Article (Scientific journals)
New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots
Frederich, Michel; De Pauw-Gillet, Marie-Claire; Llabres, Gabriel et al.
2000In Planta Medica, 66 (3), p. 262-9
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Keywords :
indolomonoterpenoid; indole alkaloid; antiplasmodial; bisindolic; malaria; plasmodium falciparum
Abstract :
[en] Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy-isosungucine (10). They were identified by detailed spectroscopic methods. The complete 1H- and 13C-NMR study of sungucine was also realized. Some of these compounds were highly active against Plasmodium falciparum in vitro and more particularly against the chloroquine-resistant strain. Compound 10 showed a selective antiplasmodial activity, with > 100-fold greater toxicity towards Plasmodium falciparum, relative to cultured human cancer cells (KB and HeLa lines) or fibroblasts (WI38).
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
De Pauw-Gillet, Marie-Claire ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques
Llabres, Gabriel ;  Université de Liège - ULiège > Département de physique > Département de physique
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Hayette, Marie-Pierre ;  Université de Liège - ULiège > Microbiologie médicale
Brandt, Viviane
Penelle, Jacques
De Mol, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots
Publication date :
April 2000
Journal title :
Planta Medica
ISSN :
0032-0943
eISSN :
1439-0221
Publisher :
Georg Thieme Verlag, Germany
Volume :
66
Issue :
3
Pages :
262-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 February 2009

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