemistry, 59 (19), 8649–8666. doi:10.1021/acs.jmedchem.5b01335
"Omics" sciences have been developed to provide a holistic point of view of biology and to better...
Ielciu, I.-I., Frederich, M., Tits, M., Angenot, L., Paltinean, R., Cieckiewicz, E., Crisan, G., & Vlase, L. (2016). BRYONIA ALBA L. AND ECBALLIUM ELATERIUM (L.) A. RICH. - TWO RELATED SPECIES OF THE CUCURBITACEAE FAMILY WITH IMPORTANT PHARMACEUTICAL POTENTIAL. Farmacia, 64 (3), 323-332.
The importance of the Cucurbitaceae family consists not only in the species that are widely known...
Messi, A. N., Ngo Mbing, J., Ndongo, J. T., Nyegue, M. A., Tchinda, A. T., Yemeda, F. L., Frederich, M., & Pegnyemb, D. E. (2016). Phenolic compounds from the roots of Ochna schweinfurthiana and their antioxidant and antiplasmodial activities. Phytochemistry Letters, 17, 119-125. doi:10.1016/j.phytol.2016.07.011
An investigation of compounds extracted from Ochna schweinfurthiana roots with ethyl acetate led ...
Miazek, K., Lebecque, S., Hamaïdia, M., Paul, A., Danthine, S., Willems, L., Frederich, M., De Pauw, E., Deleu, M., Richel, A., & Goffin, D. (2016). Sphingolipids: Promising lipid-class molecules with potential applications for industry. A review. Biotechnologie, Agronomie, Société et Environnement, 20 (S1), 321-336.
Introduction. Sphingolipids are a group of lipid molecules, the focus on which has been gradually...
Mutwale Kapepula, P., Mbombo Mungitshi, P., Franck, T., Mouithys-Mickalad, A., Mumba Ngoyi, D., Kalenda, P. D. T., Kabamba Ngombe, N., Serteyn, D., Tits, M., Frederich, M., & Tamfum Muyembe, J.-J. (2016). Antioxidant potentiality of three herbal teas consumed in Bandundu rural areas of Congo. Natural Product Research, 1-4. doi:10.1080/14786419.2016.1263844
The aim of this study was to evaluate and compare the cellular antioxidant activities of Lantana ...
Paltinean, R., Toiu, A., Wauters, J.-N., Frederich, M., Tits, M., Angenot, L., Tamas, M., & Crisan, G. (2016). PHYTOCHEMICAL ANALYSIS OF FUMARIA OFFICINALIS L. (FUMARIACEAE). Farmacia, 64 (3), 409-413.
The present study describes the investigation of active compounds from several samples of Fumaria...
Paul, A., Frederich, M., Uyttenbroeck, R., Hatt, S., Malik, P., Lebecque, S., Hamaïdia, M., Miazek, K., Goffin, D., Willems, L., Deleu, M., Fauconnier, M.-L., Richel, A., De Pauw, E., Blecker, C., Monty, A., Francis, F., Haubruge, E., & Danthine, S. (2016). Grasshoppers as a food source? A review. Biotechnologie, Agronomie, Société et Environnement, 20 (AgricultureIsLife), 337-352.
Description of the subject. Current trends suggest an increasing future demand for conventional m...
Talla, E., Yaya Gbaweng, J., Mokale, L., Abdou, J.-P., Tchinda Tiabou, A., Frederich, M., & Mbafor, J. (2016). Chemical constituents from Erythrina droogmansiana (Fabaceae), radical scavenging and antibacterial potential of some extracts and compounds. Natural Products: An Indian Journal, 12 (1), 12-20.
A new ceramide, droogmansiamide (1), was isolated from methanolic extract of roots wood of Erythr...
Tshilanda, D. D., Mutwale Kapepula, P., Onyamboko, D. V. N., Frederich, M., Ngbolua, K.-T.-N., & Mpiana, P. T. (2016). Chemical Fingerprint and Anti-Sickling Activity of Rosmarinic Acid and Methanolic Extracts from Three Species of Ocimum from DR Congo. Journal of Biosciences and Medicines, 04 (January), 59--68. doi:10.4236/jbm.2016.41008
The aim of this study was to characterize the polyphenolic composition by determination of chemic...
Uyttenbroeck, R., Hatt, S., Paul, A., Boeraeve, F., Piqueray, J., Francis, F., Danthine, S., Frederich, M., Dufrêne, M., Bodson, B., & Monty, A. (2016). Pros and cons of flowers strips for farmers. A review. Biotechnologie, Agronomie, Société et Environnement, 20 (s1), 225-235.
Description of the subject. To counteract environmental problems due to agricultural intensificat...
Martin, B., Frederich, M., De Tullio, P., Tits, M., Wauters, J.-N., Choi, & Bodson, M. (June 2015). Metabolomics analysis of Galium odoratum (L.) Scop.: impact of the plant population origin and growth conditions. Current Metabolomics, 3.
Ledoux, A., Mareatefau, H., Jansen, O., Etienne, D., quetin-Leclercq, J., Clerc, P., Smadja, J., & Frederich, M. (April 2015). Phytochemical Profile and Biological Activity Evaluation of Zanthoxylum heterophyllum Leaves against Malaria. Planta Medica Letters, 2, 10-e11.
The aim of this study was to evaluate the antiplasmodial properties of Zanthoxylum heterophyllum,...
Cieckiewicz, E., Mathieu, V., Angenot, L., Gras, T., Dejaegher, B., De Tullio, P., Pirotte, B., & Frederich, M. (2015). Semisynthesis and in Vitro Photodynamic Activity Evaluations of Halogenated and Glycosylated Derivatives of Pheophorbide a. European Journal of Organic Chemistry, 2015 (27), 6061-6074. doi:10.1002/ejoc.201500387
The present work focuses on the semisynthesis of halogenated and glycosylated derivatives of pheo...
Douanla, P. D., Tabopda, T. K., Tchinda, A. T., Cieckiewicz, E., Frederich, M., Boyom, F. F., Tsabang, N., Yeboah, S., Nkengfack, A. E., & Tchuendem, M. H. K. (2015). Antrocarines A-F, antiplasmodial ergostane steroids from the stem bark of Antrocaryon klaineanum. Phytochemistry, 117, 521-6. doi:10.1016/j.phytochem.2015.07.011
During a study on the chemistry and biological activity of Antrocaryon klaineanum Pierre, six new...
Fillet, M., & Frederich, M. (2015). The emergence of metabolomics as a key discipline in the drug discovery process. Drug Discovery Today. Technologies, 13, 19-24. doi:10.1016/j.ddtec.2015.01.006
Gros, E., Martin, M.-T., Sorres, J., Moriou, C., Vacelet, J., Frederich, M., Aknin, M., Kashman, Y., Gauvin-Bialecki, A., & Al-Mourabit, A. (2015). Netamines O-S, Five New Tricyclic Guanidine Alkaloids from the Madagascar Sponge Biemna laboutei, and Their Antimalarial Activities. Chemistry and Biodiversity, 12 (11), 1725-33. doi:10.1002/cbdv.201400350
In our continuing program to isolate new compounds from the Madagascar sponge Biemna laboutei, fi...
