[en] A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Chrysopentamine presented an original hydroxy substitution on C-14 and an aromatization of the ring D of strychnopentamine leading to anhydronium base proper-ties and exhibited strong antiplasmodial properties (IC50 less than 1 muM).
Angenot L, Denoel A, Goffart M. Activité curarisante d'un Strychnos africain: le Strychnos usambarensis GiIg du Rwanda. J Pharm Belg 1970; 25: 73-7
Angenot L, Coune C, Tits M. Nouveaux alcaloïdes des feuilles du Strychnos usambarensis. J Pharm Belg 1978; 33: 11-23
Angenot L. Nouveaux alcaloïdes des feuilles du Strychnos usambarensis. Planta Med 1975; 27: 24-30
Wright CW, Bray DH, O'Neill MJ, Warhurst DC, Phillipson JD, Quetin-Leclercq J et al. Antiamoebic and antiplasmodial activities of alkaloids isolated from Strychnos usambarensis. Planta Med 1991; 57: 337-40
Frederich M, Hayette MP, Tits M, De Mol P, Angenot L. In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum. Antimicrob Agents Chemother 1999; 43: 2328-31
Frederich M, Bentires-Alj M, Tits M, Angenot L, Greimers R, Gielen J et al. Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, induces cell cycle arrest and apoptosis in human colon cancer cells. J Pharmacol Exp Ther 2003; 304: 1103-10
Angenot L, Denoel A. Alcaloides des Loganiacées: sur l'isolement d'un nouvel alcaloide à partir du Strychnos usambarensis. Planta Med 1973; 23: 226-32
Tavernier D, Zhang W, Angenot L, Tits M, Leclercq J. The structure of isostrychnopentamine, a bisindole monoterpene alkaloid from Strychnos usambarensis. Phytochemistry 1987; 26: 557-60
Caprasse M, Angenot L, Tavernier D, Anteunis MJO. Isolement et détermination de structure de l'afrocurarine. Planta Med 1984; 50: 131-3
Biala RG, Tits M, Penelle J, Frederich M, Brandt V, Prosperi C et al. Strychnochrysine, a new bisindole alkaloid from the roots of Strychnos nuxvomica. J Nat Prod 1998; 61: 139-41
Yamanaka E, Maruta E, Kasamatsu S, Aimi N, Sakai SI. An indole alkaloid, 14-alpha-hydroxyrauniticine: structure revision and partial synthesis. Chem Pharm Bull 1986; 34: 3713-21
Angenot L, Coune C, Tits M, Yamada K. Alkaloids from Strychnos usambarensis: revised structure for usambarine. Phytochemistry 1978; 17: 1687-9
Koch M, Plat M, Reaux N. Hémisynthèse et stéréochimie des ochrolifuanines A et B, alcaloïdes d' Ochrosia lifuana Guill. (apocynacées). Bull Soc Chim Fr 1973; 9: 2868-9
Dupont L, Lamotte-Brasseur J, Dideberg O, Campsteyn H, Vermeire M, Angenot L. La structure cristalline et moléculaire d'un nouvel alcaloïde bisindolique: la Strychnopentamine, C35H 43N50. J Crystallogr B 1977: B33: 1801-7
Philippe G, DeMol P, Zèches-Hanrot M, Nuzillard JM, Tits M, Angenot L, Frederich M. Indolomonoterpenic alkaloids from Strychnos icaja roots. Phytochemistry 2003; 62: 623-9
Trager W, Jensen JB. Human malaria parasites in continuous culture. Science 1976; 193: 673-5
Frederich M, Jacquier MJ, Thepenier P, De Mol P, Tits M, Philippe G et al. Antiplasmodial activity of alkaloids from various Strychnos species. J Nat Prod 2002; 65: 1381-6
Desjardins RE, Canfield CJ, Haynes JD, Chulay JD. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Agents Chemother 1979; 16: 710-8
Mirovsky P, Gay F, Bustos D, Mazier D, Gentilini M. Cloning of a fresh isolate of Plasmodium falciparum and drug sensitivity of the clones. Trans R Soc Trop Med Hyg 1990; 84: 511-5