In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja

[en] Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja. The in vivo antimalarial activity against the P. vinckei petteri murine strain was determined. In the Peters 4-day suppressive test, 1 suppressed the parasitemia by almost 50 percent on day 4 at the dose of 30 mg/kg by intraperitoneal route.

Disciplines :

Pharmacy, pharmacology & toxicology
Chemistry
Phytobiology (plant sciences, forestry, mycology...)

Author, co-author :

Philippe, Geneviève ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

De Mol, Patrick ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale

Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie

Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Language :

English

Title :

In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja

Publication date :

May 2007

Journal title :

Planta Medica

ISSN :

0032-0943

eISSN :

1439-0221

Publisher :

Georg Thieme Verlag Kg, Stuttgart, Germany

Volume :

Issue :

Pages :

478-479

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 March 2009

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