PHARMACOLOGICAL ASSESSMENT OF CONSTITUENTS OF SPECIES ALLIUM SAXATILE AND ALLIUM PONTICUM GROWING IN GEORGIA

The present study aimed to estimate the pharmacological potency of products from some Allium species - Allium saxatile and Allium ponticum, growing in Georgia. Analgesic, anti-inflammatory and gastroprotective activity of total extracts and fractions were evaluated using accepted in vivo models: hot-plate, carrageenan-induced edema and ethanol-induced gastric ulcer, respectively. The results of the experiments have revealed valuable effects of the total extracts and fractions obtained from A. saxatile and A. ponticum. In particular, A. saxatile total extract demonstrated moderately ascending prolonged analgesic activity (70.3%), whereas total extract of A.ponticum exhibited rapid, high, but short-lasting effect (105%). The same tendency was noticed when fractions were studied. Similarly, A. saxatile total extract and its fractions appeared more effective (63.5%), than one obtained from A.ponticum (32.7%) in the carrageenan-induced paw oedema model. In the ethanol-induced gastric ulcer model, only A. saxatile appeared to effectively reduce ulcer index (UI) by 44%, when A. ponticum extract, oppositely, increased ulcer index (UI). Summarizing the results, it can be concluded that the study revealed A.saxatile and A.ponticum as promising raw of bioactive compounds for drug development.