Article (Scientific journals)
Chemical and biological investigations of a toxic plant from Central Africa, Magnistipula butayei subsp montana
Karangwa, Charles; Esters, Virginie; Frederich, Michel et al.
2006In Journal of Ethnopharmacology, 103 (3), p. 433-438
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Keywords :
Magnistipula butayei subsp montana; Chrysobalanaceae; convulsions; acute toxicity; hypothermia; blood parameters
Abstract :
[en] Magnistipida butayei subsp. montana (Chrysobalanaceae) is known, in the Great Lakes Region, to possess toxicological properties. In this paper, we investigated the acute toxicity (dose levels 50-1600 mg/kg) of its aqueous extract, administered orally to adult Wistar rats. This study demonstrated that the freeze-dried aqueous extract (5%, w/w) possesses high toxicity. The extract caused hypothermia, neurological disorders, including extensor reflex of maximal convulsive induced-seizures at about 2h after the administered dose, and death occurred (LD50 = 370 mg/kg) in a dose dependent manner. Blood parameter evaluation revealed slight variations, but these might not have clinical relevance. Histological examination of internal organs (lungs, liver, heart and kidneys) did not reveal any abnormality in the treated group compared to the control. Therefore, it can be concluded that Magnistipida butayei subsp. montana aqueous extract, given orally, is toxic and that its target is the central nervous system. General phytochemical screening revealed that the plant did not contain significant amounts of products known to be toxic, such as alkaloids or cardioactive glycosides, but only catechic tannins, amino acids, saponins and other aphrogen principles in the three parts of the species (fruit, leave and bark). (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Research center :
Centre Interfacultaire de Recherche du Médicament (C.I.R.M.)
Disciplines :
Pharmacy, pharmacology & toxicology
Chemistry
Phytobiology (plant sciences, forestry, mycology...)
Author, co-author :
Karangwa, Charles;  Université Nationale du Rwanda - UNR > Pharmacie
Esters, Virginie ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Frederich, Michel  ;  Université de Liège - ULiège > Pharmacie > Pharmacognosie
Tits, Monique ;  Université de Liège - ULiège > Pharmacie > Pharmacognosie
Kadima, Justin N.;  Université Nationale du Rwanda - UNR > Pharmacie
Damas, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Noirfalise, Alfred ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Chemical and biological investigations of a toxic plant from Central Africa, Magnistipula butayei subsp montana
Publication date :
February 2006
Journal title :
Journal of Ethnopharmacology
ISSN :
0378-8741
eISSN :
1872-7573
Publisher :
Elsevier Ireland Ltd, Clare, Ireland
Volume :
103
Issue :
3
Pages :
433-438
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 October 2009

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