Leenders, J., Frederich, M., & De Tullio, P. (2015). Nuclear magnetic resonance: a key metabolomics platform in the drug discovery process. Drug Discovery Today. Technologies, 13, 39-46. doi:10.1016/j.ddtec.2015.06.005
Metabolomics is an innovative tool that is now emerging in the drug discovery process. Indeed, it...
Leverrier, A., Bero, J., Cabrera, J., Frederich, M., Quetin-Leclercq, J., & Palermo, J. A. (2015). Structure-activity relationship of hybrids of Cinchona alkaloids and bile acids with in vitro antiplasmodial and antitrypanosomal activities. European Journal of Medicinal Chemistry, 100, 10-7. doi:10.1016/j.ejmech.2015.05.044
In this work, a series of hybrid compounds were tested as antiparasitic substances. These hybrids...
Mskhiladze, L., Chincharadze, D., Mshvildadze, V., Pichette, A., Frederich, M., Ollivier, E., & Elias, R. (2015). Steroidal Glycosides from the Flowers of Allium leucanthum. Chemistry of Natural Compounds, 51 (5), 900-904. doi:10.1007/s10600-015-1444-z
Furostanol and spirostanol glycosides 1 and 2 were isolated from the flowers of Allium leucanthum...
Mskhiladze, L., Chincharadze, D., Tits, M., Wauters, J.-N., Bellahcene, A., Castronovo, V., Mouithys-Mickalad, A., Franck, T., & Frederich, M. (2015). Identification of Cytotoxic and Antioxidant Compounds from Allium gramineum Flowers. International Journal of Pharmaceutical Sciences and Drug Research, 7, 78-82.
The present study evaluates the in vitro anticancer, antiplasmodial and antioxidant activity of t...
Paul, A., Frederich, M., Uyttenbroeck, R., Filocco, S., Hatt, S., Malik, P., Monty, A., Francis, F., Blecker, C., & Danthine, S. (2015). PROXIMATE ANALYSIS OF SEEDS FROM SOME FIELD BORDER FLOWERING STRIPS. Scientific Bulletin. Series F, Biotechnologies, XIX.
Field border flowering strips are commonly grown throughout the world mainly to enhance biodivers...
Sauri, J., Frederich, M., Tchinda, A. T., Parella, T., Williamson, R. T., & Martin, G. E. (2015). Carbon Multiplicity Editing in Long-Range Heteronuclear Correlation NMR Experiments: A Valuable Tool for the Structure Elucidation of Natural Products. Journal of Natural Products, 78 (9), 2236-41. doi:10.1021/acs.jnatprod.5b00447
A recently developed NMR method to simultaneously obtain both long-range heteronuclear correlatio...
Tchinda, A. T., Mouokeu, S. R., Ngono, R. A. N., Ebelle, M. R. E., Mokale, A. L. K., Nono, D. K., & Frederich, M. (2015). A new ent-clerodane diterpenoid from Crassocephalum bauchiense Huch. (Asteraceae). Natural Product Research, 29 (21), 1990-1994. doi:10.1080/14786419.2015.1022541
A phytochemical investigation of the whole plant of Crassocephalum bauchiense Huch. resulted in t...
Tchinda Tiabou, A., Tsala, D. E., Nnanga, N., Cieckiewicz, E., Kiss, R., Connolly, J. D., & Frederich, M. (November 2014). Two new aromadendrane sesquiterpenes from the stem bark of Alafia multiflora. Natural Product Communications, 9 (12), 1673-1675. doi:10.1177/1934578x1400901202
Gros, E., Al-Mourabit, A., Martin, M.-T., Sorres, J., Vacelet, J., Frederich, M., Aknin, M., Kashman, Y., & Gauvin-Bialecki, A. (April 2014). Netamines H-N, Tricyclic Alkaloids from the Marine Sponge Biemna laboutei and Their Antimalarial Activity. Journal of Natural Products, 77 (4), 818-23. doi:10.1021/np4009283
Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei re...
Kopa, T. K., Tchinda Tiabou, A., Tala, M. F., Zofou, D., Jumbam, R., Wabo, H. K., Titanji, V. P. K., Frederich, M., Tan, N. H., & Tane, P. (January 2014). Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae). Phytochemistry Letters, 8, 41-45. doi:10.1016/j.phytol.2014.01.010
Chemical investigation of the methanol extract of the leaves of Tectona grandis led to the isolat...
Kpadonou Kpoviessi, B. G. H., Kpoviessi, S. D. S., Yayi Ladekan, E., Gbaguidi, F., Frederich, M., Moudachirou, M., Quetin-Leclercq, J., Accrombessi, G. C., & Bero, J. (2014). In vitro antitrypanosomal and antiplasmodial activities of crude extracts and essential oils of Ocimum gratissimum Linn from Benin and influence of vegetative stage. Journal of Ethnopharmacology, 155 (3), 1417-23. doi:10.1016/j.jep.2014.07.014
ETHNOPHARMACOLOGICAL RELEVANCE: Different parts of Ocimum gratissimum Linn are largely used in fo...
Kpoviessi, S., Bero, J., Agbani, P., Gbaguidi, F., Kpadonou-Kpoviessi, B., Sinsin, B., Accrombessi, G., Frederich, M., Moudachirou, M., & Quetin-Leclercq, J. (2014). Chemical composition, cytotoxicity and in vitro antitrypanosomal and antiplasmodial activity of the essential oils of four Cymbopogon species from Benin. Journal of Ethnopharmacology, 151, 652-659. doi:10.1016/j.jep.2013.11.027
ETHNOPHARMACOLOGICAL RELEVANCE: Cymbopogon species are largely used in folk medicine for the trea...
Matheus, N., Hansen, S., Rozet, E., Peixoto, P., Maquoi, E., LAMBERT, V., Noël, A., Frederich, M., Mottet, D., & De Tullio, P. (January 2014). An Easy, Convenient Cell and Tissue Extraction Protocol for Nuclear Magnetic Resonance Metabolomics. Phytochemical Analysis, 25, 342-349. doi:10.1002/pca.2498
INTRODUCTION: As a complement to the classic metabolomics biofluid studies, the visualisation of ...
Muganga, R., Angenot, L., Tits, M., & Frederich, M. (2014). In Vitro and In Vivo Antiplasmodial Activity of Three Rwandan Medicinal Plants and Identification of Their Active Compounds. Planta Medica, 80 (6), 482-489. doi:10.1055/s-0034-1368322
In our previous study, we reported the interesting in vitro antiplasmodial activity of some Rwand...
Perera Cordoba, W. H., Wauters, J.-N., Kevers, C., Frederich, M., & Dommes, J. (2014). Antioxidant fractions and phenolic constituents from leaves of Pluchea carolinensis and Pluchea rosea. Free Radicals and Antioxidants, 4 (2), 1-7. doi:10.5530/fra.2014.2.1
Abstract: Objective: To evaluated the antioxidant potential of several polar fractions of P. car...
Tchinda Tiabou, A., Agbor, G., Tsala, D., Yaya, A., Nga, E., Talla, E., Wauters, J.-N., & Frederich, M. (2014). Antioxidant Activity of Flavonoids Isolated From the Fruits of Xylopia parviflora (A. Rich.) Benth. International Journal of Pharmaceutical Sciences and Drug Research, 6, 253-258.
