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Profil

Boulanger Bruno

Département de pharmacie

Chimie analytique

See author's contact details
Main Referenced Co-authors
Hubert, Philippe  (178)
Rozet, Eric  (75)
Chiap, Patrice  (72)
Dewe, Walthere  (65)
Crommen, Jacques  (59)
Main Referenced Keywords
Validation (11); Design Space (9); validation (9); accuracy profile (8); Design space (7);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] (12)
C.I.R.M. (4)
Centre Interfacultaire de Recherche du Médicament - CIRM (4)
C.R.I.M. (1)
Centre Interfacultaire de Recherche du Médicament (1)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (161)
Chemistry (25)
Mathematics (11)
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others (8)
Computer science (1)

Publications (total 187)

The most downloaded
2642 downloads
Dispas, A., Lebrun, P., Mbinze Kindenge, J., Debrus, B., Mavar Tayer Mbay, J., Boulanger, B., Marini Djang'Eing'A, R., & Hubert, P. (December 2011). Application d'une nouvelle méthode de développement de méthodes chromatographiques pour lutter contre la contrefaçon des médicaments anti-inflammatoires [Paper presentation]. Chimiométrie 2011, Marseille, France. https://hdl.handle.net/2268/104112

The most cited

410 citations (Scopus®)

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivet, C., & Valat, L. (15 November 2004). Harmonization of strategies for the validation of quantitative analytical procedures - A SFSTP proposal - part I. Journal of Pharmaceutical and Biomedical Analysis, 36 (3), 579-586. doi:10.1016/j.jpba.2004.07.027 https://hdl.handle.net/2268/6169

Van Laethem, T., Kumari, P., Boulanger, B., Hubert, P., Fillet, M., Sacre, P.-Y., & Hubert, C. (28 November 2022). User-Driven Strategy for In Silico Screening of Reversed-Phase Liquid Chromatography Conditions for Known Pharmaceutical-Related Small Molecules. Molecules, 27 (23), 8306. doi:10.3390/molecules27238306
Peer Reviewed verified by ORBi

Fouarge, E., Monseur, A., Boulanger, B., Annoussamy, M., Seferian, A. M., De Lucia, S., Lilien, C., Thielemans, L., Paradis, K., Cowling, B. S., Freitag, C., Carlin, B. P., & Servais, L. (January 2021). Hierarchical Bayesian modelling of disease progression to inform clinical trial design in centronuclear myopathy. Orphanet Journal of Rare Diseases, 16 (1), 3. doi:10.1186/s13023-020-01663-7
Peer Reviewed verified by ORBi

Avohou, T. H., Lebrun, P., Rozet, E., & Boulanger, B. (2020). Bayesian methods in design and analysis of stability studies. In E. Lesaffre, G. Baio, ... B. Boulanger, Bayesian methods in pharmaceutical research (pp. 391-405). Boca Raton, United States: CRC Press.
Peer reviewed

Avohou, T. H., Hubert, C., Debrus, B., Lebrun, P., Rudaz, S., Boulanger, B., & Hubert, P. (2018). Statistical methods in Quality by Design approach to Liquid Chromatography method development. In S. Fekete & I. Molnar, Software-Assisted Method Development for Modeling High Performance Liquid Chromatography (pp. 109-150). London, United Kingdom: World Scientific Publishing. doi:10.1142/q0161
Peer reviewed

Hubert, C., Lebrun, P., Boulanger, B., & Hubert, P. (23 November 2017). Intégration de la validation dans le concept AQbD [Paper presentation]. AFSEP - "La validation dans l'incertitude, l'incertitude dans la validation : comment garder le sourire?", Paris, France.

Hubert, C., Lebrun, P., Boulanger, B., & Hubert, P. (11 May 2017). Cycle de vie des méthodes, vers une maîtrise intégrée des performances quantitatives [Paper presentation]. AFSEP - Comment garantir un résultat quantitatif ?, Lyon, France.

Ziemons, E., Hubert, C., Marini Djang'Eing'A, R., Rozet, E., Lebrun, P., Boulanger, B., & Hubert, P. (12 May 2015). Validation des méthodes analytiques: Approche basée sur l'erreur totale [Paper presentation]. Chimie Analytique et chimie des eaux, Mons, Belgium.

Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., Hubert, C., & Hubert, P. (22 January 2015). Design Space for Analytical Methods: Why ? What ? How ? [Paper presentation]. AFSEP - Innovation en développements de méthodes, Lyon, France.

Lebrun, P., Giacoletti, K., Scherder, T., Rozet, E., & Boulanger, B. (2015). A quality by design approach for longitudinal quality attributes. Journal of Biopharmaceutical Statistics, 25, 1-13. doi:10.1080/10543406.2014.979197
Peer Reviewed verified by ORBi

Rozet, E., Lebrun, P., Michiels, J.-F., Sondag, P., Scherder, T., & Boulanger, B. (2015). Analytical Procedure Validation and the Quality by Design Paradigm. Journal of Biopharmaceutical Statistics, 25, 1-9. doi:10.1080/10543406.2014.971176
Peer Reviewed verified by ORBi

Debrus, B., Lebrun, P., Rozet, E., Schofield, T., Mbinze Kindenge, J., Marini Djang'Eing'A, R., Rudaz, S., Boulanger, B., & Hubert, P. (2013). A New Method for Quality by Design Robust Optimization in Liquid Chromatography. LC-GC Europe.
Peer Reviewed verified by ORBi

Lebrun, P., Boulanger, B., Debrus, B., Lambert, P., & Hubert, P. (2013). A Bayesian Design Space for analytical methods based on multivariate models and predictions. Journal of Biopharmaceutical Statistics, 23, 1330–1351. doi:10.1080/10543406.2013.834922
Peer Reviewed verified by ORBi

Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Kalenda Tshilombo, N., Mavar Tayey Mbay, J., Schofield, T., Boulanger, B., Rozet, E., Hubert, P., & Marini Djang'Eing'A, R. (12 September 2012). APPLICATION OF AN INNOVATIVE DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT NONSTEROIDAL ANTIINFLAMMATORY DRUGS. Journal of Chromatography. A, 1263, 113-124. doi:10.1016/j.chroma.2012.09.038
Peer Reviewed verified by ORBi

Bouabidi, A., Talbi, M., Bourichi, H., Bouklouze, A., El Karbane, M., Boulanger, B., Hubert, P., & Rozet, E. (2012). Flexibility and Applicability of β-expectation tolerance interval approach to assess the fitness of purpose of pharmaceutical analytical methods. Drug Testing and Analysis, 4 (12), 1014-1027. doi:10.1002/dta.1345
Peer Reviewed verified by ORBi

Lebrun, P., Krier, F., Mantanus, J., Grohganz, H., Yang, M., Rozet, E., Boulanger, B., Evrard, B., Rantanen, J., & Hubert, P. (2012). Design space approach in the optimization of the spray-drying process. European Journal of Pharmaceutics and Biopharmaceutics, 80 (1), 226-234. doi:10.1016/j.ejpb.2011.09.014
Peer Reviewed verified by ORBi

Dispas, A., Lebrun, P., Mbinze Kindenge, J., Debrus, B., Mavar Tayer Mbay, J., Boulanger, B., Marini Djang'Eing'A, R., & Hubert, P. (December 2011). Application d'une nouvelle méthode de développement de méthodes chromatographiques pour lutter contre la contrefaçon des médicaments anti-inflammatoires [Paper presentation]. Chimiométrie 2011, Marseille, France.

