Article (Scientific journals)
Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves
Frederich, Michel; Cristino, Assunção; Choi, Young Hae et al.
2004In Planta Medica, 70 (1), p. 72-76
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Keywords :
antiplasmodial activity; Strychnos; Plasmodium falciparum; indole alkaloid; indolomonoterpenoid
Abstract :
[en] A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Chrysopentamine presented an original hydroxy substitution on C-14 and an aromatization of the ring D of strychnopentamine leading to anhydronium base proper-ties and exhibited strong antiplasmodial properties (IC50 less than 1 muM).
Disciplines :
Pharmacy, pharmacology & toxicology
Phytobiology (plant sciences, forestry, mycology...)
Chemistry
Author, co-author :
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Cristino, Assunção
Choi, Young Hae
Verpoorte, Robert
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Prost, Elise
Nuzillard, Jean-Marc
Zèches-Hanrot, Monique
Language :
English
Title :
Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves
Publication date :
January 2004
Journal title :
Planta Medica
ISSN :
0032-0943
eISSN :
1439-0221
Publisher :
Georg Thieme Verlag Kg, Stuttgart, Germany
Volume :
70
Issue :
1
Pages :
72-76
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 February 2009

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