Reference : Phenolic compounds from the roots of Ochna schweinfurthiana and their antioxidant and...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/203141
Phenolic compounds from the roots of Ochna schweinfurthiana and their antioxidant and antiplasmodial activities
English
Messi, A. N. [Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon]
Ngo Mbing, J. [Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon, Centre de Recherche en Plantes Médicinales et Médecine Traditionnelle (CRPMT), I.M.P.M, Yaoundé, Cameroon]
Ndongo, J. T. [Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, P. O. Box 47, Yaoundé, Cameroon]
Nyegue, M. A. [Laboratory of Microbiology, Faculty of science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon]
Tchinda, A. T. [Centre de Recherche en Plantes Médicinales et Médecine Traditionnelle (CRPMT), I.M.P.M, Yaoundé, Cameroon]
Yemeda, F. L. [Laboratory of Microbiology, Faculty of science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon]
Frederich, Michel mailto [Université de Liège > Département de pharmacie > Pharmacognosie >]
Pegnyemb, D. E. [Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon]
2016
Phytochemistry Letters
Elsevier
17
119-125
Yes (verified by ORBi)
International
1874-3900
Amsterdam
The Netherlands
[en] Antioxidant and antiplasmodial activities ; Isobiflavonoid ; Ochnaceae ; Structural elucidation
[en] An investigation of compounds extracted from Ochna schweinfurthiana roots with ethyl acetate led to the isolation of three new compounds 4‴-methoxylophirone A (1), 4,4′,4‴–trimethoxylophirone A (2) and (4E;7Z)-3,8-dicarboxy-1-(O-β-D-glucopyranosyl-(1 → 6)-O-β-D-glucopyranosyl-2,9-dihydroxyhexeicosa-4,7-diene (3). Six known compounds were also identified, including Calodenone (4), Calodenine B (5), Lophirone A (6), Gerontoisoflavone A(7), 16α,17-dihydroxy-ent-kauran-19-oic acid (8) and 3β-O-D-glucopyranosyl-β-sitosterol (9). This report describes the first time that compounds 4-8 have been isolated from this plant, while 8 has never been identified in the genus Ochna. Some of the isolated compounds were evaluated for their antiplasmodial activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7 and antioxidant activity using DPPH radical scavenging and Ferric reducing-antioxidant power (FRAP) assays. Compound 5 exhibited prominent radical scavenging and FRAP activities, while 7 had weak activity. Compound 1 showed good in vitro anti-plasmodial activity. The structures of the isolated compounds were elucidated by spectroscopic methods and comparisons with prior data in the literature. © 2016 Phytochemical Society of Europe
http://hdl.handle.net/2268/203141
10.1016/j.phytol.2016.07.011

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