Article (Scientific journals)
Antrocarines A-F, antiplasmodial ergostane steroids from the stem bark of Antrocaryon klaineanum.
Douanla, Pascal D.; Tabopda, Turibio Kuiate; Tchinda, Alembert T. et al.
2015In Phytochemistry, 117, p. 521-6
Peer Reviewed verified by ORBi
 

Files


Full Text
Antrocarines_reprint_Phytochemistry.pdf
Publisher postprint (380 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Anacardiaceae; Antiplasmodial activities; Antrocaryon klaineanum; Ergostane steroids
Abstract :
[en] During a study on the chemistry and biological activity of Antrocaryon klaineanum Pierre, six new sterols including 4,24(28)-ergostadiene-6alpha,7alpha-diol (1), 6alpha-methoxy-4,24(28)-ergostadiene-7alpha,20S-diol (2), 6alpha-methoxy-4,24(28)-ergostadien-7alpha-ol (3), 20S-hydroxy-24(28)-ergosten-3-one (4), 7alpha-hydroxy-4,24(28)-ergostadien-3-one (5), and 24(28)-ergostene-3beta,6alpha-diol (6) were characterized by physical and spectroscopic means. The known steroids 7 and 8 were also isolated. The crude extract and the isolated compounds were evaluated for their ability to inhibit the 3D7 strain of Plasmodium falciparum. Compounds 2, 3, and 8 showed potent activity while that of the crude extract was moderate.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Douanla, Pascal D.
Tabopda, Turibio Kuiate
Tchinda, Alembert T.
Cieckiewicz, Ewa ;  Université de Liège > Département de pharmacie > Pharmacognosie
Frederich, Michel  ;  Université de Liège - ULiège
Boyom, Fabrice Fekam
Tsabang, Nole
Yeboah, Samuel
Nkengfack, Augustin E.
Tchuendem, Marguerite Hortence K.
Language :
English
Title :
Antrocarines A-F, antiplasmodial ergostane steroids from the stem bark of Antrocaryon klaineanum.
Publication date :
2015
Journal title :
Phytochemistry
ISSN :
0031-9422
eISSN :
1873-3700
Publisher :
Elsevier, Netherlands
Volume :
117
Pages :
521-6
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2015 Elsevier Ltd. All rights reserved.
Available on ORBi :
since 13 October 2015

Statistics


Number of views
84 (3 by ULiège)
Number of downloads
3 (1 by ULiège)

Scopus citations®
 
13
Scopus citations®
without self-citations
11
OpenCitations
 
9

Bibliography


Similar publications



Contact ORBi