Rozet, E., Marini Djang'Eing'A, R., Lebrun, P., Ziemons, E., Boulanger, B., & Hubert, P. (September 2011). A BAYESIAN PREDICTIVE PROBABILITY CRITERION TO ASSESS ANALYTICAL METHODS VALIDITY [Poster presentation]. Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy.

Debrus, B., Lebrun, P., Mbinze Kindenge, J., Lecomte, F., Ceccato, A., Caliaro, G., Mavar Tayey Mbay, J., Boulanger, B., Marini Djang'Eing'A, R., Rozet, E., & Hubert, P. (2011). Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space. Journal of Chromatography. A, 1218, 5205-5215. doi:10.1016/j.chroma.2011.05.102
Peer Reviewed verified by ORBi

Rozet, E., Rudaz, S., Marini Djang'Eing'A, R., Ziemons, E., Boulanger, B., & Hubert, P. (2011). Models to estimate overall analytical measurements uncertainty: assumptions, comparisons and applications. Analytica Chimica Acta, 702, 160-171. doi:10.1016/j.aca.2011.06.055
Peer Reviewed verified by ORBi

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Rozet, E., Nistor, I., Oprean, R., Rupérez, F. J., Barbas, C., Boulanger, B., & Hubert, P. (2011). Application of new methodologies based on design of experiments, independent component analysis and design space for robust optimization in liquid chromatography. Analytica Chimica Acta, 691, 33-42. doi:10.1016/j.aca.2011.02.035
Peer Reviewed verified by ORBi

Rozet, E., Lebrun, P., Boulanger, B., Ziemons, E., & Hubert, P. (02 December 2010). Evaluating analytical results reliability using a Bayesian probability criterion [Poster presentation]. Congrès Chimimétrie 2010, Paris, France.

Lebrun, P., Lambert, P., Debrus, B., Hubert, P., Marini Djang'Eing'A, R., Moonen, F., & Boulanger, B. (December 2010). Developing and optimizing analytical chromatographic method in a Quality by Design environment. Bayesian multi-criteria risk-based Design Space to guarantee future quality [Poster presentation]. Chimiométrie 2010, Paris, France.

Lebrun, P., Boulanger, B., & Hubert, P. (04 November 2010). How can QbD be used and implemented to optimize method development and validation? [Paper presentation]. Biological Assay Conference (Informa), London, United Kingdom.

Boulanger, B., Govaerts, B., Le Boulengé, E., Lebrun, P., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2010). Plans expérimentaux. (ULiège - Université de Liège).

Rozet, E., Lebrun, P., Boulanger, B., Ziemons, E., & Hubert, P. (October 2010). Analytical results reliability using a probability criterion: a Bayesian perspective [Poster presentation]. Chemometrics in Analytical Chemistry, Antwerpen, Belgium.

Hubert, P., Ziemons, E., Mantanus, J., Lebrun, P., Boulanger, B., & Rozet, E. (October 2010). RISK MANAGMENT IN THE VALIDATION OF ANALYTICAL METHODS [Paper presentation]. CNFR 2010 Congress, Targu-Mures, Romania.

Lebrun, P., Boulanger, B., & Hubert, P. (28 September 2010). Optimization of ligand-binding assay in a QbD environment. Use of Bayesian non-linear regression to set up probability profile as quality response [Paper presentation]. Non clinical statistics conference, Lyon, France.

Rozet, E., Boulanger, B., Dewe, Ziemons, E., Marini Djang'Eing'A, R., & Hubert, P. (September 2010). Total error as natural decision criteria for analytical methods validation and transfer [Paper presentation]. Drug Analysis 2010, Antwerpen, Belgium.

Debrus, B., Lebrun, P., Boulanger, B., Rozet, E., Caliaro, G., Ceccato, A., & Hubert, P. (September 2010). Implementation of design space concept for the development of robust analytical methods [Poster presentation]. Drug Analysis 2010, Anvers (Antwerp), Belgium.

Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Cao, M., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (September 2010). Application of experimental design and design for the separation of compounds extracted from the leaves of Strychnos Usambarensis [Poster presentation]. Drug analysis 2010, Antwerpen, Belgium.

Lebrun, P., Boulanger, B., Rozet, E., & Hubert, P. (May 2010). Bayesian hierarchical linear regression for the validation of analytical methods [Paper presentation]. PhD days 2010, Gembloux, Belgium.

Lebrun, P., Boulanger, B., & Lambert, P. (May 2010). Use of Bayesian multivariate prediction models to optimize chromatographic methods [Paper presentation]. Bayes 2010, Braine l'Alleud, Belgium.

Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Martine, C., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (26 January 2010). Optimisation de la séparation des alcaloïdes extraits des feuilles de Strychnos usambarensis au moyen du design space [Paper presentation]. Assemblée générale du CIRM et forum des jeunes chercheurs, Liège, Belgium.

Rozet, E., Bouabidi, A., Fillet, M., Ziemons, E., Chapuzet, E., Mertens, B., Klinkenberg, R., Ceccato, A., Talbi, M., Streel, B., Bouklouze, A., Boulanger, B., & Hubert, P. (2010). Critical analysis of several analytical method validation strategies in the framework of the fit for purpose concept. Journal of Chromatography. A, 1217, 3180-3192. doi:10.1016/j.chroma.2009.08.051
Peer Reviewed verified by ORBi

Debrus, B., Lebrun, P., Boulanger, B., Rozet, E., Caliaro, G., Ceccato, A., & Hubert, P. (2010). Development of robust analytical methods using design space methodology [Poster presentation]. Chimiométrie 2010, Paris, France.

Mbinze Kindenge, J., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Lecomte, F., Boulanger, B., & Hubert, P. (December 2009). Développement d’une méthode pour la séparation de 19 antipaludéens par HPLC au moyen de la planification expérimentale et du Design Space [Poster presentation]. 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP'09), Marseille, France.

Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Cao, M., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (December 2009). Application de la planification expérimentale et du design space pour la séparation des composés extraits des feuilles de Strychnos usambarensis [Poster presentation]. 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP'09), Marseille, France.

Boulanger, B., & Lebrun, P. (October 2009). Prediction-based Design Space as a general concept for drug development... and role for statisticians [Paper presentation]. Non-clinical biostatistics conference (NCB09), Boston, United States.

Lebrun, P., & Boulanger, B. (October 2009). Expected Design Space: a Bayesian perspective based on modelling, prediction and multi-criteria decision method [Paper presentation]. Non-clinical biostatistics conference (NCB09), Boston, United States.

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Govaerts, B., Olsen, B. A., Rozet, E., Boulanger, B., & Hubert, P. (30 June 2009). A new statistical method for the automated detection of peaks in UV-DAD chromatograms of a sample mixture. Talanta, 79, 77-85. doi:10.1016/j.talanta.2009.03.009
Peer Reviewed verified by ORBi

Nistor, I., Debrus, B., Lebrun, P., Rozet, E., Ceccato, A., Caliaro, G., Oprean, R., Boulanger, B., & Hubert, P. (27 April 2009). Nouvelle méthodologie pour le développement automatisé de méthodes analytiques en chromatographie liquide pour l'analyse de mélanges de composés inconnus [Paper presentation]. Assemblée générale du CIRM et forum des jeunes chercheurs, Liège, Belgium.