Tchinda Tiabou, A., Jansen, O., Nyemb, J.-N., Tits, M., Dive, G., Angenot, L., & Frederich, M. (2014). Strychnobaillonine, an Unsymmetrical Bisindole Alkaloid with an Unprecedented Skeleton from Strychnos icaja Baill. Roots. Journal of Natural Products, 77, 1078-1082.
Yaya, A., Feumba, R., Emmanuel, T., Tchinda Tiabou, A., Frederich, M., Oben, J., & Mbafor, J. (2014). Antioxidant Activity of Compounds Isolated from the Root Woods of Erythrina droogmansiana. International Journal of Pharmaceutical Sciences and Drug Research, 6 (2), 160-163.
The aim of this study was to isolate, to characterize secondary metabolites from methanolic extra...
zidane, A., Tits, M., Angenot, L., Wauters, J.-N., Frederich, M., Dib, I., Mekhfi, H., Aziz, M., Bnouham, M., Abdelkhaleq, L., & Ziyyat, A. (2014). Phytochemical analysis of Tetraclinis articula in relation to its vasorelaxant property. Journal of Materials and Environmental Science, 5 (5), 1368-1375.
Tetraclinis articulata (Cupressaceae), a traditional Moroccan herbal drug is used in oriental Mor...
Denooz, R., VAN HEUGEN, J.-C., Frederich, M., De Tullio, P.* , & Charlier, C.*. (March 2013). Identification and structure elucidation of four cannabimimetic compounds in seized products. Journal of Analytical Toxicology, 37 (2), 56-63. doi:10.1093/jat/bks095
Since 2008, herbal mixtures with synthetic cannabinoid compounds have been sold as incense throug...
Esters, V., Karangwa, C., Tits, M., Francotte, P., Pirotte, B., Servais, A.-C., Fillet, M., Crommen, J., Robbrecht, E., MINET, A., Grisar, T., Angenot, L., & Frederich, M. (March 2013). Unusual Amino Acids and Monofluoroacetate from Dichapetalum michelsonii (Umutambasha), a Toxic Plant from Rwanda. Planta Medica, 79, 334-337. doi:10.1055/s-0032-1328283
In the course of our investigations on Umutambasha in order to identify its convulsant principles...
Bero, J., Herent, M.-F., Schmeda-Hirschmann, G., Frederich, M., & Quetin-Leclercq, J. (2013). In vivo antimalarial activity of Keetia leucantha twigs extracts and in vitro antiplasmodial effect of their constituents. Journal of Ethnopharmacology, 149 (1), 176-83. doi:10.1016/j.jep.2013.06.018
ETHNOPHARMACOLOGICAL RELEVANCE: The West African tree Keetia leucantha (Rubiaceae) is used in tra...
Bournine, L., Bensalem, S., Peixoto, P., Gonzalez, A., Maiza-Benabdesselam, F., Bedjou, F., Wauters, J.-N., Tits, M., Frederich, M., Castronovo, V., & Bellahcene, A. (2013). Revealing the anti-tumoral effect of Algerian Glaucium flavum roots against human cancer cells. Phytomedicine, 20 (13), 1211-1218. doi:10.1016/j.phymed.2013.06.007
Glaucium flavum (G. flavum) is a plant from the Papaveraceae family native to Algeria where it is...
bournine, L., Bensalem, S., Wauters, J.-N., Iguer-Ouada, M., Maiza-Benabdesselam, F., Bedjou, F., Castronovo, V., Bellahcene, A., Tits, M., & Frederich, M. (2013). Identification and Quantification of the Main Active Anticancer Alkaloids from the Root of Glaucium flavum. International Journal of Molecular Sciences, 14, 23533-23544. doi:10.3390/ijms141223533
Glaucium flavum is used in Algerian folk medicine to remove warts (benign tumors). Its local appe...
Harnafi, H., Ramchoun, M., Tits, M., Wauters, J.-N., Frederich, M., Angenot, L., Aziz, M., Alem, C., & Amrani, S. (2013). Phenolic acid-rich extract of sweet basil restores cholesterol and triglycerides metabolism in high fat diet-fed mice: A comparison with fenofibrate. Biomedicine and Preventive Nutrition, 3 (4), 393-397. doi:10.1016/j.bionut.2013.03.005
Many spices are often added to foods as additives to enhance organoleptic qualities, such as flav...
Jonville, M.-C., Dive, G., Angenot, L., Bero, J., Tits, M., Ollivier, E., & Frederich, M. (2013). Dimeric bisindole alkaloids from the stem bark of Strychnos nux-vomica L. Phytochemistry, 87, 157-163. doi:10.1016/j.phytochem.2012.11.002
Strychnos nux-vomica L. (Loganiaceae) is famous for its monomeric alkaloid content, such as stryc...
Leverrier, A., Bero, J., Frederich, M., Quetin-Leclercq, J., & Palermo, J. (2013). Antiparasitic hybrids of Cinchona alkaloids and bile acids. European Journal of Medicinal Chemistry, 66, 355-63. doi:10.1016/j.ejmech.2013.06.004
A series of 16 hybrids of Cinchona alkaloids and bile acids (4a-h, 5a-h) was prepared by means of...
Mangwala Kimpende, P., Lusakibanza, M., Mesia, K., Tona, L., Tits, M., Angenot, L., Frederich, M., & Van Meervelt, L. (2013). Isolation, pharmacological activity and structure determination of physalin B and 5[beta],6[beta]-ep­oxy­physalin B isolated from Congolese Physalis angulata L. Acta Crystallographica. Section C, Structural Chemistry, C69, 1557-1562. doi:10.1107/S010827011303117X
Physalis angulata L., an annual herb from the Solanaceae family, is widely used in popular medici...
Mouton, J., Jansen, O., Frederich, M., & van der Kooy, F. (2013). Is artemisinin the only antiplasmodial compound in the Artemisia annua tea infusion? An in vitro study. Planta Medica, 79 (6), 468-70. doi:10.1055/s-0032-1328324
In our ongoing investigation into Artemisia annua for the treatment of malaria, we decided to stu...
Paltinean, R., Toju, A., Wauters, J.-N., Frederich, M., Tits, M., Angenot, L., Tamas, M., & Crisan, G. (2013). Identification and determination of alkaloids in Fumaria Species from Romania. Digest Journal of Nanomaterials and Biostructures, 8 (2), 817-824.
Four Fumaria species (F. vaillantii Loisel, F. parviflora Lam., F. rostellata Knaf and F. jankae ...
Paltinean, R., Wauters, J.-N., Tits, M., Frederich, M., Angenot, L., Mircea, T., & Crisan, G. (2013). Comparative morphological studies on some species of the genus Fumaria. Farmacia, 61 (2), 371-377.
Cieckiewicz, E., Angenot, L., Gras, T., Kiss, R., & Frederich, M. (15 February 2012). Potential anticancer activity of young Carpinus betulus leaves. Phytomedicine, 19 (3/4), 278-284. doi:10.1016/j.phymed.2011.09.072
As part of our continuing research for anticancer compounds from the Walloon Region forest, EtOAc...
