Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves

[en] A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Chrysopentamine presented an original hydroxy substitution on C-14 and an aromatization of the ring D of strychnopentamine leading to anhydronium base proper-ties and exhibited strong antiplasmodial properties (IC50 less than 1 muM).

Disciplines :

Pharmacy, pharmacology & toxicology
Phytobiology (plant sciences, forestry, mycology...)
Chemistry

Author, co-author :

Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Cristino, Assunção

Choi, Young Hae

Verpoorte, Robert

Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie

Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Prost, Elise

Nuzillard, Jean-Marc

Zèches-Hanrot, Monique

Language :

English

Title :

Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves

Publication date :

January 2004

Journal title :

Planta Medica

ISSN :

0032-0943

eISSN :

1439-0221

Publisher :

Georg Thieme Verlag Kg, Stuttgart, Germany

Volume :

Issue :

Pages :

72-76

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 February 2009

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