Rozet, E., Fillet, M., Bouabidi, A., Ziemons, E., Talbi, M., Bouklouze, A., Boulanger, B., & Hubert, P. (2009). Critical analysis of several analytical method validation strategies in the framework of the fit for purpose concept [Poster presentation]. HPLC.

Boulanger, B., & Hubert, P. (2009). Short Course on Methof Validation [Paper presentation]. 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques, Dresden, Germany.

Rozet, E., Bouabidi, A., Bouklouze, A., Talbi, M., Boulanger, B., & Hubert, P. (2009). Analysis of several analytical method validation strategies [Poster presentation]. 21st International Symposium on Pharmaceutical and Biomedical Analysis.

Rozet, E., Dewe, W., Boulanger, B., & Hubert, P. (2009). Total Error-Based Criterion for Analytical Method Transfer [Poster presentation]. 21st International Symposium on Pharmaceutical and Biomedical Analysis.

Rozet, E., Boulanger, B., Rudaz, S., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2009). Universal applicability of Total Error for the validation of bioanalytical methods [Paper presentation]. 4èmes JOURNEES INTERNATIONALES de toxicologie, liege, Belgium.

Rozet, E., Boulanger, B., Rudaz, S., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2009). Total Error for the validation of bioanalytical methods [Paper presentation]. TIAFT - The International Association of Forensic Toxicologists.

Rozet, E., Boulanger, B., Rudaz S, Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2009). Total Error for the Valildation of Bioanalytical methods. Annales de Toxicologie Analytique, 21 (S1), 35.
Peer Reviewed verified by ORBi

Rozet, E., Mantanus, J., Ziemons, E., Boulanger, B., Dewe, W., Crommen, J., & Hubert, P. (2009). Practical Implementation of Total Error for the Validation of Chromatographic and Ligand Binding Assays [Paper presentation]. PharmSciFair.

Rozet, E., Rudaz, S., Bouabidi, A., Talbi, M., Bouklouze, A., Boulanger, B., & Hubert, P. (2009). Evaluation of decision methodologies for analytical method validation [Poster presentation]. RDPA - 13th international meeting on recent development in pharmaceutical analysis.

Rozet, E., Boulanger, B., Marini Djang'Eing'A, R., Ziemons, E., Rudaz, S., & Hubert, P. (2009). Validation of bioanalytical methods using total error [Paper presentation]. 21st International Symposium on Pharmaceutical and Biomedical Analysis.

Boulanger, B., Moonen, F., & Hubert, P. (2009). Validation for analytical methods : reducing the risk of decisions. Tutorial 04 [Paper presentation]. 34th international symposium on high performance liquid phase separation and related techniques, Dresden, Germany.

Rozet, E., Dewé, W., Ziemons, E., Bouklouze, A., Boulanger, B., & Hubert, P. (2009). Methodologies for the transfer of analytical methods: A review. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877, 2214-2223. doi:10.1016/j.jchromb.2008.12.049
Peer Reviewed verified by ORBi

Boulanger, B., Rozet, E., Moonen, F., Rudaz, S., & Hubert, P. (2009). A risk-based analysis of the AAPS conference report on quantitative bioanalytical methods validation and implementation. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 (23), 2235-43. doi:10.1016/j.jchromb.2009.06.019
Peer Reviewed verified by ORBi

Lebrun, P., Boulanger, B., Jullion, A., Govaerts, B., Debrus, B., & Hubert, P. (September 2008). Design Space for analytical methods. A Bayesian perspective based on multivariate models and prediction [Paper presentation]. Non-clinical statistics 2008 (NCS2008), Leuven, Belgium.

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Rozet, E., Rupérez, J., Barbas, C., Boulanger, B., & Hubert, P. (July 2008). Chromatographic separation of a pharmaceutical formulation using Design of Experiment and Design Space [Poster presentation]. 11th conference on Chemometrics in Analytical Chemistry (CAC'2008), Montpellier, France.

Lebrun, P., Boulanger, B., Debrus, B., Govaerts, B., & Hubert, P. (June 2008). The Expected Design Space for analytical methods: a new perspective based on modeling and prediction [Paper presentation]. International symposium on biopharmaceutical statistics, Shanghai, China.

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Jupérez, J., Barbas, C., Boulanger, B., & Hubert, P. (June 2008). Usefulness of design space for the optimization of chromatographic separations [Paper presentation]. 19th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2008), Gdansk, Poland.

Lebrun, P., Debrus, B., Boulanger, B., Govaerts, B., & Hubert, P. (May 2008). Use of Independent Component Analysis and clustering methods to find and identify relevant components in a matrix of UV-spectral data.

Eppe, G., Van Cleuvenbergen, R., Smastuen Haug, L., Boulanger, B., Becher, G., & De Pauw, E. (March 2008). Empirical Relationship between Precision and Ultra-Trace Concentrations of Pcdd/Fs and Dioxin-Like Pcbs in Biological Matrices. Chemosphere, 71 (2), 379-87. doi:10.1016/j.chemosphere.2007.08.046
Peer Reviewed verified by ORBi

Lebrun, P., Govaerts, B., Debrus, B., Ceccato, A., Caliaro, G., Hubert, P., & Boulanger, B. (2008). Development of a new predictive modelling technique to find with confidence equivalence zone and design space of chromatographic analytical methods. Chemometrics and Intelligent Laboratory Systems, 91, 4-16. doi:10.1016/j.chemolab.2007.05.010
Peer Reviewed verified by ORBi

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Laurentie, M., Mercier, N., Muzard, G., Valat, L., & Rozet, E. (2008). Harmonization of strategies for the validation of quantitative analytical procedures: a SFSTP proposal part IV. Examples of application. Journal of Pharmaceutical and Biomedical Analysis, 48 (3), 760-71. doi:10.1016/j.jpba.2008.07.018
Peer Reviewed verified by ORBi

Rozet, E., Dewé, W., Morello, R., Chiap, P., Lecomte, F., Ziemons, E., Boos, K. S., Boulanger, B., Crommen, J., & Hubert, P. (2008). Risk-Based Approach for the Transfer of Quantitative Methods: Bioanalytical Applications. Journal of Chromatography. A, 1189, 32-41. doi:10.1016/j.chroma.2007.11.029
Peer Reviewed verified by ORBi

Rozet, E., Dewe, W., Boulanger, B., Ziemons, E., Hubert, C., Moonen, F., & Hubert, P. (2008). Simultaneous improvement of the predictive character of the validation data and estimation of measurement uncertainty [Paper presentation]. Agrostat, Louvain-la-Neuve, Belgium.

