Anti-inflammatory and antioxidant activities of Rungia congoensis, a traditional vegetable consumed by Yombe people from Kongo Central area (DR. Congo).
Mutwale Kapepula, Paulin; Baku Ngumbi, Pacha; Kasongo Kawayidiko, Michelet al.
Anti inflammatory and antioxidant activities of Rungia congoensis a traditional vegetable consumed by Yombe people from Kongo Central area DR Congo.pdf
Microscopic character; Rungia congoensis; myeloperoxidase; pharmacognostic study; traditional food
Abstract :
[en] Rungia congoensis, a traditional vegetable from Kongo Central area (DR. Congo) was studied for establishing microscopic characters and characterised by chromatographic techniques and their in vitro biochemical activities against ROS production were evaluated in cellular models and on an enzyme, myeloperoxidase (MPO), involved in inflammation. Microscopically leaf can be characterised by non-glandular and glandular trichomes, sinuous anticlinal epidermal cells, diacytic stomata and helical vessels. Methanolic extract displayed high cellular antioxidant activity at the concentrations range of 0.1-10 mug mL(-1) and 1-20 mug mL(-1) using lucigenin on neutrophils and DCFH-DA on HL 60, respectively. This extract also showed, more efficient effects on extracellular and intracellular ROS production and MPO activity. Antioxidant and anti-inflammatory activities of R. congoensis were significantly higher, positively correlated with their phytochemical constituents such as flavonoids, iridoids and phenolic acids; and could justify their use as traditional vegetable and potent local nutraceutical resource.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Mutwale Kapepula, Paulin
Baku Ngumbi, Pacha
Kasongo Kawayidiko, Michel
Duki Mpanzu, Arthur
Franck, Thierry ; Université de Liège - ULiège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Mouithys-Mickalad, Ange ; Université de Liège - ULiège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Ngombe Kabamba, Nadege
Masiala Tsobo, Christophe
Language :
English
Title :
Anti-inflammatory and antioxidant activities of Rungia congoensis, a traditional vegetable consumed by Yombe people from Kongo Central area (DR. Congo).
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