Cao, M., Muganga, R., Nistor, I., Tits, M., Angenot, L., & Frederich, M. (2012). LC–SPE–NMR–MS analysis of Strychnos usambarensis fruits from Rwanda. Phytochemistry Letters, 5 (0), 170-173. doi:10.1016/j.phytol.2011.12.003
The novelty of the present work lies in the characterization of akagerine and palicoside in Stryc...
Ganfon, Bero, J., Tchinda Tiabou, A., Gbaguidi, F., Gbenou, J., Moudachirou, M., Frederich, M., & Quetin-Leclercq", J. (2012). Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum hispidum D.C. Journal of Ethnopharmacology, 141 (0), 411-417. doi:10.1016/j.jep.2012.03.002
Ethnopharmacological relevance : Aerial parts of Acanthospermum hispidum D.C. are often used by t...
Jansen, O., Tits, M., Angenot, L., Nicolas, J.-P., De Mol, P., Nikiema, J.-B., & Frederich, M. (2012). Anti-plasmodial activity of Dicoma tomentosa (Asteraceae) and identification of urospermal A-15- O-acetate as the main active compound. Malaria Journal, 11 (1), 289 (1-9. doi:10.1186/1475-2875-11-289
ABSTRACT: BACKGROUND: Natural products could play an important role in the challenge to discover ...
Kalume, Losson, B., Angenot, L., Tits, M., Wauters, J.-N., Frederich, M., & Saegerman, C. (2012). Rotenoid content and in vitro acaricidal activity of Tephrosia vogelii leaf extract on the tick Rhipicephalus appendiculatus. Veterinary Parasitology, 190 (1-2), 204-209. doi:10.1016/j.vetpar.2012.06.015
Ndontsa, B., Tchinda Tiabou, A., Teponno, R., Mpetga, J., Frederich, M., & Tane, P. (2012). Ardisikivuoside, a new triterpenoid saponin from Ardisia kivuensis (Mysinaceae). Natural Product Communications, 7.
Servais, A.-C., Rousseau, A., Dive, G., Frederich, M., Crommen, J., & Fillet, M. (2012). Combination of capillary electrophoresis, molecular modelling and nuclear magnetic resonance to study the interaction mechanisms between single-isomer anionic cyclodextrin derivatives and basic drug enantiomers in a methanolic background electrolyte. Journal of Chromatography. A, 1232, 59-64. doi:10.1016/j.chroma.2011.10.010
In order to improve our knowledge of the mechanisms of enantiomer recognition pattern in nonaqueo...
Tchinda Tiabou, A., Ngono, A. R., Tamze, V., Jonville, M., Cao, M., Angenot, L., & Frederich, M. (2012). Antiplasmodial Alkaloids from the Stem Bark of Strychnos malacoclados. Planta Medica, 78, 377-382. doi:10.1055/s-0031-1280473
From the stem bark of STRYCHNOS MALACOCLADOS, one new bisindole alkaloid, 3-hydroxylongicaudatine...
Tchinda Tiabou, A., Tamze, V., Ngono, A. R. N., Ayimele, G. A., Cao, M., Angenot, L., & Frederich, M. (2012). Alkaloids from the stem bark of Strychnos icaja. Phytochemistry Letters, 5 (1), 108-113. doi:10.1016/j.phytol.2011.11.004
A comprehensive phytochemical study of the stem bark of Strychnos icaja was done for the first ti...
Tsumbu, C. N., Dupont, G., Tits, M., Angenot, L., Frederich, M., Kohnen, S., Mouithys-Mickalad, A., Serteyn, D., & Franck, T. (2012). Polyphenol Content and Modulatory Activities of Some Tropical Dietary Plant Extracts on the Oxidant Activities of Neutrophils and Myeloperoxidase. International Journal of Molecular Sciences, 13 (1), 628-650. doi:10.3390/ijms13010628
Wabo, H. K., Kowa, T. K., Lonfouo, A. H., Tchinda Tiabou, A., Tane, P., Kikuchi, H., Frederich, M., & Oshima, Y. (2012). Phenolic Compounds and Terpenoids from Hypericum lanceolatum. Records of Natural Products, 6 (2), 94-100.
Zime Diawara, H., Dive, G., Piel, G., Moudachirou, M., Quetin-Leclercq, J., Frederich, M., & Evrard, B. (2012). UNDERSTANDING THE INTERACTIONS BETWEEN ARTEMISININ AND CYCLODEXTRINS: SPECTROSCOPIC STUDIES AND MOLECULAR MODELING. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 74 (1), 305-315. doi:10.1007/s10847-012-0117-9
Cao, M., Muganga, R., Tits, M., Angenot, L., & Frederich, M. (August 2011). 17-O-Acetyl,10-hydroxycorynantheol, a Selective Antiplasmodial Alkaloid Isolated from Strychnos usambarensis Leaves. Planta Medica, 77, 2050-2053. doi:10.1055/s-0031-1280124
In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostryc...
Frederich, M., Wauters, J.-N., Tits, M., Jason, C., De Tullio, P., Van der Heyden, Y., Fan, G., & Angenot, L. (2011). Quality Assessment of Polygonum cuspidatum and Polygonum multiflorum by 1H NMR Metabolite Fingerprinting and Profiling Analysis. Planta Medica, 77, 81-86. doi:10.1055/s-0030-1250132
The quality assessment and control of traditional Chinese medicines (TCM) nowadays receives a gre...
Jonville, M., Kodja, H., Strasberg, D., Pichette, A., Ollivier, E., Frederich, M., Angenot, L., & Legault, J. (2011). Antiplasmodial, anti-inflammatory and cytotoxic activities of various plant extracts from the Mascarene Archipelago. Journal of Ethnopharmacology, 136, 525-531. doi:10.1016/j.jep.2010.06.013
AIM OF THE STUDY: Antiplasmodial activity, inhibition of nitric oxide (NO) overproduction, and an...
Nistor, I., Cao, M., Debrus, B., Lebrun, P., Lecomte, F., Rozet, E., Angenot, L., Frederich, M., Oprean, R., & Hubert, P. (2011). Application of a new optimization strategy for the separation of tertiary alkaloids extracted from Strychnos usambarensis leaves. Journal of Pharmaceutical and Biomedical Analysis, 56, 30-37. doi:10.1016/j.jpba.2011.04.027
The HPLC separation of six alkaloids extracted from Strychnos usambarensis leaves has been develo...
Tistaert, C., Thierry, L., Szandrach, A., Dejaegher, B., Fan, G., Frederich, M., & Vander Heyden, Y. (2011). Quality control of Citri reticulatae pericarpium: Exploratory analysis and discrimination. Analytica Chimica Acta, 705 (1-2), 111-22. doi:10.1016/j.aca.2011.04.024
Extracts of Citri reticulatae pericarpium (PCR) are commonly used in the Traditional Chinese Medi...