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivet, C., Valat, L., & Rozet, E. (21 September 2007). Harmonization of strategies for the validation of quantitative analytical procedures - A SFSTP proposal - Part II. Journal of Pharmaceutical and Biomedical Analysis, 45 (1), 70-81. doi:10.1016/j.jpba.2007.06.013
Peer Reviewed verified by ORBi

Rozet, E., Hubert, C., Ceccato, A., Dewé, W., Ziemons, E., Moonen, F., Michail, K., Wintersteiger, R., Streel, B., Boulanger, B., & Hubert, P. (27 July 2007). Using tolerance intervals in pre-study validation of analytical methods to predict in-study results - The fit-for-future-purpose concept. Journal of Chromatography. A, 1158 (1-2), 126-137. doi:10.1016/j.chroma.2007.03.102
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Servais, A.-C., Rozet, E., Chiap, P., Boulanger, B., Rudaz, S., Crommen, J., Hubert, P., & Fillet, M. (June 2007). Enantiomeric purity testing of S-timolol by non-aqueous CE using heptakis(2,3-di-O-methyl-6-O-Sulfo)-β-cyclodextrin as chiral additive – Validation using the accuracy profile strategy and estimation of uncertainty [Poster presentation]. 31st International Symposium on HPLC and Related techniques, Gand, Belgium.

Lebrun, P., Debrus, B., Boulanger, B., Caliaro, G., Ceccato, A., & Hubert, P. (June 2007). Numerical separation in HPLC-UV-DAD with Independent Component Analysis (ICA) using high order statistics for the automated identification of peaks [Poster presentation]. HPLC 2007, Gent, Belgium.

Rozet, E., Wascotte, V., Lecouturier, N., Préat, V., Dewé, W., Boulanger, B., & Hubert, P. (May 2007). Improvement of the decision efficiency of the accuracy profile by means of a desirability function for analytical methods validation - Application to a diacetyl-monoxime colorimetric assay used for the determination of urea in transdermal iontophoretic extracts. Analytica Chimica Acta, 591 (2), 239-247. doi:10.1016/j.aca.2007.04.002
Peer Reviewed verified by ORBi

Debrus, B., Lebrun, P., Boulanger, B., Dewé, W., Ceccato, A., & Hubert, P. (20 March 2007). Séparation numérique et quantification automatique de pics en CLHP-UV grâce à l’utilisation de l’analyse en composantes indépendantes (ICA) [Paper presentation]. SEP 2007, Grenoble, France.

Debrus, B., Lebrun, P., Boulanger, B., Dewé, W., Ceccato, A., & Hubert, P. (20 March 2007). Evaluation d'une nouvelle méthode pour le développement entièrement automatisé de méthodes analytiques en chromatographie liquide [Poster presentation]. SEP 2007, Grenoble, France.

Hubert, C., Rozet, E., Ceccato, A., Dewé, W., Ziemons, E., Moonen, F., Michail, K., Wintersteiger, R., Streel, B., Boulanger, B., & Hubert, P. (March 2007). Validation versus routine : Evaluation de l'aspect prédictif de l'intervalle de tolérance [Poster presentation]. 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages, Grenoble, France.

Dewé, W., Govaerts, B., Boulanger, B., Rozet, E., Chiap, P., & Hubert, P. (15 February 2007). Using total error as decision criterion in analytical method transfer. Chemometrics and Intelligent Laboratory Systems, 85 (2), 262-268. doi:10.1016/j.chemolab.2006.07.003
Peer Reviewed verified by ORBi

Boulanger, B., Dewé, W., Moonen, F., & Hubert, P. (2007). Prediction-based decision for validation of (bio)analytical methods using tolerance intervals and accuracy profiles.

Marini Djang'Eing'A, R., Rozet, E., Vanderheyden, Y., Ziemons, E., Boulanger, B., Bouklouze, A., Servais, A.-C., Fillet, M., Crommen, J., & Hubert, P. (2007). Robustness testing of a chiral NACE method for R-timolol determination in S-timolol maleate and uncertainty assessment from quantitative data. Journal of Pharmaceutical and Biomedical Analysis, 44 (3), 640-51. doi:10.1016/j.jpba.2006.08.018
Peer Reviewed verified by ORBi

Rozet, E., Dewe, W., Boulanger, B., & Hubert, P. (2007). Total Error-Based Criterion for Analytical Method Transfer Experiments [Paper presentation]. AMSTAT Joint Statistical Meeting.

Rozet, E., Dewe, W., Boulanger, B., Ziemons, E., Marini Djang'Eing'A, R., Moonen, F., & Hubert, P. (2007). LA PREDICTION DES RISQUES ASSOCIES AUX DONNEES DU CYCLE DE VIE DES METHODES DE DOSAGE [Paper presentation]. VI Colloquium Chemometricum Mediterraneum.

Rozet, E., Dewe, W., Morello, R., Chiap, P., Ziemons, E., Boos, K. S., Boulanger, B., & Hubert, P. (2007). GESTION DU RISQUE LORS DU TRANSFERT DE METHODES ANALYTIQUES – CAS D’UNE METHODE BIOANALYTIQUE [Paper presentation]. SEP07.

Hubert, P., Nguyen-Huu, J. J., Boulanger, B., Chapuzet, E., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Laurentie, M., Mercier, N., Muzard, G., Valat, L., & Rozet, E. (2007). Harmonization of strategies for the validation of quantitative analytical procedures - A SFSTP proposal - Part III. Journal of Pharmaceutical and Biomedical Analysis, 45 (1), 82-96. doi:10.1016/j.jpba.2007.06.032
Peer Reviewed verified by ORBi

Boulanger, B., & Hubert, P. (2007). Short Course on Method validation [Paper presentation]. 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques, Gand, Belgium.

Rozet, E., Dewe, W., Boulanger, B., Ziemons, E., Hubert, C., Marini Djang'Eing'A, R., Moonen, F., & Hubert, P. (2007). PREDICTION OF THE RISKS LINKED TO THE DATA GENERATED DURING THE LIFE CYCLE OF QUANTITATIVE ANALYTICAL METHODS [Paper presentation]. 13eme Forum des Sciences Pharmaceutiques, Spa, Belgium.

Boulanger, B., Dewé, W., Hubert, P., & Moonen, F. (2007). Statistical considerations for the validation of an ELISA assay as biomarker [Paper presentation]. Bioassays in clinical development, Londres, United Kingdom.

Rozet, E., Dewe, W., Govaerts, B., Boulanger, B., Moonen, F., Crommen, J., & Hubert, P. (2007). PAT COMPLIENT APPROACHES TO ASSESS THE ACCEPTABILITY OF ANALYTICAL METHOD TRANSFER: HOW TO LIMIT THE RISK TO OBTAIN OOS RESULTS? [Poster presentation]. RDPA - 12th international meeting on Recent Development in Pharmaceutical Analysis.

Oprean, R., Rozet, E., Dewé, W., Boulanger, B., & Hubert, P. (2007). Guide for validation of analytical procedures. Cluj-Napoca, Romania: Medicala Universitara “Iuliu Hatieganu”.

Boulanger, B., Dewé, W., Moonen, F., & Hubert, P. (2007). Prediction-based decision for validation of (bio)analytical methods using tolerance intervals and accuracy profiles [Paper presentation]. Joint Statistical Meeting, Salt Lake City, United States.

