Antrocarines A-F, antiplasmodial ergostane steroids from the stem bark of Antrocaryon klaineanum.

[en] During a study on the chemistry and biological activity of Antrocaryon klaineanum Pierre, six new sterols including 4,24(28)-ergostadiene-6alpha,7alpha-diol (1), 6alpha-methoxy-4,24(28)-ergostadiene-7alpha,20S-diol (2), 6alpha-methoxy-4,24(28)-ergostadien-7alpha-ol (3), 20S-hydroxy-24(28)-ergosten-3-one (4), 7alpha-hydroxy-4,24(28)-ergostadien-3-one (5), and 24(28)-ergostene-3beta,6alpha-diol (6) were characterized by physical and spectroscopic means. The known steroids 7 and 8 were also isolated. The crude extract and the isolated compounds were evaluated for their ability to inhibit the 3D7 strain of Plasmodium falciparum. Compounds 2, 3, and 8 showed potent activity while that of the crude extract was moderate.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Douanla, Pascal D.

Tabopda, Turibio Kuiate

Tchinda, Alembert T.

Cieckiewicz, Ewa ; Université de Liège > Département de pharmacie > Pharmacognosie

Frederich, Michel ; Université de Liège - ULiège

Boyom, Fabrice Fekam

Tsabang, Nole

Yeboah, Samuel

Nkengfack, Augustin E.

Tchuendem, Marguerite Hortence K.

Language :

English

Title :

Antrocarines A-F, antiplasmodial ergostane steroids from the stem bark of Antrocaryon klaineanum.

Publication date :

2015

Journal title :

Phytochemistry

ISSN :

0031-9422

eISSN :

1873-3700

Publisher :

Elsevier, Netherlands

Volume :

117

Pages :

521-6

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 13 October 2015

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