In Vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium Falciparum

[en] The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC(50)] approximately 0.15 microM), while dihydrousambarensine exhibited a 30-fold higher activity against the chloroquine-resistant strain (IC(50) = 0.03 microM) than it did against the chloroquine-sensitive strain.

Disciplines :

Microbiology
Pharmacy, pharmacology & toxicology

Author, co-author :

Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Hayette, Marie-Pierre ; Université de Liège - ULiège > Microbiologie médicale

Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie

De Mol, Patrick ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale

Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Language :

English

Title :

In Vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium Falciparum

Publication date :

September 1999

Journal title :

Antimicrobial Agents and Chemotherapy

ISSN :

0066-4804

eISSN :

1098-6596

Publisher :

American Society for Microbiology, Washington, United States - District of Columbia

Volume :

Issue :

Pages :

2328-31

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 February 2009

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