Balde, E.-H. S., Mégalizzi, V., Angenot, L., Cao, M., Kiss, R., Van Damme, M., & Frederich, M. (2010). Isostrychnopentamine, an Indolomonoterpenic Alkaloid from Strychnos usambarensis, with Potential Antitumor Activity against Apoptosis-Resistant Cancer Cells. International Journal of Oncology, 36, 961-965. doi:10.3892/ijo_00000575
Castagne, D., Dive, G., Evrard, B., Frederich, M., & Piel, G. (2010). Spectroscopic studies and molecular modeling for understanding the interactions between cholesterol and cyclodextrins. Journal of Pharmacy and Pharmaceutical Sciences, 13 (2), 362-377. doi:10.18433/j3bs34
Frederich, M., Jansen, C., De Tullio, P., Tits, M., Demoulin, V., & Angenot, L. (2010). Metabolomic analysis of Echinacea spp. by (1)H nuclear magnetic resonance spectrometry and multivariate data analysis technique. Phytochemical Analysis, 21 (1), 61-65. doi:10.1002/pca.1156
Introduction - The genus Echinacea (Asteraceae) comprises about 10 species originally distributed...
Gillotin, F., Chiap, P., Frederich, M., Van Heugen, J.-C., Francotte, P., Lebrun, P., Pirotte, B., & De Tullio, P. (2010). Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 38 (2), 232-240. doi:10.1124/dmd.109.028928
SUR1-selective ATP-sensitive potassium channel openers (PCOs) have been shown to be of clinical v...
Jansen, O., Angenot, L., Tits, M., Nicolas, J. P., De Mol, P., Nikiéma, J. B., & Frederich, M. (2010). Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties. Journal of Ethnopharmacology, 130, 143-150. doi:10.1016/j.jep.2010.04.032
AIM OF THE STUDY: The aim of this study was to evaluate the antiplasmodial properties of 13 plant...
Liu, N. Q., Cao, M., Frederich, M., Choi, Y. H., Verpoorte, R., & van der Kooy, F. (2010). Metabolomic investigation of the ethnopharmacological use of Artemisia afra with NMR Spectroscopy and Multivariate Data Analysis. Journal of Ethnopharmacology, 128, 230-235. doi:10.1016/j.jep.2010.01.020
Ethnopharmacological relevance: Artemisia afra has been used as an infusion to treat malaria thro...
Lusakibanza, M., Mesia, G., Tona, G., Karemere, S., Lukuka, A., Tits, M., Angenot, L., & Frederich, M. (2010). In vitro and in vivo antimalarial and cytotoxic activity of five plants used in Congolese traditional medicine. Journal of Ethnopharmacology, 129, 398-402. doi:10.1016/j.jep.2010.04.007
AIM OF THE STUDY: The in vitro antiplasmodial activity and cytotoxicity of methanolic and dichlor...
Muganga, R., Angenot, L., Tits, M., & Frederich, M. (2010). Antiplasmodial and cytotoxic activities of Rwandan medicinal plants used in the treatment of malaria. Journal of Ethnopharmacology, 128, 52-55. doi:10.1016/j.jep.2009.12.023
AIM OF THE STUDY: In our study, methanol, dichloromethane and aqueous extracts of 13 Rwandan medi...
Ranghoo-Sanmukhiya, M., Govinden-Soulange, J., Lavergne, C., Khoyratty, S., Da Silva, D., Frederich, M., & Kodja, H. (2010). Molecular biology, phytochemistry and bioactivity of three endemic Aloe species from Mauritius and Reunion Islands. Phytochemical Analysis. doi:10.1002/pca.1234
Introduction - Aloe tormentorii, A. purpurea and A. macra are used as multipurpose folk medicines...
Verpoorte, R., Frederich, M., Delaude, C., Angenot, L., Dive, G., Thépenier, P., Jacquier, M.-J., Zèches-Hanrot, M., Lavaud, C., & Nuzillard, J.-M. (2010). Moandaensine, a dimeric indole alkaloid from Strychnos moandaensis (Loganiaceae). Phytochemistry Letters, 3, 100-103. doi:10.1016/j.phytol.2010.02.005
Moandaensine contains a rare anhydronium base subunit. It presents a moderate antiplasmodial acti...
Ouattara, B., Jansen, O., Angenot, L., Guissou, P., Frederich, M., Fondu, P., & Tits, M. (March 2009). Antisickling properties of divanilloylquinic acids isolated from Fagara zanthoxyloides Lam. (Rutaceae). Phytomedicine, 16 (2-3), 125-129. doi:10.1016/j.phymed.2008.10.013
Fagara zanthoxyloides Lam. (syn. Zanthoxylum zanthoxyloides) (Rutaceae) is the most cited Fagara ...
Bero, J., Frederich, M., & Quetin-Leclercq, J. (2009). Antimalarial compounds isolated from plants used in traditional medicine. Journal of Pharmacy and Pharmacology, 61 (11), 1401-33. doi:10.1211/jpp.61.11.0001
OBJECTIVES: This review covers the compounds with antiplasmodial activity isolated from plants pu...
Bero, J., Ganfon, H., Jonville, M., Frederich, M., Gbaguidi, F., De Mol, P., Moudachirou, M., & Quetin-Leclercq, J. (2009). In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria. Journal of Ethnopharmacology, 122, 439-444. doi:10.1016/j.jep.2009.02.004
Aim of the study: The aim of the studywas to evaluate the in vitro antiplasmodial activity of cru...
Frederich, M., Delvaux, D., Gigliobianco, T., GANGOLF, M., Dive, G., Mazzucchelli, G., Elias, B., De Pauw, E., Angenot, L., Wins, P., & Bettendorff, L. (2009). Thiaminylated adenine nucleotides — chemical synthesis, structural characterization and natural occurrence. FEBS Journal, 276 (12), 3256–3268. doi:10.1111/j.1742-4658.2009.07040.x
Thiamine and its three phosphorylated derivatives (mono-, di- and triphosphate) occur naturally i...
Frederich, M., Marcowycz, A., Cieckiewicz, E., Megalizzi, V., Angenot, L., & Kiss, R. (2009). In Vitro Anticancer Potential of Tree Extracts from the Walloon Region Forest. Planta Medica, 75 (15), 1634-1637. doi:10.1055/s-0029-1185867
Forty-eight extracts from 16 common Belgian trees from the Walloon Region forest were evaluated f...
Karangwa, C., Esters, V., Frederich, M., Tits, M., Kadima, J. N., Damas, J., Noirfalise, A., & Angenot, L. (2009). Erratum to “Chemical and biological investigations of a toxic plant from Central Africa, Magnistipula butayei subsp. montana” [J. Ethnopharmacol. 103 (2006) 433–438]. Journal of Ethnopharmacology, 125, 503. doi:10.1016/j.jep.2009.06.035
Murebwayire, S., Ingkaninan, K., Changwijit, K., Frederich, M., & Duez, P. (2009). Triclisia sacleuxii (Pierre) Diels (Menispermaceae), a potential source of acetylcholinesterase inhibitors. Journal of Pharmacy and Pharmacology, 61 (1), 103-7. doi:10.1211/jpp/61.01.0014
OBJECTIVES: To search for compounds possibly useful for the treatment of Alzheimer's disease. MET...
Jonville, M., Capel, M., Frederich, M., Angenot, L., Dive, G., Faure, R., Azas, N., & Ollivier, E. (November 2008). Fagraldehyde, a Secoiridoid Isolated from Fagraea fragrans. Journal of Natural Products, 71 (12), 2038-2040. doi:10.1021/np800291d
A secoiridoid aglycone with atypical skeleton, named fagraldehyde (1), together with several know...
