Reference : Unguiculin A and Ptilomycalins E-H, Antimalarial Guanidine Alkaloids from the Marine ...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/211700
Unguiculin A and Ptilomycalins E-H, Antimalarial Guanidine Alkaloids from the Marine Sponge Monanchora unguiculata.
English
Campos, Pierre-Eric [Université de La Réunion > Faculté des Sciences et Technologies > Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments > docteur >]
Wolfender, Jean-Luc [University of lausanne > EPGL > school of pharmaceutical sciences > >]
Quieroz, Emerson F. [unversity of lausanne > EPGL > school of pharmaceutical sciences > >]
Marcourt, Laurence [university of lausanne > EPGL > School of pharmaceutical Sicences > >]
Al-Mourabit, Ali [Université Paris-Sud 11 > CNRS UPR 2301 > Institut de chimie des substances naturelles > >]
Frederich, Michel mailto [Université de Liège > Département de pharmacie > Pharmacognosie >]
Bordignon, Annélise mailto [Université de Liège > Département de pharmacie > Pharmacognosie >]
De Voogd, Nicole [Naturalis Biodiversity Center > > > >]
Illien, Bertrand [Université de La réunion > fFaculté des scicences et technologies > Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments > >]
Gauvin-Bialeki, Anne [Université de la Réunion > Faculté des Sciences et Technologies > Laboratoire des Substances Naturelles et des Sciences des Aliments > >]
10-Apr-2017
Journal of Natural Products
American Chemical Society
80
1404-1410
Yes (verified by ORBi)
International
0163-3864
1520-6025
Washington
DC
[en] Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge Monanchora unguiculata collected in Madagascar highlighted five new compounds, one acyclic guanidine alkaloid, unguiculin A (1) and four pentacyclic alkaloids, ptilomycalins E-H (2-5), along with four known compounds: crambescidin 800 (6) and crambescidin 359 (7), crambescidic acid (8), and fromiamycalin (9). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. The new ptilomycalin E (2) and the mixture of the new ptilomycalins G (4) and H (5) showed promising cytotoxicity against KB cells with IC50 values of 0.85 and 0.92 μM, respectively. Ptilomycalin F (3) and fromiamycalin (9) exhibited promising activity against Plasmodium falciparum with IC50 values of 0.23 and 0.24 μM, respectively
L.C.S.N.S.A
European Commission and the Regional Concil of Reunion Island
BIOMOL-TCN
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/211700
10.1021/acs.jnatprod.6b01079
http://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.6b01079

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