Rozet, E., Dewe, W., Govaerts, B., Boulanger, B., Ceccato, A., Chiap, P., Crommen, J., & Hubert, P. (2007). Evaluation of Analytical Method Transfer on a Risk Based Methodology using Total Error [Paper presentation]. HPLC.

Rozet, E., Ceccato, A., Hubert, C., Ziemons, E., Oprean, R., Rudaz, S., Boulanger, B., & Hubert, P. (2007). Analysis of recent pharmaceutical regulatory documents on analytical method validation. Journal of Chromatography. A, 1158 (1-2), 111-25. doi:10.1016/j.chroma.2007.03.111
Peer Reviewed verified by ORBi

Lebrun, P., Boulanger, B., Hubert, P., Debrus, B., & Govaerts, B. (December 2006). Statistical Models and Multi-Criteria Optimization Techniques in Chromatography [Paper presentation]. Chimiométrie 2006, Paris, France.

Boulanger, B., Dewé, W., Ceccato, A., Debrus, B., Lebrun, P., & Hubert, P. (December 2006). Utilisation de l’Analyse en Composantes Indépendantes (ICA) pour la séparation numérique des pics et la quantification automatique en CLHP-UV [Paper presentation]. Chimiométrie 2006, Paris, France.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Rudaz, S., Rozet, E., Crommen, J., & Hubert, P. (November 2006). Comparaison de trois approches pour l'estimation de l'incertitude [Paper presentation]. 3ème journée internationale de toxicologie hospitalière, Liège, Belgium.

Hubert, P., Rozet, E., Crommen, J., Dewé, W., & Boulanger, B. (28 September 2006). développement récent dans le domaine de la validation des méthodes analytiques [Paper presentation]. 13e Congrès National de Pharmacie, Cluj-Napoca, Romania.

Rozet, E., Mertens, B., Dewé, W., Ceccato, A., Govaerts, B., Boulanger, B., Chiap, P., Streel, B., Crommen, J., & Hubert, P. (11 September 2006). The transfer of a LC-UV method for the determination of fenofibrate and fenofibric acid in Lidoses: Use of total error as decision criterion. Journal of Pharmaceutical and Biomedical Analysis, 42 (1), 64-70. doi:10.1016/j.jpba.2005.12.037
Peer Reviewed verified by ORBi

Lecomte, F., Aerts, J., Plenevaux, A., Lignon, S., Haber, G., Boulanger, B., Chiap, P., Luxen, A., & Hubert, P. (September 2006). EVALUATION OF MOLECULARLY IMPRINTED POLYMERS BY MEANS OF EXPERIMENTAL DESIGN PRIOR TO THE DETERMINATION OF p-[18F]MPPF IN PLASMA [Poster presentation]. MIP2006 - Fourth International Workshop on Molecularly Imprinted Polymers, Cardiff, United Kingdom.

Rozet, E., Dewe, W., Boulanger, B., & Hubert, P. (11 May 2006). Comparaison de différentes approches pour accepter un transfert de méthodes analytiques [Paper presentation]. Club Lyonnais de Chromatographie, Lyon, France.

Marini Djang'Eing'A, R., Rozet, E., Ziemons, E., Chiap, P., Boulanger, B., Rudaz, S., Servais, A.-C., Fillet, M., Crommen, J., & Hubert, P. (May 2006). COMPARISON OF THREE DIFFERENT APPROACHES FOR UNCERTAINTY ESTIMATION CONSIDERING LC AND CE METHODS [Paper presentation]. A joint meeting of two distinguished series: the 8th International Symposium on Drug Analysis and the 17th International Symposium on Pharmaceutical and Biomedical Analysis, Namur, Belgium.

Hubert, C., Rozet, E., Boulanger, B., Dewé, W., Breuer, A., Collard, L., Evrard, B., & Hubert, P. (May 2006). Validation of a LC method for the determination of levonorgestrel released from a polymeric matrix. A two days protocol [Poster presentation]. Drug Analysis 2006, Namur, Belgium.

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Laurentie, M., Mercier, N., Muzard, G., & Valat, L. (April 2006). Validation des procédures analytiques quantitatives :harmonisation des démarches - Partie III. Exemples d’application. STP Pharma Pratiques, 16 (2), 87-121.
Peer reviewed

Lecomte, F., Boulanger, B., Hall, A. J., Sellergren, B., Crommen, J., Chiap, P., & Hubert, P. (March 2006). Développement d’une méthode de dosage automatisé du méthotrexate dans le plasma humain par couplage direct à la chromatographie liquide de l’extraction sur phase solide à empreintes moléculaires [Poster presentation]. Forum LABO & Forum BIOTECH 2006, Paris, France.

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Cohen, N., compagnon, P.-A., Dewé, W., Feinberg, M., Laurentie, M., Mercier, N., & Muzard, G. (January 2006). Validation des procédures analytiques quantitatives :Partie II - Statistiques. STP Pharma Pratiques, 16 (1), 28-58.
Peer reviewed

Feinberg, M., Laurentie, M., Hubert, P., Boulanger, B., & Dewé, W. (2006). Les laboratoires accrédités saisis par l'incertitude [Paper presentation]. Forum Labo, Paris, France.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Rudaz, S., Rozet, E., Crommen, J., & Hubert, P. (2006). Comparaison de trois approches pour l'estimation de l'incertitude. Acta Clinica Belgica. Supplementum, (1), 60-2.
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Groom, C., Doucet, F. R., Hawari, J., Bitar, Y., Holzgrabe, U., Gotti, R., Schappler, J., Rudaz, S., Veuthey, J.-L., Mol, R., Somsen, G. W., de Jong, G. J., Ha, P. T. T., Zhang, J., Van Schepdael, A., Hoogmartens, J., Brione, W., Ceccato, A., ... Hubert, P. (2006). Interlaboratory study of a NACE method for the determination of R-timolol content in S-timolol maleate: assessment of uncertainty. Electrophoresis, 27 (12), 2386-99. doi:10.1002/elps.200500832
Peer Reviewed verified by ORBi

Rozet, E., Boulanger, B., Dewe, W., Hubert, P., & Moonen, F. (2006). Applying statistics recomended by regulatory documents [Paper presentation]. Method Validation.

Rozet, E., Boulanger, B., Dewe, W., Chiap, P., Moonen, F., Govaerts, B., Crommen, J., & Hubert, P. (2006). GERER LE RISQUE LORS DE LA VALIDATION DES METHODES ANALYTIQUES : APPLICATION A LA DETERMINATION D’IMPURETES [Paper presentation]. Congrès des Sciences Analytiques, Marrakech, Morocco.

Hubert, P., Rozet, E., Boulanger, B., Dewé, W., Laurentie, M., Dubois, N., Charlier, C., & Feinberg, M. (2006). Synchronization of validation and estimation strategies of doubt associated as part of the accreditation in trial laboratories. Acta Clinica Belgica, 61 (Suppl. 1), 54-56.
Peer Reviewed verified by ORBi

Boulanger, B., Dewé, W., Hubert, P., & Govaerts, B. (2006). Conciliating objectives of analytical methods and objectives of validation : a statistical perspective [Paper presentation]. I.V.T, Amsterdam, Netherlands.

