[en] Five labdane diterpenoids, (3-5), zambesiacolactone A (7) and zambesiacolactone B (8), were isolated from the seeds of Aframomum zambesiacum (Baker) K. Schum., along with five known labdanes and a linear sesquiterpene, nerolidol. Their structures were elucidated by spectroscopic analysis. Their antiplasmodial activity was evaluated in vitro against Plasmodium falciparum. Compound 3 was the most active with an IC50 value of 4.97 mu M. (c) 2005 Elsevier Ltd. All rights reserved.
P.M. Abreu, and R.G. Noronha Volatile constituents of the rhizomes of Aframomum alboviolaceum (Ridley) K. Schum from Guinea-Bissau Flavour and Fragrance J. 12 1997 79 83
J.F. Ayafor, and J.D. Connolly 2R,3R-(+)-3-Acetoxy-4′,5-dihydroxy- 7-methoxyflavanone and 2R,3R-(+)-3-acetoxy-4′,5,7-trihydroxyflavanone: two new 3-acetylated dihydroflavonols from Aframomum pruinosum Gagnepain (Zingiberaceae) J. Chem. Soc., Perkin Trans. 1 1981 2563 2565
J.F. Ayafor, M.H.K. Tchuendem, and B. Nyasse Novel bioactive diterpenoids from Aframomum aulacocarpos J. Nat. Prod. 57 1994 917 923
J.F. Ayafor, M.H.K. Tchuendem, B. Nyasse, F. Tillequin, and H. Anke Aframodial and other bioactive diterpenoids from Aframomum species Pure & Appl. Chem. 66 1994 2327 2330
G.A. Ayimele, P. Tane, and J.D. Connolly Aulacocarpin A and B, nerolidol and β-sitosterol glucoside from Aframomum escapum Biochem. Syst. Ecol. 32 2004 1205 1207
M. De Bernardi, G. Vidari, and P. Vita-Finzi Dehydrozyngerone from Aframomum giganteum Phytochemistry 15 1976 1785 1786
L. Delhaes, J.-E. Lazaro, F. Gay, M. Thellier, and M. Danis The microculture tetrazolium assay: another colorimetric method of testing Plasmodium falciparum chemosensitivity Ann. Trop. Med. Parasitol. 93 1999 31 40
G. Duker-Eshun, J.W. Jaroszewski, W.A. Asomaning, F. Oppong-Boachie, C.E. Olsen, and S.B. Christensen Antiplasmodial activity of labdanes from Aframomum latifolium and Aframomum sceptrum Planta Med. 68 2002 642 644
M. Frédérich, M.J. Jacquier, P. Thépnier, P. De Mol, M. Tits, G. Philippe, C. Delaude, L. Angenot, and M. Zèches-Hanrot Antiplasmodial activity of alkaloids from various Strychnos species J. Nat. Prod. 65 2002 1381 1386
S. Huneck, J.D. Connolly, L.J. Harrison, R. Joseph, W.R. Phillips, D.S. Rycroft, G. Ferguson, and M. Parvez New labdane diterpenoids from the liverwort Scapania undulata J. Chem. Res., Synopses 1986 162 163
M. Iwu Handbook of African Medicinal Plants 1993 CRC Press Boca Raton, FL
P. Kamnaing, A. Tsopmo, E.A. Tanifum, M.H.K. Tchuendem, P. Tane, J.F. Ayafor, O. Sterner, D. Rattendi, M.M. Iwu, B. Schuster, and C. Bacchi Trypanocidal diarylheptanoids from Aframomum letestuianum J. Nat. Prod. 66 2003 364 367
S.F. Kimbu, T.K. Njimi, B.L. Sondengam, J.A. Akinniyi, and J.D. Connolly The structure of a labdane dialdehyde from Aframomum daniellii (Zingiberaceae) J. Chem. Soc., Perkin Trans. 1 1979 1303 1304
S.F. Kimbu, B. Ngadjui, and B.L. Sondengam A new labdane diterpenoid from the seeds of Aframomum daniellii J. Nat. Prod. 50 1987 230 231
M. Makler, J. Ries, J. Williams, J. Bancroft, R. Piper, B. Gibbins, and D. Hinrichs Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity Am. J. Trop. Med. Hyg. 48 1993 739 741
H. Morita, and H. Itokawa Cytotoxic and antifungal diterpenes from the seeds of Alpinia galanga Planta Med. 54 1988 117 120
E. Scio, A. Ribeiro, T.M.A. Alves, A.J. Romanha, J.D. De Souza Filho, G.A. Cordell, and C.L. Zani Diterpenes from Alomia myriadenia (Asteraceae) with cytotoxic and trypanocidal activity Phytochemistry 64 2003 1125 1131
M. Singh, M. Pal, and R.P. Sharma Biological activity of labdane diterpenes Planta Med. 65 1999 2 8
C. Tomla, P. Kamnaing, G.A. Ayimele, E.A. Tanifum, A. Tsopmo, P. Tane, J.F. Ayafor, and J.D. Connolly Three labdane diterpenoids from Aframomum sceptrum (Zingiberaceae) Phytochemistry 60 2002 197 200
Thomas, D.W., Thomas, J., Bromley, W.N., Mbenkum, F.T., 1989. Korup ethnobotany survey, final report to: The World Wide Fund for Nature, Penda House: Weyside Park, Godalming: Surrey, UK.
W. Trager, and J.B. Jensen Human malaria parasites in continuous culture Science 193 1976 673 675
