Substituted azafluorenones: access from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes and evaluation of their antibacterial, antifungal, antimalarial and antiproliferative activities
[en] Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions. Different dihalogenated diaryl ketones, prepared by sequential deprotocupration-aroylation, were identified as suitable substrates to this purpose. Conditions were identified to allow successful syntheses of several 6-/7-arylated 4-azafluorenones, 1-substituted 4-azafluorenones, 2-phenyl-3-azafluorenone, and 4-phenyl-3-azafluorenone from 3-(bromobenzoyl)-2-chloropyridines, 3-benzoyl-4-bromo-2-chloropyridines, 4-benzoyl-2,5-dichloropyridine, and 4-benzoyl-2,3-dichloropyridine, respectively. Some of the synthesized compounds exhibit interesting biological properties
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Marquise, Nada; Université de Rennes > Chimie et Photonique Moléculaires
Chevallier, Floris; Université de Rennes > Chimie et Photonique Moléculaires
Nassar, Ekhlas
Frederich, Michel ; Université de Liège > Département de pharmacie > Pharmacognosie
Ledoux, Allison ; Université de Liège > Département de pharmacie > Pharmacognosie
Halauko, Yury S
Ivashkevich, Oleg A
Matulis, Vadim E
Roisnel, Thierry
Dorcet, Vincent
Mongin, Florence
Language :
English
Title :
Substituted azafluorenones: access from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes and evaluation of their antibacterial, antifungal, antimalarial and antiproliferative activities
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