Rozet, E., Ziemons, E., Eppe, G., Dewe, W., Boulanger, B., & Hubert, P. (2006). SIMULTANEOUS ESTIMATION OF MEASUREMENT UNCERTAINTY AND IMPLEMENTATION OF CONTROL CHART USING QUALITY CONTROL STANDARDS [Poster presentation]. Drug Analysis.

Marini Djang'Eing'A, R.* , Servais, A.-C.* , Rozet, E., Chiap, P., Boulanger, B., Rudaz, S., Crommen, J., Hubert, P., & Fillet, M. (2006). Nonaqueous capillary electrophoresis method for the enantiomeric purity determination of S-timolol using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin: validation using the accuracy profile strategy and estimation of uncertainty. Journal of Chromatography. A, 1120 (1-2), 102-11. doi:10.1016/j.chroma.2006.03.104
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Rozet, E., Morello, R., Dewe, W., Chiap, P., Boulanger, B., Boos, K. S., Crommen, J., & Hubert, P. (2006). TRANSFER OF A MULTIDIMENSIONAL ON-LINE SPE-LC-ECD METHOD FOR THE DETERMINATION OF THREE MAJOR CATECHOLAMINES IN NATIVE HUMAN URINE [Poster presentation]. HPLC.

Hubert, P., Rozet, E., Boulanger, B., Dewé, W., Laurentie, M., Dubois, N., Charlier, C., & Feinberg, M. (2006). Harmonisation des strategies de validation et estimation de l'incertitude associee dans le cadre de l'accreditation des laboratoires d'essais. Acta Clinica Belgica. Supplementum, S1 (1), 53-55.
Peer Reviewed verified by ORBi

Boulanger, B., Dewé, W., Hubert, P., Govaerts, B., & Hammer, C. (2006). Accuracy and precision : total error vs 4-6-30 [Paper presentation]. 3rd bioanalytical workshop on quantitative methods validation and implementation, Crystal City, United States.

Dewé, W., Boulanger, B., Govaerts, B., Rozet, E., & Hubert, P. (2006). Approches par l'erreur totale en transfert analytique [Paper presentation]. Forum Labo, Paris, France.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Rudaz, S., Rozet, E., Crommen, J., & Hubert, P. (2006). LC method for the determination of R-timolol in S-timolol maleate: Validation of its ability to quantify and uncertainty assessment. Talanta, 68 (4), 1166-1175. doi:10.1016/j.talanta.2005.07.026
Peer Reviewed verified by ORBi

Lecomte, F., Boulanger, B., Hall, A. J., Sellergren, B., Rozet, E., Crommen, J., Chiap, P., & Hubert, P. (September 2005). OPTIMIZATION OF MOLECULARLY IMPRINTED SOLID-PHASE EXTRACTION BY MEANS OF EXPERIMENTAL DESIGN PRIOR TO THE DETERMINATION OF METHOTREXATE IN HUMAN PLASMA [Poster presentation]. RDPA 2005 - 11th International Meeting on Recent Developments in Pharmaceutical Analysis, Rimini, Italy.

Marini Djang'Eing'A, R., Boulanger, B., Vanderheyden, Y., Chiap, P., Crommen, J., & Hubert, P. (21 February 2005). Uncertainty assessment from robustness testing applied on an LC assay for R-timolol and other related substances in S-timolol maleate. Analytica Chimica Acta, 531 (1), 131-140. doi:10.1016/j.aca.2004.10.004
Peer Reviewed verified by ORBi

Rozet, E., Mertens, B., Dewe, W., Govaerts, B., Boulanger, B., Chiap, P., Streel, B., Crommen, J., & Hubert, P. (2005). USING TOTAL ERROR AS DECISION CRITERION IN METHOD TRANSFER [Poster presentation]. RDPA-Recent Development on Pharmaceutical Analysis.

Chiap, P., Boulanger, B., Dewé, W., Crommen, J., & Hubert, P. (2005). Recent trends in the validation of bioanalytical methods [Paper presentation]. PharmSciFair, Nice, France.

Marini Djang'Eing'A, R., Matthijs, N., Vanderheyden, Y., Smeyers-Verbeke, J., Dehouck, P., Hoogmartens, J., Silvestre, P., Ceccato, A., Goedert, P., Saevels, J., Herbots, C., Caliaro, G., Herraez-Hernandez, R., Verdu-Andres, J., Campins-falco, P., de Wauw, W. V., De Beer, J., Boulanger, B., Chiap, P., ... Hubert, P. (2005). Collaborative study of an liquid chromatographic method for the determination of R-timolol and other related substances in S-timolol maleate. Analytica Chimica Acta, 546 (2), 182-192. doi:10.1016/j.aca.2005.05.026
Peer Reviewed verified by ORBi

Rozet, E., Wascotte, V., Lecouturier, N., Preat, V., Dewe, W., Boulanger, B., & Hubert, P. (2005). USE OF THE ACCURACY PROFILE FOR THE VALIDATION OF A DIACETYL-MONOXIME COLORIMETRIC METHOD FOR THE DETERMINATION OF UREA IN TRANSDERMAL IONTOPHORETIC EXTRACTS [Poster presentation]. RDPA - Recent Development in Pharmaceutical Analysis.

Eppe, G., Boulanger, B., Hubert, P., Scippo, M.-L., Maghuin-Rogister, G., & De Pauw, E. (2005). Evaluating measurement uncertainty for dioxins in routine analysis by the accuracy profile approach [Poster presentation]. 2nd symposium on recent advances in food analysis, Prague, Czechia.

Rozet, E., Chiap, P., Dewe, W., Boulanger, B., Crommen, J., & Hubert, P. (2005). The Usefulness of Accuracy Profile to Validate Analytical Methods [Paper presentation]. RDPA - Recent Developement in Pharmaceutical Analysis.

Dewé, W., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., & Boulanger, B. (28 December 2004). Development of response models for optimising HPLC methods. Chemometrics and Intelligent Laboratory Systems, 74 (2), 263-268. doi:10.1016/j.chemolab.2004.04.016
Peer Reviewed verified by ORBi

Hubert, P., Nguyen-Huu, J.-J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P.-A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivet, C., & Valat, L. (15 November 2004). Harmonization of strategies for the validation of quantitative analytical procedures - A SFSTP proposal - part I. Journal of Pharmaceutical and Biomedical Analysis, 36 (3), 579-586. doi:10.1016/j.jpba.2004.07.027
Peer Reviewed verified by ORBi

Feinberg, M., Boulanger, B., Dewé, W., & Hubert, P. (October 2004). New advances in method validation and measurement uncertainty aimed at improving the quality of chemical data. Analytical and Bioanalytical Chemistry, 380 (3), 502-514. doi:10.1007/s00216-004-2791-y
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Boulanger, B., Abushoffa, A., Fillet, M., Chiap, P., Hubert, P., & Crommen, J. (February 2004). ENANTIOMERIC PURITY TESTING OF S-KETOPROFEN IN PHARMACEUTICAL FORMULATIONS BY CE USING A DUAL CYCLODEXTRIN SYSTEM [Poster presentation]. 17th International Symposium on Microscale Separations and Capillary Electrophoresis, Salzburg, Austria.

