Reference : Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine.
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/199345
Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine.
English
Frederich, Michel mailto [Université de Liège > Département de pharmacie > Pharmacognosie >]
Pirotte, Bernard mailto [Université de Liège > Département de pharmacie > Chimie pharmaceutique >]
Fillet, Marianne mailto [Université de Liège > Département de pharmacie > Analyse des médicaments >]
De Tullio, Pascal mailto [Université de Liège > Département de pharmacie > Chimie pharmaceutique >]
2016
Journal of Medicinal Chemistry
American Chemical Society
59
19
8649–8666
Yes (verified by ORBi)
International
0022-2623
1520-4804
Washington
DC
[en] "Omics" sciences have been developed to provide a holistic point of view of biology and to better understand the complexity of an organism as a whole. These systems biology approaches can be examined at different levels, starting from the most fundamental, i.e., the genome, and finishing with the most functional, i.e., the metabolome. Similar to how genomics is applied to the exploration of DNA, metabolomics is the qualitative and quantitative study of metabolites. This emerging field is clearly linked to genomics, transcriptomics, and proteomics. In addition, metabolomics provides a unique and direct vision of the functional outcome of an organism's activities that are required for it to survive, grow, and respond to internal and external stimuli or stress, e.g., pathologies and drugs. The links between metabolic changes, patient phenotype, physiological and/or pathological status, and treatment are now well established and have opened a new area for the application of metabolomics in the drug discovery process and in personalized medicine.
http://hdl.handle.net/2268/199345
10.1021/acs.jmedchem.5b01335

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