17-O-Acetyl,10-hydroxycorynantheol, a Selective Antiplasmodial Alkaloid Isolated from Strychnos usambarensis Leaves

[en] In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary indolic alkaloid has been isolated: 17-O-acetyl, 10-hydroxycorynantheol 1. Its structure was determined by means of spectroscopic and spectrometric methods such as UV, IR, CD, NMR and ESI-MS. 17-O-acetyl, 10-hydroxycorynantheol 1 is one of the most active monomeric indole alkaloid known to date showing an in vitro activity against Plasmodium falciparum close to 5 µM and a high selectivity.

Research Center/Unit :

CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Cao, Martine ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Muganga, Raymond ; Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)

Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie

Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie

Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Language :

English

Title :

17-O-Acetyl,10-hydroxycorynantheol, a Selective Antiplasmodial Alkaloid Isolated from Strychnos usambarensis Leaves

Publication date :

August 2011

Journal title :

Planta Medica

ISSN :

0032-0943

eISSN :

1439-0221

Publisher :

Georg Thieme Verlag Stuttgart, New York, United States - New York

Volume :

Pages :

2050-2053

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 October 2011

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