Article (Scientific journals)
Indolomonoterpenic alkaloids from Strychnos icaja roots
Philippe, Geneviève; De Mol, Patrick; Zeches-Hanrot, M. et al.
2003In Phytochemistry, 62 (4), p. 623-629
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Keywords :
Loganiaceae; Strychnos icaja; indolomonoterpenic alkaloid; strychnogucine C; protostrychnine; strychnohexamine; Plasmodium falciparum
Abstract :
[en] In the course of our search for new antiplasmodial alkaloids from Strychnos icaja, we have isolated five alkaloids: three monomers, protostrychnine and genostrychnine, previously described in Strychnos nux-vomica, pseudostrychnine, already found in the leaves of the plant, a new bisindolic alkaloid, named strychnogucine C, and the first naturally occurring trimeric indolomonoterpenic alkaloid: strychnohexamine. This latter trimeric alkaloid presented an antiplasmodial activity against the FCA Plasmodium falciparum line near I muM. (C) 2002 Elsevier Science Ltd. All rights reserved.
Disciplines :
Phytobiology (plant sciences, forestry, mycology...)
Biochemistry, biophysics & molecular biology
Author, co-author :
Philippe, Geneviève  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
De Mol, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
Zeches-Hanrot, M.
Nuzillard, J. M.
Tits, Monique 
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Indolomonoterpenic alkaloids from Strychnos icaja roots
Publication date :
February 2003
Journal title :
Phytochemistry
ISSN :
0031-9422
eISSN :
1873-3700
Publisher :
Pergamon-Elsevier Science Ltd, Oxford, United Kingdom
Volume :
62
Issue :
4
Pages :
623-629
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 June 2009

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