10'-Hydroxyusambarensine, a New Antimalarial Bisindole Alkaloid from the Roots of Strychnos Usambarensis

[en] Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods. Compound 1 was moderately active against two strains of Plasmodium falciparum in vitro.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie

Hayette, Marie-Pierre ; Université de Liège - ULiège > Microbiologie médicale

Brandt, Viviane

Penelle, Jacques

De Mol, Patrick ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale

Llabres, Gabriel ; Université de Liège - ULiège > Département de physique > Département de physique

Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Language :

English

Title :

10'-Hydroxyusambarensine, a New Antimalarial Bisindole Alkaloid from the Roots of Strychnos Usambarensis

Publication date :

April 1999

Journal title :

Journal of Natural Products

ISSN :

0163-3864

eISSN :

1520-6025

Publisher :

American Chemical Society, Washington, United States - District of Columbia

Volume :

Issue :

Pages :

619-21

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 February 2009

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