Reference : New Antimalarial and Antimicrobial Tryptamine Derivatives from the Marine Sponge Fasc...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/234216
New Antimalarial and Antimicrobial Tryptamine Derivatives from the Marine Sponge Fascaplysinopsis reticulata
English
Campos, P.-E. [Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences et Technologies, Université de La Réunion, La Réunion, 15 Avenue René Cassin, 97744 Saint-Denis CEDEX 9, France]
Pichon, E. [Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences et Technologies, Université de La Réunion, La Réunion, 15 Avenue René Cassin, 97744 Saint-Denis CEDEX 9, France]
Moriou, C. [Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay ,av. de la Terrasse, Gif-sur-Yvette, 91198, France]
Clerc, P. [Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences et Technologies, Université de La Réunion, La Réunion, 15 Avenue René Cassin, 97744 Saint-Denis CEDEX 9, France]
Trépos, R. [Laboratoire des Sciences de l'Environnement MARin (LEMAR), Université de Brest, CNRS, IRD, Ifremer, LEMAR, Plouzane, F-29280, France]
Frederich, Michel mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
De Voogd, N. [Naturalis Biodiversity Center, Darwinweg 2, CR Leiden, 2333, Netherlands]
Hellio, C. [Laboratoire des Sciences de l'Environnement MARin (LEMAR), Université de Brest, CNRS, IRD, Ifremer, LEMAR, Plouzane, F-29280, France]
Gauvin-Bialecki, A. [Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences et Technologies, Université de La Réunion, La Réunion, 15 Avenue René Cassin, 97744 Saint-Denis CEDEX 9, France]
Al-Mourabit, A. [Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay ,av. de la Terrasse, Gif-sur-Yvette, 91198, France]
2019
Marine Drugs
NLM (Medline)
17
3
167
Yes (verified by ORBi)
International
16603397
[en] Fascaplysinopsis reticulata
[en] Chemical study of the CH₂Cl₂-MeOH (1:1) extract of the sponge Fascaplysinopsis reticulata collected in Mayotte highlighted three new tryptophan derived alkaloids, 6,6'-bis-(debromo)-gelliusine F (1), 6-bromo-8,1'-dihydro-isoplysin A (2) and 5,6-dibromo-8,1'-dihydro-isoplysin A (3), along with the synthetically known 8-oxo-tryptamine (4) and the three known molecules from the same family, tryptamine (5), (E)-6-bromo-2'-demethyl-3'-N-methylaplysinopsin (6) and (Z)-6-bromo-2'-demethyl-3'-N-methylaplysinopsin (7). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their antimicrobial and their antiplasmodial activities. Regarding antimicrobial activities, the best compounds are (2) and (3), with minimum inhibitory concentration (MIC) of 0.01 and 1 µg/mL, respectively, towards Vibrio natrigens, and (5), with MIC values of 1 µg/mL towards Vibrio carchariae. In addition the known 8-oxo-tryptamine (4) and the mixture of the (E)-6-bromo-2'-demethyl-3'-N-methylaplysinopsin (6) and (Z)-6-bromo-2'-demethyl-3'-N-methylaplysinopsin (7) showed moderate antiplasmodial activity against Plasmodium falciparum with IC50 values of 8.8 and 8.0 µg/mL, respectively.
http://hdl.handle.net/2268/234216
10.3390/md17030167

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