Jansen, O., Frederich, M., Tits, M., Angenot, L., Cousineau, S., Bessot, L., Crunet, C., & Nicolas, J.-P. (July 2008). Ethnopharmacologie et paludisme au Burkina Faso : sélection de 13 espèces à potentialités antiplasmodiales méconnues. Ethnopharmacologia, 41, 74-81.
Dans la recherche de nouvelles substances actives contre les Plasmodium, les flores non explorées...
Barillaro, V., Dive, G., Bertholet, P., Evrard, B., Delattre, L., Frederich, M., Ziemons, E., & Piel, G. (22 January 2008). Theoretical and Experimental Investigations of Organic Acids/Cyclodextrin Complexes and Their Consequences Upon the Formation of Miconazole/Cyclodextrin/Acid Ternary Inclusion Complexes. International Journal of Pharmaceutics, 347 (1-2), 62-70. doi:10.1016/j.ijpharm.2007.06.030
(1)H NMR spectrometry, FT-IR spectroscopy, as well as molecular modeling at the AM1 level and nor...
Frederich, M., Tits, M., & Angenot, L. (January 2008). Potential antimalarial activity of indole alkaloids. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102 (1), 11-19. doi:10.1016/j.trstmh.2007.10.002
New antimalarial treatments are now urgently required, following the emergence of resistance to t...
Jonville, M., Kodja, H., Humeau, L., Fournel, J., De Mol, P., Cao, M., Angenot, L., & Frederich, M. (2008). Screening of medicinal plants from Reunion Island for antimalarial and cytotoxic activity. Journal of Ethnopharmacology, 120 (3), 382-6. doi:10.1016/j.jep.2008.09.005
AIM OF THE STUDY: Nine plants from Reunion Island, selected using ethnopharmacology and chemotaxo...
Murebwayire, S., Frederich, M., Hannaert, V., Jonville, M., & Duez, P. (2008). Antiplasmodial and antitrypanosomal activity of Triclisia sacleuxii (Pierre) Diels. Phytomedicine, 15 (9), 728-733. doi:10.1016/j.phymed.2007.10.005
The antiplasmodial and antitrypanosomal activities of Triclisia sacleuxii (Pierre) Diels were inv...
Jokhadze, M., Eristavi, L., Kutchukhidze, J., Chariot, A., Angenot, L., Tits, M., Jansen, O., & Frederich, M. (July 2007). In vitro cytotoxicity of some medicinal plants from Georgian amaryllidaceae. Phytotherapy Research, 21 (7), 622-624. doi:10.1002/ptr.2130
Using an ethnomedical data approach, some Georgian plants, which are used in Georgian traditional...
Philippe, G., De Mol, P., Angenot, L., Tits, M., & Frederich, M. (May 2007). In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja. Planta Medica, 73 (5), 478-479. doi:10.1055/s-2007-967174
Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of ...
Ziemons, E., Dive, G., Debrus, B., Barillaro, V., Frederich, M., Lejeune, R., Angenot, L., Delattre, L., Thunus, L., & Hubert, P. (February 2007). Study of the physicochemical properties in aqueous medium and molecular modeling of tagitinin C/cyclodextrin complexes. Journal of Pharmaceutical and Biomedical Analysis, 43 (3), 910-919. doi:10.1016/j.jpba.2006.09.011
The inclusion complexes of tagitinin C with beta-, 2,6-di-O-methyl-beta- and gamma-cyclodextrin (...
Bettendorff, L., Wirtzfeld, B., Makarchikov, A. F., Mazzucchelli, G., Frederich, M., Gigliobianco, T., Gangolf, M., De Pauw, E., Angenot, L., & Wins, P. (2007). Discovery of a natural thiamine adenine nucleotide. Nature Chemical Biology, 3 (4), 211-212. doi:10.1038/nchembio867
Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here,...
Frederich, M., Philippe, G., Tits, M., & Angenot, L. (2007). Potentialités antipaludiques des alcaloïdes indoliques. Actualités de Chimie Thérapeutique, 33, 1-32.
This paper will be mainly illustrated with references to selected antiplasmodial compounds:- indo...
Gnoula, C., Guissou, P., Duez, P., Frederich, M., & Dubois, J. (2007). Nematocidal compounds from the seeds of Balanites aegyptiaca isolation and structure elucidation. International Journal of Pharmacology, 3 (3), 280-284. doi:10.3923/ijp.2007.280.284
A study was conducted to characterize the anthelmintic activity and to isolate the main nematocid...
Esters, V., Angenot, L., Brandt, V., Frederich, M., Tits, M., Van Nerum, C., Wauters, J.-N., & Hubert, P. (21 April 2006). Validation of a high-performance thin-layer chromatography/densitometry method for the quantitative determination of glucosamine in a herbal dietary supplement. Journal of Chromatography. A, 1112 (1-2), 156-164. doi:10.1016/j.chroma.2006.01.035
A quantitative densitometric high-performance thin-layer chromatography (HPTLC) method was develo...
Jansen, O., Akhmedjanova, V., Angenot, L., Balansard, G., Chariot, A., Ollivier, E., Tits, M., & Frederich, M. (21 April 2006). Screening of 14 alkaloids isolated from Haplophyllum A. Juss. for their cytotoxic properties. Journal of Ethnopharmacology, 105 (1-2), 241-245. doi:10.1016/j.jep.2005.11.001
Further to a systematic chemotaxonomic study of Uzbek Haplophyllum A. Juss. plants selected on et...
Kenmogne, M., Prost, E., Harakat, D., Jacquier, M.-J., Frederich, M., Sondengam, L. B., Zèches, M., & Waffo-Téguo, P. (March 2006). Five labdane diterpenoids from the seeds of Aframomum zambesiacum. Phytochemistry, 67 (5), 433-438. doi:10.1016/j.phytochem.2005.10.015
Five labdane diterpenoids, (3-5), zambesiacolactone A (7) and zambesiacolactone B (8), were isola...
Karangwa, C., Esters, V., Frederich, M., Tits, M., Kadima, J. N., Damas, J., Noirfalise, A., & Angenot, L. (February 2006). Chemical and biological investigations of a toxic plant from Central Africa, Magnistipula butayei subsp montana. Journal of Ethnopharmacology, 103 (3), 433-438. doi:10.1016/j.jep.2005.08.019
Magnistipida butayei subsp. montana (Chrysobalanaceae) is known, in the Great Lakes Region, to po...
Philippe, G., Nguyen, L., Angenot, L., Frederich, M., Moonen, G., Tits, M., & Rigo, J.-M. (13 January 2006). Study of the interaction of antiplasmodial strychnine derivatives with the glycine receptor. European Journal of Pharmacology, 530 (1-2), 15-22. doi:10.1016/j.ejphar.2005.11.048
Strychnos icaja Baill. (Loganiaccae) is a liana found in Central Africa known to be an arrow and ...
Jokhadze, M., Kutchukhidze, J., Murtazashvilia, T., Frederich, M., & Angenot, L. (2006). Extraction and fractionation of cytotoxic metabolites from Galanthus lagodechianus Kem.-Nath. Allergology and Immunology (Moscou), 7, 649-650.
