Reference : A 1H NMR-based metabolomic approach to study the production of antimalarial compounds...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/247928
A 1H NMR-based metabolomic approach to study the production of antimalarial compounds from Psiadia arguta leaves (pers.) voigt
English
Mahadeo, Keshika [> >]
Grondin, Isabelle [> >]
Herbette, Gaëtan [> >]
Palama, Tony L. [> >]
Bouchemal, Nadia [> >]
Soulange, Joyce [> >]
Laulloo, Sabina Jhaumeer [> >]
Sadeyen, Joelle [> >]
Humeau, Laurence [> >]
Frederich, Michel mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
Gauvin-Bialecki, Anne [> >]
Kodja, Hippolyte [> >]
2020
Phytochemistry
Elsevier
176
112401
Yes (verified by ORBi)
International
00319422
18733700
Netherlands
[en] Asteraceae ; Antimalarial diterpenes ; Metabolomic ; NMR ; Multivariate data analysis
[en] Psiadia arguta (Asteraceae) is endemic to the island of Mauritius in the Indian Ocean. The species is traditionally used to treat various ailments, such as its use as an expectorant or for the treatment of bronchitis and asthma. Preliminary biological screenings have displayed the antimalarial (Plasmodium falciparum) and anticancer (HeLa human cell line) potential of P. arguta leaves. The phytochemical investigation of this plant has led to the isolation and characterization of sixteen compounds including five antiplasmodial molecules. The accumulation of the antiplasmodial compounds during the growth of the plant was studied by a 1H NMR-based metabolomic approach. In order to identify factors influencing the production of bioactive compounds, young plants of P. arguta were multiplied using in vitro culture techniques, and micro-propagated plants at different stages of development were acclimatized and followed for the experiments. The multivariate data analysis showed an accumulation of four bioactive compounds in the leaves of P. arguta when these plants were challenged with a biotic stress: labdan-13(E)-en-8α-ol-15-yl acetate, labdan-8α-ol-15-yl acetate, labdan-13(E)-ene-8α-ol-15-diol, and (8R,13S)-labdan-8,15-diol.
Centre Interdisciplinaire de Recherche sur le Médicament - CIRM
http://hdl.handle.net/2268/247928
10.1016/j.phytochem.2020.112401
http://www.sciencedirect.com/science/article/pii/S0031942219312129

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
1-s2.0-S0031942219312129-main-2.pdfPublisher postprint1.8 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.