New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots

[en] Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy-isosungucine (10). They were identified by detailed spectroscopic methods. The complete 1H- and 13C-NMR study of sungucine was also realized. Some of these compounds were highly active against Plasmodium falciparum in vitro and more particularly against the chloroquine-resistant strain. Compound 10 showed a selective antiplasmodial activity, with > 100-fold greater toxicity towards Plasmodium falciparum, relative to cultured human cancer cells (KB and HeLa lines) or fibroblasts (WI38).

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

De Pauw-Gillet, Marie-Claire ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques

Llabres, Gabriel ; Université de Liège - ULiège > Département de physique > Département de physique

Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie

Hayette, Marie-Pierre ; Université de Liège - ULiège > Microbiologie médicale

Brandt, Viviane

Penelle, Jacques

De Mol, Patrick ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale

Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Language :

English

Title :

New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots

Publication date :

April 2000

Journal title :

Planta Medica

ISSN :

0032-0943

eISSN :

1439-0221

Publisher :

Georg Thieme Verlag, Germany

Volume :

Issue :

Pages :

262-9

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 February 2009

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Bibliography

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