Reference : Antiplasmodial Diterpenoids from Psiadia arguta.
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/234502
Antiplasmodial Diterpenoids from Psiadia arguta.
English
Mahadeo, Keshika [> >]
Herbette, Gaetan [> >]
Grondin, Isabelle [> >]
Jansen, Olivia mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
Kodja, Hippolyte [> >]
Soulange, Joyce [> >]
Jhaumeer-Laulloo, Sabina [> >]
Clerc, Patricia [> >]
Gauvin-Bialecki, Anne [> >]
Frederich, Michel mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
2019
Journal of natural products
Yes (verified by ORBi)
International
0163-3864
1520-6025
United States
[en] An ethyl acetate extract of Psiadia arguta leaves showed in vitro antiplasmodial activity against Plasmodium falciparum with IC50 values of 12.3 +/- 2.4 mug/mL (3D7 strain) and 13.5 +/- 3.4 mug/mL (W2 strain). Phytochemical investigation led to the isolation and characterization of 16 compounds including four new diterpenoids: labdan-8alpha-ol-15-yl-(formate) (1), labdan-8alpha-ol-15-yl-(2-methylbutanoate) (2), labdan-8alpha-ol-15-yl-(3-methylpentanoate) (3), and labdan-8alpha-ol-15-yl-(labdanolate) (4). The latter compounds were characterized by spectroscopic methods (1D and 2D NMR, HRMS, and IR). The in vitro antiplasmodial activities of all compounds were evaluated. The known compounds labdan-13( E)-en-8alpha-ol-15-yl acetate (5), labdan-8alpha-ol-15-yl acetate (6), 13- epi-sclareol (7), labdan-13( E)-ene-8alpha,15-diol (8), and (8 R,13 S)-labdane-8alpha,15-diol (9) exhibited antiplasmodial effects, with IC50 values of 29.1, 33.2, 35.0, 36.6, and 22.2 muM, respectively.
http://hdl.handle.net/2268/234502
10.1021/acs.jnatprod.8b00698

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