Otshudi, A. L., Apers, S., Pieters, L., Claeys, M., Pannecouque, C., De Clercq, E., Van Zeebroeck, A., Lauwers, S., Frederich, M., & Foriers, A. (31 October 2005). Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum. Journal of Ethnopharmacology, 102 (1), 89-94. doi:10.1016/j.jep.2005.05.021
Methanol and water extracts of the root of Epinetrum villosum (Exell) Troupin (Menispermaceae) we...
Philippe, G., Angenot, L., De Mol, P., Goffin, E., Hayette, M.-P., Tits, M., & Frederich, M. (21 March 2005). In vitro screening of some Strychnos species for antiplasmodial activity. Journal of Ethnopharmacology, 97 (3), 535-539. doi:10.1016/j.jep.2004.12.011
The antiplasmodial activity of crude extracts of 19 species of Strychnos (Loganiaceae) was assess...
Philippe, G., Angenot, L., Tits, M., & Frederich, M. (15 September 2004). About the toxicity of some Strychnos species and their alkaloids. Toxicon, 44 (4), 405-416. doi:10.1016/j.toxicon.2004.05.006
Poisons are widespread in plants and animals and humankind has often tried to turn them to its ow...
Frederich, M., Choi, Y. H., Angenot, L., Harnischfeger, G., Lefeber, A. W. M., & Verpoorte, R. (July 2004). Metabolomic analysis of Strychnos nux-vomica, Strychnos icaja and Strychnos ignatii extracts by H-1 nuclear magnetic resonance spectrometry and multivariate analysis techniques. Phytochemistry, 65 (13), 1993-2001. doi:10.1016/j.phytochem.2004.06.015
H-1 Nuclear magnetic resonance spectrometry and multivariate analysis techniques were applied for...
Frederich, M., Tits, M., Goffin, E., Philippe, G., Grellier, P., De Mol, P., Hayette, M.-P., & Angenot, L. (June 2004). In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis. Planta Medica, 70 (6), 520-525. doi:10.1055/s-2004-827151
Isostrychnopentamine (ISP) is an asymmetric indolomonoterpenic alkaloid isolated from the leaves ...
Ouattara, B., Angenot, L., Guissou, P., Fondu, P., Dubois, J., Frederich, M., Jansen, O., Van Heugen, J.-C., Wauters, J.-N., & Tits, M. (April 2004). LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry, 65 (8), 1145-1151. doi:10.1016/j.phytochem.2004.02.025
Gradient HPLC coupled to DAD/UV, MS/MS and NMR has been applied to the rapid structure determinat...
Choi, Y. H., Hazekamp, A., Peltenburg-Looman, A. M. G., Frederich, M., Erkelens, C., Lefeber, A. W. M., & Verpoorte, R. (2004). NMR assignments of the major Cannabinoids and cannabiflavonoids isolated from flowers of Cannabis sativa. Phytochemical Analysis, 15 (6, NOV-DEC), 345-354. doi:10.1002/pca.787
The complete H-1- and C-13-NMR assignments of the major Cannabis constituents, Delta(9)-tetrahydr...
De leval, X., Julémont, F., Benoit, V., Frederich, M., Pirotte, B., & Dogné, J.-M. (2004). First and second generations of COX-2 selective inhibitors. Mini Reviews in Medicinal Chemistry, 4, 597-601. doi:10.2174/1389557043403693
Dogné, J.-M., De leval, X., Hanson, J., Frederich, M., Lambermont, B., Ghuysen, A., Casini, A., Masereel, B., Ruan, K. E., Pirotte, B., & Kolh, P. (2004). New developments on thromboxane and prostacyclin modulators. Part I: thromboxane modulators. Current Medicinal Chemistry, 11, 1223-1241. doi:10.2174/0929867043365260
El-Sayed, M., Choi, Y. H., Frederich, M., Roytrakul, S., & Verpoorte, R. (2004). Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine. Biotechnology Letters, 26 (10), 793-798. doi:10.1023/B:BILE.0000025879.53632.f2
Feeding stemmadenine to Catharanthus roseus cell suspension culture resulted in the accumulation ...
Frederich, M., Cristino, A., Choi, Y. H., Verpoorte, R., Tits, M., Angenot, L., Prost, E., Nuzillard, J.-M., & Zèches-Hanrot, M. (January 2004). Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves. Planta Medica, 70 (1), 72-76. doi:10.1055/s-2004-815461
A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. Thi...
Frederich, M., Choi, Y. H., & Verpoorte, R. (December 2003). Quantitative analysis of strychnine and brucine in Strychnos nux-vomica using H-1-NMR. Planta Medica, 69 (12), 1169-1171. doi:10.1055/s-2003-818014
A quantitative analysis using H-1-NMR (Q-NMR) has been developed for the determination of strychn...
Goffin, E., da Cunha, A. P., Ziemons, E., Tits, M., Angenot, L., & Frederich, M. (November 2003). Quantification of tagitinin C in Tithonia diversifolia by reversed-phase high-performance liquid chromatography. Phytochemical Analysis, 14 (6), 378-80. doi:10.1002/pca.732
A simple, rapid and reliable reversed-phase high-performance liquid chromatographic method for th...
Frederich, M., Bentires-Ali, M., Tits, M., Angenot, L., Heinen, E., & De Pauw-Gillet, M.-C. (March 2003). Apoptosis induction in human cancer cells by sungucine from Strychnos icaja root. Naunyn-Schmiedeberg's Archives of Pharmacology, 367 (3), 260-265. doi:10.1007/s00210-003-0691-x
Sungucine (SG) and isosungucine (ISG) are bisindole alkaloids characterized by a 5'-23 link betwe...
Frederich, M., Bentires-Alj, M., Tits, M., Angenot, L., Greimers, R., Gielen, J., Bours, V., & Merville, M.-P. (March 2003). Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, induces cell cycle arrest and apoptosis in human colon cancer cells. Journal of Pharmacology and Experimental Therapeutics, 304 (3), 1103-1110. doi:10.1124/jpet.102.044867
Isostrychnopentamine (ISP) is an indolomonoterpenic alkaloid that is present in the leaves of Str...
Philippe, G., De Mol, P., Zeches-Hanrot, M., Nuzillard, J. M., Tits, M., Angenot, L., & Frederich, M. (February 2003). Indolomonoterpenic alkaloids from Strychnos icaja roots. Phytochemistry, 62 (4), 623-629. doi:10.1016/S0031-9422(02)00612-X
In the course of our search for new antiplasmodial alkaloids from Strychnos icaja, we have isolat...
Frederich, M., Tits, M., & Angenot, L. (2003). Indole alkaloids from Strychnos species and their antiplasmodial and cytotoxic activities. Chemistry of Natural Compounds, 39 (6, NOV-DEC), 513-519. doi:10.1023/B:CONC.0000018100.67335.b5
Strychnos species (Loganiaceae) have been studied in the laboratory of Pharmacognosy of the Unive...
Frederich, M., Jacquier, M. J., Thepenier, P., De Mol, P., Tits, M., Philippe, G., Delaude, C., Angenot, L., & Zeches-Hanrot, M. (October 2002). Antiplasmodial activity of alkaloids from various Strychnos species. Journal of Natural Products, 65 (10), 1381-1386. doi:10.1021/np020070e
The in vitro antiplasmodial activities of 69 alkaloids from various Strychnos species were evalua...
