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Article (Scientific journals)
In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja
Philippe, Geneviève  ; De Mol, Patrick  ; Angenot, Luc  et al.
2007 • In Planta Medica, 73 (5), p. 478-479
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Keywords :
indolomonoterpenoid; indole alkaloid; strychnos; antiplasmodial activity; Plasmodium falciparum; antimalarial
Abstract :
[en] Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja. The in vivo antimalarial activity against the P. vinckei petteri murine strain was determined. In the Peters 4-day suppressive test, 1 suppressed the parasitemia by almost 50 percent on day 4 at the dose of 30 mg/kg by intraperitoneal route.
Disciplines :
Pharmacy, pharmacology & toxicology
Chemistry
Phytobiology (plant sciences, forestry, mycology...)
Author, co-author :
Philippe, Geneviève ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
De Mol, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja
Publication date :
May 2007
Journal title :
Planta Medica
ISSN :
0032-0943
eISSN :
1439-0221
Publisher :
Georg Thieme Verlag Kg, Stuttgart, Germany
Volume :
73
Issue :
5
Pages :
478-479
Peer reviewed :
Peer Reviewed verified by ORBi

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