Article (Scientific journals)
Antiplasmodial Diterpenoids from Psiadia arguta.
Mahadeo, Keshika; Herbette, Gaetan; Grondin, Isabelle et al.
2019In Journal of Natural Products, 82 (5), p. 1261-1266
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Abstract :
[en] An ethyl acetate extract of Psiadia arguta leaves showed in vitro antiplasmodial activity against Plasmodium falciparum with IC50 values of 12.3 +/- 2.4 mug/mL (3D7 strain) and 13.5 +/- 3.4 mug/mL (W2 strain). Phytochemical investigation led to the isolation and characterization of 16 compounds including four new diterpenoids: labdan-8alpha-ol-15-yl-(formate) (1), labdan-8alpha-ol-15-yl-(2-methylbutanoate) (2), labdan-8alpha-ol-15-yl-(3-methylpentanoate) (3), and labdan-8alpha-ol-15-yl-(labdanolate) (4). The latter compounds were characterized by spectroscopic methods (1D and 2D NMR, HRMS, and IR). The in vitro antiplasmodial activities of all compounds were evaluated. The known compounds labdan-13( E)-en-8alpha-ol-15-yl acetate (5), labdan-8alpha-ol-15-yl acetate (6), 13- epi-sclareol (7), labdan-13( E)-ene-8alpha,15-diol (8), and (8 R,13 S)-labdane-8alpha,15-diol (9) exhibited antiplasmodial effects, with IC50 values of 29.1, 33.2, 35.0, 36.6, and 22.2 muM, respectively.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Mahadeo, Keshika
Herbette, Gaetan
Grondin, Isabelle
Jansen, Olivia ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Kodja, Hippolyte
Soulange, Joyce
Jhaumeer-Laulloo, Sabina
Clerc, Patricia
Gauvin-Bialecki, Anne
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Antiplasmodial Diterpenoids from Psiadia arguta.
Publication date :
2019
Journal title :
Journal of Natural Products
ISSN :
0163-3864
eISSN :
1520-6025
Publisher :
American Chemical Society, Washington, United States - District of Columbia
Volume :
82
Issue :
5
Pages :
1261-1266
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 April 2019

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