Reference : Netamines H-N, Tricyclic Alkaloids from the Marine Sponge Biemna laboutei and Their A...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/168654
Netamines H-N, Tricyclic Alkaloids from the Marine Sponge Biemna laboutei and Their Antimalarial Activity.
English
Gros, Emmanuelle [> >]
Al-Mourabit, Ali [> >]
Martin, Marie-Therese [> >]
Sorres, Jonathan [> >]
Vacelet, Jean [> >]
Frederich, Michel mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
Aknin, Maurice [> >]
Kashman, Yoel [> >]
Gauvin-Bialecki, Anne [> >]
Apr-2014
Journal of Natural Products
77
4
818-23
Yes (verified by ORBi)
International
0163-3864
1520-6025
United States
[en] Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 muM.
http://hdl.handle.net/2268/168654
10.1021/np4009283

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
np4009283.pdfPublisher postprint273.58 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.