In vitro screening of some Strychnos species for antiplasmodial activity

[en] The antiplasmodial activity of crude extracts of 19 species of Strychnos (Loganiaceae) was assessed in vitro against a chloroquine-susceptible strain of Plasmodium falciparum. For each species, ethyl acetate (EtOAc) extracts were analysed and, for the most active species, methanolic (MeOH) extracts were also tested. Among them, Strychnos variabilis De Wild. seemed to be very promising (inhibitory concentration 50% (IC50) < 5 microg/ml) whereas two other species, Strychnos gossweileri Exell and Strychnos mellodora S. Moore, could be interesting (IC50 < 15 microg/ml) in further antimalarial studies.

Disciplines :

Pharmacy, pharmacology & toxicology
Chemistry
Phytobiology (plant sciences, forestry, mycology...)

Author, co-author :

Philippe, Geneviève ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

De Mol, Patrick ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale

Goffin, Eric ; Université de Liège - ULiège > Chimie pharmaceutique

Hayette, Marie-Pierre ; Université de Liège - ULiège > Microbiologie médicale

Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie

Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Language :

English

Title :

In vitro screening of some Strychnos species for antiplasmodial activity

Publication date :

21 March 2005

Journal title :

Journal of Ethnopharmacology

ISSN :

0378-8741

eISSN :

1872-7573

Publisher :

Elsevier Sci Ireland Ltd, Clare, Ireland

Volume :

Issue :

Pages :

535-539

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 09 April 2009

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