Isolation, pharmacological activity and structure determination of physalin B and 5[beta],6[beta]-epoxyphysalin B isolated from Congolese Physalis angulata L.
Mangwala Kimpende, P.; Lusakibanza, M.; Mesia, K.et al.
2013 • In Acta Crystallographica. Section C, Structural Chemistry, C69, p. 1557-1562
[en] Physalis angulata L., an annual herb from the Solanaceae family, is widely used in popular medicine in tropical countries to treat a variety of diseases. Two products, (X) and (Y), were isolated from a crude CH2Cl2 extract of dried Congolese Physalis angulata L. plants and crystallized from acetone for structure elucidation. Compound (X) corresponds to a physalin B dimer acetone solvate hydrate (2C28H30O9·C3H6O·0.22H2O), while compound (Y) crystallizes as a mixed crystal containing two physalin B molecules which overlap with 5[beta],6[beta]-epoxyphysalin B, also known as physalin F, and one acetone molecule in the asymmetric unit (1.332C28H30O9·0.668C28H30O10·C3H6O). Antiplasmodial activity, cytotoxic activity and selectivity indices were determined for crude extracts and the two isolated products (X) and (Y).
Disciplines :
Chemistry Pharmacy, pharmacology & toxicology
Author, co-author :
Mangwala Kimpende, P.
Lusakibanza, M.
Mesia, K.
Tona, L.
Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Van Meervelt, Luc
Language :
English
Title :
Isolation, pharmacological activity and structure determination of physalin B and 5[beta],6[beta]-epoxyphysalin B isolated from Congolese Physalis angulata L.
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