Nuclear magnetic resonance: a key metabolomics platform in the drug discovery process.

[en] Metabolomics is an innovative tool that is now emerging in the drug discovery process. Indeed, its ability to follow the dynamic perturbations in the metabolome resulting from pathologies but also from drug treatment and or/toxicity is of value for the development of new therapeutic approaches. Nuclear magnetic resonance (NMR) spectroscopy, which is an important analytical technique for several steps of the lead discovery, validation and optimization processes, has been described, together with mass spectrometry (MS) as one of the major platform that could be used for metabolomics studies. This review highlights why NMR could be considered a key tool for the application of metabolomics in drug discovery.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Leenders, Justine ; Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Frederich, Michel ; Université de Liège - ULiège

De Tullio, Pascal ; Université de Liège > Département de pharmacie > Chimie pharmaceutique

Language :

English

Title :

Nuclear magnetic resonance: a key metabolomics platform in the drug discovery process.

Publication date :

2015

Journal title :

Drug Discovery Today. Technologies

eISSN :

1740-6749

Publisher :

Elsevier, Netherlands

Volume :

Pages :

39-46

Peer reviewed :

Peer reviewed

Commentary :

Available on ORBi :

since 13 October 2015

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