Boulanger, B., Dewé, W., & Hubert, P. (2004). Setting acceptance criteria and total error criteria [Paper presentation]. Bioval 2004, London, United Kingdom.

Rudaz, S., Rollason, V., Desmeules, J., Dayer, P., Veuthey, J. L., Boulanger, B., & Hubert, P. (2004). Impact of calibration models for the validation of a liquid chromatography method for paracetamol, tramadol and its main o-desmethylated metabolite in serum samples [Paper presentation]. 15th international symposium on pharmaceutical and biomedical analysis, Florence, Italy.

Chiap, P., Dewé, W., Boulanger, B., Crommen, J., & Hubert, P. (2004). Use of accuracy profiles as efficient decision tool for the validation of quantitative analytical methods [Poster presentation]. 15th international symposium on pharmaceutical and biomedical analysis, Florence, Italy.

Boulanger, B., Dewé, W., & Hubert, P. (2004). Objectives of analytical methods and objectives of validation. How to reconcile them ? [Paper presentation]. 4th international workshop on statistical methods in non-clinical R et D, Dublin, Ireland.

Hubert, P., Chiap, P., Dormal, C., Crommen, J., Dewé, W., & Boulanger, B. (2004). Intérêt du profil d'exactitude dans le cadre de la validation des méthodes analytiques [Poster presentation]. Forum labo et Forum biotech, Paris, France.

Dewé, W., Boulanger, B., & Hubert, P. (2004). Towards a better use of statistics in method validation [Paper presentation]. Applied statistics workshop, Bruxelles, Belgium.

Hubert, P., Boulanger, B., Dewé, W., Chiap, P., & Crommen, J. (2004). Harmonisation des stratégies de validation, utopie ou réalité ? [Paper presentation]. Forum labo et forum biotech, Paris, France.

Boulanger, B., Dewé, W., & Hubert, P. (2004). Validation of quantitation methods [Paper presentation]. Bioforum, Liège, Belgium.

Laurentie, M., Manceau, J., Dewé, W., Boulanger, B., & Hubert, P. (2004). The use of total error to validate analytical method : examples of applications [Paper presentation]. Second international conference on antimicrobial agents in veterinary medicine, Ottawa, Canada.

Boulanger, B., Chiap, P., Dewé, W., Crommen, J., & Hubert, P. (08 August 2003). An analysis of the SFSTP guide on validation of chromatographic bioanalytical methods: progresses and limitations. Journal of Pharmaceutical and Biomedical Analysis, 32 (4-5), 753-765. doi:10.1016/S0731-7085(03)00182-1
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Dewé, W., Hubert, P., & Crommen, J. (July 2003). LC method for the simultaneous determination of R-timolol and other closely related impurities in S-timolol maleate: Optimization by use of an experimental design. Journal of Separation Science, 26 (9-10), 809-817. doi:10.1002/jssc.200301367
Peer Reviewed verified by ORBi

Hubert, P., Nguyen-Huu, J. J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P. A., Dewé, W., Feinberg, M., Lallier, M., Laurentie, M., Mercier, N., Muzard, G., Nivert, C., & Valat, L. (May 2003). Validation des procédures analytiques quantitatives, Harmonisation des démarches. STP Pharma Pratiques, 13 (3), 101-138.
Peer reviewed

Hubert, P., Chiap, P., Laurentie, M., Dewé, W., Boulanger, B., & Crommen, J. (2003). Harmonisation des démarches de validation, est-elle possible ? [Paper presentation]. 5E Congrès francophone sur les techniques séparatives et les couplages (SEP 2003), Lyon, France.

Boulanger, B., Marini Djang'Eing'A, R., Chiap, P., Dewé, W., Crommen, J., & Hubert, P. (2003). Objectives of analytical methods and objectives of validation : how to reconciliate them ? [Paper presentation]. HPLC 2003, 27th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Nice, France.

Dewé, W., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., & Boulanger, B. (2003). Development of response models for optimising HPLC methods [Poster presentation]. HPLC ‘03, 27th International Symposium on High Performance Liquid Phase Separations an Related Techniques, Nice, France.

Laurentie, M., Boulanger, B., Dewé, W., & Hubert, P. (2003). Statistical analysis of validation method revisited : the need to use the total error [Paper presentation]. 9th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Lisboa, Portugal.

Chiap, P., Crommen, J., Dormal, C., Dewé, W., Boulanger, B., & Hubert, P. (2003). Intérêt du profil d’exactitude dans le cadre de la validation d’une méthode de dosage par chromatographie liquide du miconazole, de l’éconazole et du sor-bate dans les préparations à usage dermatologie [Poster presentation]. 5E Congrès francophone sur les techniques séparatives et les couplages (SEP 2003), Lyon, France.

Laurentie, M., Boulanger, B., Dewé, W., & Hubert, P. (2003). Statistical analysis of validation method revisited : the need to use the total error. Proceeding 9th international congress of the european association for Veterinary Pharmacology and Toxicology. Journal of Veterinary Pharmacology and Therapeutics, 26, 302-303.
Peer Reviewed verified by ORBi

Hubert, P., Chiap, P., Dewé, W., Boulanger, B., & Crommen, J. (2003). Harmonization of validation strategies for analytical methods [Paper presentation]. 4th international symposium on pharmaceutical chemistry, Istanbul, Turkey.

Boulanger, B., Dewé, W., Chiap, P., Crommen, J., & Hubert, P. (2003). Objectives of analytical methods and objectives of validation [Paper presentation]. Landolake conference, Wisconsin, United States.

Dewé, W., Marini Djang'Eing'A, R., Chiap, P., Hubert, P., Crommen, J., & Boulanger, B. (December 2002). Développement de modèles de réponse pour l’optimisation de méthodes HPLC [Paper presentation]. Chimiométrie 2002, Paris, France.

Marini Djang'Eing'A, R., Chiap, P., Boulanger, B., Dewé, W., Hubert, P., & Crommen, J. (April 2002). DEVELOPMENT AND VALIDATION OF A SIMULTANEOUS LC METHOD FOR THE DETERMINATION OF S-TIMOLOL MALEATE, ITS ANTIPODE AND RELATED SUBSTANCES USING A CELLULOSE BASED CHIRAL STATIONARY PHASE [Poster presentation]. Drug Analysis 2002 Symposium, Bruges, Belgium.

Boulanger, B., Dewé, W., Chiap, P., Crommen, J., & Hubert, P. (2002). Objectifs des méthodes analytiques et objectifs de la validation. Comment les réconcilier pour garantir la qualité des résultats ? [Paper presentation]. Chimiométrie, Paris, France.

Boulanger, B., Dewé, W., Chiap, P., & Hubert, P. (2002). Objectives of validation : the statistical rationale of the SFSTP [Paper presentation]. Bioval 2002, London, United Kingdom.

Chiap, P., Lambert, E., Dormal, C., Hubert, P., Dewé, W., & Boulanger, B. (2002). Use of the accuracy profile for the validation of a generic LC method for the determination of miconazole, econazole and sorbate in dermatological forms [Poster presentation]. 7th International Symposium on Drug Analysis, Bruges, Belgium.