Frederich, M., Dogné, J.-M., Angenot, L., & De Mol, P. (August 2002). New trends in anti-malarial agents. Current Medicinal Chemistry, 9 (15), 1435-1456. doi:10.2174/0929867023369691
Malaria is the major parasitic infection in many tropical and subtropical regions, leading to mor...
Lansiaux, A., Bailly, C., Houssier, C., Colson, P., De Pauw-Gillet, M.-C., Frederich, M., Tits, M., & Angenot, L. (July 2002). Apoptosis of HL-60 leukemia cells induced by the bisindole alkaloids sungucine and isosungucine from Strychnos icaja. Planta Medica, 68 (7), 591-595. doi:10.1055/s-2002-32889
Sungucine and isosungucine are two bisindole alkaloids isolated from the roots of the African pla...
Goffin, E., Ziemons, E., De Mol, P., de Madureira, M. D. C., Martins, A. P., da Cunha, A. P., Philippe, G., Tits, M., Angenot, L., & Frederich, M. (June 2002). In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C. Planta Medica, 68 (6), 543-5. doi:10.1055/s-2002-32552
The antimalarial properties of Tithonia diversifolia, an Asteraceae traditionally used to treat m...
Philippe, G., Prost, E., Nuzillard, J. M., Zeches-Hanrot, M., Tits, M., Angenot, L., & Frederich, M. (29 April 2002). Strychnohexamine from Strychnos icaja, a naturally occurring trimeric indolomonoterpenic alkaloid. Tetrahedron Letters, 43 (18), 3387-3390. doi:10.1016/S0040-4039(02)00476-8
A reinvestigation of Strychnos icaja roots has resulted in the isolation, from the EtOAC extract,...
Penelle, J., Christen, P., Molgo, J., Tits, M., Brandt, V., Frederich, M., & Angenot, L. (October 2001). 5',6'-Dehydroguiachrysine and 5',6'-Dehydroguiaflavine, Two Curarizing Quaternary Indole Alkaloids from the Stem Bark of Strychnos Guianensis. Phytochemistry, 58 (4), 619-26. doi:10.1016/S0031-9422(01)00255-2
Two new quaternary indole alkaloids 5',6'-dehydroguiachrysine (1) and 5',6'-dehydroguiaflavine (2...
Frederich, M., Hayette, M.-P., Tits, M., De Mol, P., & Angenot, L. (August 2001). Reversal of Chloroquine and Mefloquine Resistance in Plasmodium Falciparum by the Two Monoindole Alkaloids, Icajine and Isoretuline. Planta Medica, 67 (6), 523-7. doi:10.1055/s-2001-16476
Eight naturally occurring monoindole alkaloids were evaluated in vitro for their ability to inhib...
Brandt, V., Tits, M., Penelle, J., Frederich, M., & Angenot, L. (July 2001). Main Glucosidase Conversion Products of the Gluco-Alkaloids Dolichantoside and Palicoside. Phytochemistry, 57 (5), 653-9. doi:10.1016/S0031-9422(01)00085-1
The enzymatic glucose cleavage of palicoside revealed the biosynthetic pathway to akagerine, wher...
Frederich, M., De Pauw-Gillet, M.-C., Prosperi, C., Tits, M., Brandt, V., Penelle, J., Hayette, M.-P., De Mol, P., & Angenot, L. (January 2001). Strychnogucines a and B, Two New Antiplasmodial Bisindole Alkaloids from Strychnos Icaja. Journal of Natural Products, 64 (1), 12-16. doi:10.1021/np000285t
A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-sy...
Frederich, M., De Pauw-Gillet, M.-C., Llabres, G., Tits, M., Hayette, M.-P., Brandt, V., Penelle, J., De Mol, P., & Angenot, L. (April 2000). New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots. Planta Medica, 66 (3), 262-9. doi:10.1055/s-2000-8559
Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine a...
Penelle, J., Tits, M., Christen, P., Molgo, J., Brandt, V., Frederich, M., & Angenot, L. (April 2000). Quaternary Indole Alkaloids from the Stem Bark of Strychnos Guianensis. Phytochemistry, 53 (8), 1057-66. doi:10.1016/S0031-9422(00)00033-9
Two new quaternary alkaloids, 9-methoxy-Nb-methylgeissoschizol and guiachrysine together with the...
Frederich, M., Hayette, M.-P., Tits, M., De Mol, P., & Angenot, L. (September 1999). In Vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium Falciparum. Antimicrobial Agents and Chemotherapy, 43 (9), 2328-31. doi:10.1128/aac.43.9.2328
The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were eva...
Penelle, J., Tits, M., Christen, P., Brandt, V., Frederich, M., & Angenot, L. (June 1999). Guiaflavine, a New Bisindole Quaternary Alkaloid from the Stem Bark of Strychnos Guianensis. Journal of Natural Products, 62 (6), 898-900. doi:10.1021/np9804738
A reinvestigation of Strychnos guianensis resulted in the isolation of a colored quaternary bisin...
Frederich, M., Tits, M., Hayette, M.-P., Brandt, V., Penelle, J., De Mol, P., Llabres, G., & Angenot, L. (April 1999). 10'-Hydroxyusambarensine, a New Antimalarial Bisindole Alkaloid from the Roots of Strychnos Usambarensis. Journal of Natural Products, 62 (4), 619-21. doi:10.1021/np980375m
Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic b...
Brandt, V., Tits, M., Geerlings, A., Frederich, M., Penelle, J., Delaude, C., Verpoorte, R., & Angenot, L. (1999). beta-carboline glucoalkaloids from Strychnos mellodora. Phytochemistry, 51 (8), 1171-1176. doi:10.1016/S0031-9422(99)00129-6
Dassonneville, L., Wattez, N., Mahieu, C., Colson, P., Houssier, C., Frederich, M., Tits, M., Angenot, L., & Bailly, C. (1999). The plant alkaloid usambarensine intercalates into DNA and induces apoptosis in human HL60 leukemia cells. Anticancer Research, 19 (6B), 5245-5250.
Biala, R. G., Tits, M., Penelle, J., Frederich, M., Brandt, V., Prosperi, C., Llabres, G., & Angenot, L. (23 January 1998). Strychnochrysine, a New Bisindole Alkaloid from the Roots of Strychnos Nux-Vomica. Journal of Natural Products, 61 (1), 139-41. doi:10.1021/np9703454
The reinvestigation of Strychnos nux-vomica resulted in the isolation of a colored monoquaternary...
Frederich, M., Quetin-Leclercq, J., Biala, R. G., Brandt, V., Penelle, J., Tits, M., & Angenot, L. (1998). 3 ',4 ',5 ',6 ' tetradehydrolongicaudatine Y, an anhydronium base from Strychnos usambarensis. Phytochemistry, 48 (7), 1263-1266. doi:10.1016/S0031-9422(97)00944-8
Frederich, M., Tits, M., & Angenot, L. (1998). Qualitative and quantitative evaluation of bisindole usambarane alkaloids in Strychnos usambarensis roots by high performance liquid chromatography diode-array. Phytochemical Analysis, 9 (2), 63-66. doi:10.1002/(SICI)1099-1565(199803/04)9:2<63::AID-PCA388>3.0.CO;2-9
A high performance liquid chromatographic method for the simultaneous determination of bisindole ...