Article (Scientific journals)
Antileishmanial and cytotoxic activities of a new limonoid and a new phenyl alkene from the stem bark of Trichilia gilgiana (Meliaceae)
Kowa, Theodora K.; Tchokouaha, Lauve R. Y.; Cieckiewicz, Ewa et al.
2019In Natural Product Research, 0 (0), p. 1-7
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Abstract :
[en] AbstractOne new limonoid, trigilgianin (1), one new phenyl alkene, epoxy gilgialkene (2), together with five known compounds: scopoletin (3), sitosteryl-6’-O-undecanoate-β-D-glucoside (4), sitosteryl-O-β-D-glucopyranoside (5), cinchonain A (6) and cinchonain B (7) were isolated from the stem bark of Trichilia gilgiana Harms. (Meliaceae). All compounds were isolated for the first time from this species. The structures were elucidated on the basis of spectral studies and by comparison of these data with those from the literature. Compounds 1, 2, 3, 6 and 7 were tested for in vitro antileishmanial activity against visceral leishmaniasis parasite Leishmania donovani and cytotoxicity against macrophage RAW 264.7 cell line. Compounds 1 and 3 showed the highest antileishmanial activity (IC50 values of 6.044 and 6.804 µg/mL, respectively) with low cytotoxicity (CC50 values of >200 and 47.47 µg/mL, respectively), while compound 2 was moderately active on L. donovani promastigotes (IC50 56.81 µg/mL).
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Kowa, Theodora K.
Tchokouaha, Lauve R. Y.
Cieckiewicz, Ewa ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Philips, Trudy Janice
Dotse, Eunice
Wabo, Hippolyte K.
Tchinda, Alembert T.
Tane, Pierre
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Antileishmanial and cytotoxic activities of a new limonoid and a new phenyl alkene from the stem bark of Trichilia gilgiana (Meliaceae)
Publication date :
2019
Journal title :
Natural Product Research
ISSN :
1478-6419
eISSN :
1478-6427
Publisher :
Taylor & Francis
Volume :
0
Issue :
0
Pages :
1-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 January 2019

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