Article (Scientific journals)
Flavonoid Analysis and Antioxidant Activities of the Bryonia alba L. Aerial Parts
Ielciu, Irina; Frederich, Michel; Hanganu, Daniela et al.
2019In Antioxidants, 8 (4 108)
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Abstract :
[en] Bryonia alba L. is the only Bryonia species found in Romanian flora, being known as a remedy for inflammatory pathologies or for its hepatoprotective and adaptogen activities. The present investigation studied the flavonoid composition and antioxidant activities of the aerial parts of this species. Flavonoid profile was evaluated by HPLC coupled with Diode Array Detection (DAD), while antioxidant capacity was assessed by various methods, testing different antioxidant mechanisms: DPPH (2,2-diphenyl-1-picrylhydrazyl), CUPRAC (cupric reducing antioxidant capacity), FRAP (ferric reducing ability of plasma), TEAC (Trolox equivalent antioxidant capacity), EPR (electron paramagnetic resonance method) and SNPAC (silver nanoparticles antioxidant capacity). Cytotoxicity was tested on human cancerous and healthy cell lines. Anti-plasmodial tests were performed on two strains of Plasmodium falciparum. Whole organism toxicity was assessed on zebrafish larvae. The HPLC-DAD analysis proved the presence of lutonarin, saponarin, isoorientin, and isovitexin as the major flavonoids in the composition of tested samples. Significant results were obtained for all antioxidant capacity assays. The cytotoxicity tests proved the absence of cellular and parasitic toxicity and these results were confirmed by the lack of toxicity on the zebrafish larvae model. This study proves a promising potential of the aerial parts of Bryonia alba L. as antioxidant agents.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Ielciu, Irina
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Hanganu, Daniela
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Olah, Neli-Kinga
Ledoux, Allison ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Crișan, Gianina
Păltinean, Ramona
Language :
English
Title :
Flavonoid Analysis and Antioxidant Activities of the Bryonia alba L. Aerial Parts
Publication date :
2019
Journal title :
Antioxidants
eISSN :
2076-3921
Publisher :
MDPI AG, Switzerland
Volume :
8
Issue :
4 108
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 April 2019

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