Kowa, T., Jansen, O., Ledoux, A., Coelho Cristino Mamede, L. C., Wabo, H., Tchinda Tiabou, A., Genta-Jouve, G., & Frederich, M. (2021, May 06). Bioassay-guided isolation of vilasinin–type limonoids and phenyl alkene from the leaves of Trichilia gilgiana and their antiplasmodial activities. Natural Product Research.
Peer reviewed (verified by ORBi)
Degotte, G., Pirotte, B., Francotte, P., & Frederich, M. (2021, March). Overview of natural antiplasmodials from the last decade to inspire medicinal chemistry. Current Medicinal Chemistry.
Peer reviewed (verified by ORBi)
Background: Despite the major advances in the fight against this parasitic disease, malaria remains a major cause of concerns in 2020. This infection, mainly due to Plasmodium falciparum, causes every year ...
Toukam, P. D., Kom, C. W., Tchamgoué, A. D., Doupno, E. A. K., Lame, Y., Yamthé, L. R. T., Kopa Kowa, T., Tchinda, A. T., Frederich, M., Mbafor, J. T., & De Théodore Atchadé, A. (2021, February 24). A new isoquinoline and ceramide from the stem barks of Discoglypremna caloneura (Pax) Prain (Euphorbiaceae) with antiproteinase and cytotoxic activities. Natural Product Research, 1-9.
Peer reviewed (verified by ORBi)
Two new compounds, an isoquinoline (1) and caloneuramide (2), a ceramide were isolated from the stem bark of Discoglypremna caloneura together with seven known compounds namely aurantiamide acetate (3 ...
Ma'mag, L. K., Zintchem, A. A. A., Théodora, K. K., Théodore, A. A. D., lauve, T. Y., Frederich, M., Bikobo, D. S. N., & Pegnyemb, D. E. (2021). Antiplasmodial and antileishmanial inhibitory activity of triterpenes and steroidal alkaloid from the leaves of Funtumia elastica (Preuss) Stapf (Apocynaceae). Fitoterapia, 104869.
Peer reviewed (verified by ORBi)
The phytochemical study of leaves of Funtumia elastica led to the isolation of three undescribed ursane derivatives, funtumic acids A, B and C (1–3), as well as one steroidal alkaloid, elasticine (4) and five ...
Nea, F., Bitchi, M. B., Genva, M., Ledoux, A., Tchinda Tiabou, A., Damblon, C., Frederich, M., Tonzibo, Z. F., & Fauconnier, M.-L. (2021). Phytochemical investigation and biological activities of Lantana rhodesiensis. Molecules, 26(4), 846.
Peer reviewed (verified by ORBi)
Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabetes, and malaria in traditional medicine. To better understand the traditional uses of this plant, a ...
Saive, M.* , Genva, M.* , Istasse, T., Frederich, M., Maes, C., & Fauconnier, M.-L. (2020). Identification of a proanthocyanidin from Litchi chinensis Sonn. root with anti-tyrosinase and antioxidant activity. Biomolecules, 10(9), 1347.
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This work follows an ethnobotanical study that took place in the island of Mayotte (France), which pointed out the potential properties of Litchi chinensis Sonn. roots when used to enhance skin health and ...
* These authors have contributed equally to this work.
Kagisha, V., Frederich, M., Ledoux, A., Jansen, O., NYIRIMIGABO, A., MUGANGA, R., & Marini Djang'Eing'A, R. (2020). HPLC-UV Method for Standardization of Neorautanenia mitis, an African Plant Used in an Anti-Scabies Ointment. Revista Brasileira de Farmacognosia, 30(4), 582-587.
Peer reviewed (verified by ORBi)
An HPLC-UV method for standardization of the methanol-soluble extracts from tubers of Neorautanenia mitis (A.Rich.) Verdc., Fabaceae, harvested during different periods and from different sites, is described ...
Ledoux, A., Mamede, L., Palazzo, C., Furst, T., Jansen, O., De Tullio, P., Kagisha, V., Pendeville-Samain, H., Fillet, M., Piel, G., & Frederich, M. (2020). Heparin-Coated Liposomes Improve Antiplasmodial Activity and Reduce the Toxicity of Poupartone B. Planta Medica International Open, 7(e), 73–80.
Peer reviewed
Poupartone B is an alkyl cyclohexenone derivative isolated from Poupartia borbonica. This compound demonstrated promising antimalarial activity (IC50 < 1 μg/mL), however, it was not de- void of toxicity. Thus ...
Kowa, T., Tchokouaha, L., Nyemb, J.-N., Wabo, H., Tchinda, A., Appiah-Opong, R., Agbor, G., Tane, P., & Frederich, M. (2020). Antipromastigote and cytotoxic activities of some chemical constituents of Hypericum lanceolatum Lam. Journal of Applied Pharmaceutical Science, 10, 26-32.
Peer reviewed (verified by ORBi)
Phytochemical investigation of the ethanol extract of the stem bark of Hypericum lanceolatum Lam. (Guttifereae) afforded eight known compounds including 2,2ʹ,5,6ʹ-tetrahydroxybenzophenone (1), 5-hydroxy-3 ...
Catteau, L., Schioppa, L., Beaufay, C., Girardi, C., Hérent, M.-F., Frederich, M., & Quetin-Leclercq, J. (2020). Antiprotozoal activities of Triterpenic Acids and Ester Derivatives Isolated from the Leaves of Vitellaria paradoxa. Planta Medica.
Peer reviewed (verified by ORBi)
Leaves of Vitellaria paradoxa, also called "Shea butter tree", are used in traditional medicine to treat various symptoms including malaria fever, dysentery, or skin infections. Composition of the ...