Phenolic compounds from the roots of Ochna schweinfurthiana and their antioxidant and antiplasmodial activities

[en] An investigation of compounds extracted from Ochna schweinfurthiana roots with ethyl acetate led to the isolation of three new compounds 4‴-methoxylophirone A (1), 4,4′,4‴–trimethoxylophirone A (2) and (4E;7Z)-3,8-dicarboxy-1-(O-β-D-glucopyranosyl-(1 → 6)-O-β-D-glucopyranosyl-2,9-dihydroxyhexeicosa-4,7-diene (3). Six known compounds were also identified, including Calodenone (4), Calodenine B (5), Lophirone A (6), Gerontoisoflavone A(7), 16α,17-dihydroxy-ent-kauran-19-oic acid (8) and 3β-O-D-glucopyranosyl-β-sitosterol (9). This report describes the first time that compounds 4-8 have been isolated from this plant, while 8 has never been identified in the genus Ochna. Some of the isolated compounds were evaluated for their antiplasmodial activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7 and antioxidant activity using DPPH radical scavenging and Ferric reducing-antioxidant power (FRAP) assays. Compound 5 exhibited prominent radical scavenging and FRAP activities, while 7 had weak activity. Compound 1 showed good in vitro anti-plasmodial activity. The structures of the isolated compounds were elucidated by spectroscopic methods and comparisons with prior data in the literature. © 2016 Phytochemical Society of Europe

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Messi, A. N.; Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon

Ngo Mbing, J.; Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon, Centre de Recherche en Plantes Médicinales et Médecine Traditionnelle (CRPMT), I.M.P.M, Yaoundé, Cameroon

Ndongo, J. T.; Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, P. O. Box 47, Yaoundé, Cameroon

Nyegue, M. A.; Laboratory of Microbiology, Faculty of science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon

Tchinda, A. T.; Centre de Recherche en Plantes Médicinales et Médecine Traditionnelle (CRPMT), I.M.P.M, Yaoundé, Cameroon

Yemeda, F. L.; Laboratory of Microbiology, Faculty of science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon

Frederich, Michel ; Université de Liège > Département de pharmacie > Pharmacognosie

Pegnyemb, D. E.; Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon

Language :

English

Title :

Phenolic compounds from the roots of Ochna schweinfurthiana and their antioxidant and antiplasmodial activities

Publication date :

2016

Journal title :

Phytochemistry Letters

ISSN :

1874-3900

eISSN :

1876-7486

Publisher :

Elsevier, Amsterdam, Netherlands

Volume :

Pages :

119-125

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 November 2016

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