[en] Evaluation of analytical results reliability is of core importance as crucial decisions
are taken with them. From the various methodologies to evaluate the fitness of
purpose of analytical methods, overall measurement uncertainty estimation is more
and more applied. Overall measurement uncertainty allows to combine
simultaneously the remaining systematic influences to the random sources of
uncertainty and allows assessing the reliability of results generated by analytical
methods. However there are various interpretations on how to estimate overall
measurement uncertainty, and thus various models for estimating it. Each model
together with its assumptions has great impacts on the risks to abusively declare that
analytical methods are suitable for their intended purpose. This review paper aims at
i) summarizing the various models used to estimate overall measurement uncertainty,
ii) provide their pros and cons, iii) review the main areas of application and iv) as a
conclusion provide some recommendations when evaluating overall measurement
uncertainty.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Rozet, Eric ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
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