[en] An ethyl acetate extract of Psiadia arguta leaves showed in vitro antiplasmodial activity against Plasmodium falciparum with IC50 values of 12.3 +/- 2.4 mug/mL (3D7 strain) and 13.5 +/- 3.4 mug/mL (W2 strain). Phytochemical investigation led to the isolation and characterization of 16 compounds including four new diterpenoids: labdan-8alpha-ol-15-yl-(formate) (1), labdan-8alpha-ol-15-yl-(2-methylbutanoate) (2), labdan-8alpha-ol-15-yl-(3-methylpentanoate) (3), and labdan-8alpha-ol-15-yl-(labdanolate) (4). The latter compounds were characterized by spectroscopic methods (1D and 2D NMR, HRMS, and IR). The in vitro antiplasmodial activities of all compounds were evaluated. The known compounds labdan-13( E)-en-8alpha-ol-15-yl acetate (5), labdan-8alpha-ol-15-yl acetate (6), 13- epi-sclareol (7), labdan-13( E)-ene-8alpha,15-diol (8), and (8 R,13 S)-labdane-8alpha,15-diol (9) exhibited antiplasmodial effects, with IC50 values of 29.1, 33.2, 35.0, 36.6, and 22.2 muM, respectively.
Disciplines :
Pharmacie, pharmacologie & toxicologie
Auteur, co-auteur :
Mahadeo, Keshika
Herbette, Gaetan
Grondin, Isabelle
Jansen, Olivia ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Kodja, Hippolyte
Soulange, Joyce
Jhaumeer-Laulloo, Sabina
Clerc, Patricia
Gauvin-Bialecki, Anne
Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Langue du document :
Anglais
Titre :
Antiplasmodial Diterpenoids from Psiadia arguta.
Date de publication/diffusion :
2019
Titre du périodique :
Journal of Natural Products
ISSN :
0163-3864
eISSN :
1520-6025
Maison d'édition :
American Chemical Society (ACS), Washington, Etats-Unis - District de Columbia
Bosser, J.; Guého, J.; Jeffrey, C. In Flore Des Mascareignes. La Réunion, Maurice, Rodrigues; The Sugar Industry Research Institute, Mauritius, L'Institut Français de Recherche Scientifique pour le Développement en Coopération (ORSTOM); Paris, The Royal Botanic Gardens, Kew, 1993.
Sussman, L. K. J. Ethnopharmacol. 1980, 2, 259-278, 10.1016/S0378-8741(80)81005-1
Wang, Y.; Hamburger, M.; Gueho, J.; Hostettmann, K. Helv. Chim. Acta 1992, 75, 269-275, 10.1002/hlca.19920750122
Kauroo, S.; Govinden-Soulange, J.; Marie, D. E. P. Int. J. Chem. Environ. Biol. Sci. 2016, 4, 23-27
Recio, M. C.; Giner, R. M.; Mánez, S.; Rios, J. L.; Marston, A.; Hostettmann, K. Phytother. Res. 1995, 9, 571-574, 10.1002/ptr.2650090807
Jonville, M. C.; Kodja, H.; Strasberg, D.; Pichette, A.; Ollivier, E.; Frédérich, M.; Angenot, L.; Legault, J. J. Ethnopharmacol. 2011, 136, 525-531, 10.1016/j.jep.2010.06.013
Dias, M. O.; Hamerski, L.; Pinto, A. C. Quim. Nova 2011, 34, 704-706, 10.1590/S0100-40422011000400026
Urones, J. G.; Marcos, I. S.; Cubillo, L.; Monje, V. A.; Hernández, J. M.; Basabe, P. Phytochemistry 1989, 28, 651-653, 10.1016/0031-9422(89)80077-9
Urones, J. G.; Basabe, P.; Marcos, I. S.; Díez Martín, D.; Sexmero, M. J.; Peral, M. H.; Broughton, H. B. Tetrahedron 1992, 48, 10389-10398, 10.1016/S0040-4020(01)88343-5
