In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja

Reference : In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from St...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology Physical, chemical, mathematical & earth Sciences : Chemistry Life sciences : Phytobiology (plant sciences, forestry, mycology...)
	To cite this reference:	http://hdl.handle.net/2268/8943

Title :	In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja
Language :	English
Author, co-author :	Philippe, Geneviève [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
	De Mol, Patrick [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale]
	Angenot, Luc [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
	Tits, Monique [Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie >]
	Frederich, Michel [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
Publication date :	May-2007
Journal title :	Planta Medica
Publisher :	Georg Thieme Verlag Kg
Volume :	73
Issue/season :	5
Pages :	478-479
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0032-0943
City :	Stuttgart
Keywords :	[en] indolomonoterpenoid ; indole alkaloid ; strychnos ; antiplasmodial activity ; Plasmodium falciparum ; antimalarial
Abstract :	[en] Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja. The in vivo antimalarial activity against the P. vinckei petteri murine strain was determined. In the Peters 4-day suppressive test, 1 suppressed the parasitemia by almost 50 percent on day 4 at the dose of 30 mg/kg by intraperitoneal route.
Permalink :	http://hdl.handle.net/2268/8943
DOI :	10.1055/s-2007-967174

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