Hubert, P., Chiap, P., Dormal, C., Crommen, J., Dewé, W., & Boulanger, B. (2002). Intérêt du profil d’exactitude dans le cadre de la validation des méthodes ana-lytiques [Paper presentation]. Club chimiométrie et assurance qualité, INRA, Paris, France.

Hubert, P., Chiap, P., Dormal, C., Dewé, W., Boulanger, B., & Crommen, J. (2002). Statistical analysis of the validation results: diagnostic or decision tools [Paper presentation]. 7th International Symposium on Drug Analysis, Bruges, Belgium.

Boulanger, B., Dewé, W., Chiap, P., Crommen, J., & Hubert, P. (2002). Objectives and analytical methods and objectives of validation [Paper presentation]. Barnett Conference, Philadelphie, United States.

Hubert, P., Chiap, P., Dormal, C., Boulanger, B., Dewé, W., & Crommen, J. (2002). Intérêt du profil d'exactitude dans le cadre de la validation des méthodes analytiques [Paper presentation]. Forum Labo, Paris, France.

Chiap, P., Ceccato, A., Miralles Buraglia, B., Boulanger, B., Hubert, P., & Crommen, J. (March 2001). Development and Validation of an Automated Method for the Liquid Chromatographic Determination of Sotalol in Plasma Using Dialysis and Trace Enrichment on a Cation-Exchange Pre-Column as on-Line Sample Preparation. Journal of Pharmaceutical and Biomedical Analysis, 24 (5-6), 801-14. doi:10.1016/S0731-7085(00)00547-1
Peer Reviewed verified by ORBi

Hubert, P., Chiap, P., Dewé, W., Boulanger, B., & Crommen, J. (2001). The usefulness of accuracy profiles in LC method validation [Paper presentation]. HPLC 2001, Maastricht, Netherlands.

Chiap, P., Boulanger, B., Fotsing, L., Hubert, P., & Crommen, J. (2001). Liquid chromatographic analysis of local anesthetics in human plasma after sample preparation by on-line dialysis. Optimization by use of experimental design. Chromatographia, 53 (11-12), 678-686. doi:10.1007/BF02493020
Peer Reviewed verified by ORBi

Hubert, P., Boulanger, B., Chiap, P., Dewé, W., & Crommen, J. (2001). Développements récents dans le domaine de la validation de méthodes en analyse pharmaceutique et biomédicale [Paper presentation]. SEP 2001, Paris, France.

Boulanger, B., Dewé, W., Chiap, P., & Hubert, P. (2001). Objectives of validation : the statistical rationale of the SFSTP [Paper presentation]. ISPC, Istanbul, Turkey.

Fotsing, L., Boulanger, B., Chiap, P., Fillet, M., Hubert, P., & Crommen, J. (2000). Multivariate optimization approach for the separation of water-soluble vitamins and related compounds by capillary electrophoresis. Biomedical Chromatography: BMC, 14 (1), 10-1. doi:10.1002/(SICI)1099-0801(200002)14:1<10::AID-BMC947>3.0.CO;2-8
Peer Reviewed verified by ORBi

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (2000). Example of application of the new strategy proposed for the validation of chromatographic bioanalytical methods. STP Pharma Pratiques, 10 (2), 79-101.
Peer reviewed

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (2000). New strategy for the validation of chromatographic bioanalytical methods. STP Pharma Pratiques, 10 (1), 21-38.
Peer reviewed

Boulanger, B., Dewé, W., Chiap, P., & Hubert, P. (2000). Objectives of pre-study validation and decision rules [Paper presentation]. AAPS Workshop on bioanalytical methods validation – A revisit with a decade of progress, Arlington, United States.

Fotsing, L., Fillet, M., Boulanger, B., Chiap, P., Hubert, P., & Crommen, J. (2000). Determination of water-soluble vitamins and related compounds by capillary electrophoresis using a multivariate approach for method development [Poster presentation]. XIIIth International Symposium on High Performance Capillary Electrophoresis, Saarbrucken, Germany.

Hubert, P., Boulanger, B., Chiap, P., Dewé, W., & Crommen, J. (2000). Analyse statistique des résultats de validation de méthodes d’analyse chromatographiques [Paper presentation]. Les Journées du GMP, Bordeaux, France.

Chiap, P., Hubert, P., Boulanger, B., & Crommen, J. (2000). Plans d’expérience en biolanalyse : optimisation d’une méthode de dialyse pour le traitement d’échantillons plasmatiques préalable à leur analyse chromatographique [Paper presentation]. Journées du GMP, Bordeaux, France.

Hubert, P., Chiap, P., Crommen, J., Boulanger, B., Chapuzet, E., Mercier, N., Bervoas-Martin, S., Chevalier, P., Grandjean, D., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (1999). The SFSTP guide on the validation of chromatographic methods for drug bioanalysis: from the Washington Conference to the laboratory. Analytica Chimica Acta, 391 (2), 135-148. doi:10.1016/S0003-2670(99)00106-3
Peer Reviewed verified by ORBi

Chiap, P., Hubert, P., Boulanger, B., & Crommen, J. (1999). Validation of an automated method for the liquid chromatographic determination of atenolol in plasma: application of a new validation protocol. Analytica Chimica Acta, 391 (2), 227-238. doi:10.1016/S0003-2670(99)00117-8
Peer Reviewed verified by ORBi

Fotsing, L., Boulanger, B., Chiap, P., Fillet, M., Hubert, P., & Crommen, J. (1999). Determination of copper, iron and zinc in pharmaceutical formulations by capillary electrophoresis [Poster presentation]. 23rd International Symposium on high performance liquid phase separations and related techniques, Grenade, Spain.

Fotsing, L., Boulanger, B., Chiap, P., Fillet, M., Hubert, P., & Crommen, J. (1999). Multivariate optimisation approach for the separation of water-soluble vitamins and related compounds by capillary electrophoresis [Poster presentation]. IIIrd Miniaturisation in Liquid Chromatography versus Capillary Electrophoresis Conference, Gand, Belgium.

Ceccato, A., Boulanger, B., Chiap, P., Hubert, P., & Crommen, J. (11 September 1998). Simultaneous Determination of Methylphenobarbital Enantiomers and Phenobarbital in Human Plasma by on-Line Coupling of an Achiral Precolumn to a Chiral Liquid Chromatographic Column. Journal of Chromatography. A, 819 (1-2), 143-53. doi:10.1016/S0021-9673(98)00547-0
Peer Reviewed verified by ORBi

Boulanger, B., Caliaro, G., Dewé, W., Engel, M., Vandenhende, M., & Hubert, P. (1998). Finding rugged pareto optimal solutions in HPLC by means of models : simple is efficient. Journal de Pharmacie de Belgique, 53, 162.
Peer Reviewed verified by ORBi

Hubert, P., Boulanger, B., & Veuthey, J. L. (1998). validation de méthodes analytiques [Paper presentation]. Professional training in analytical chemistry, Eurocours Leonardo Da Vinci, Genève, Switzerland.

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorge, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (1998). Méthodes chromatographiques de dosage dans les milieux biologiques : exemple d'application de la stratégie de validation - Rapport d'une commission SFSTP. STP Pharma Pratiques, 8 (2), 81-107.
Peer reviewed

Hubert, P., & Boulanger, B. (1998). Validation des méthodes d’analyse des médicaments dans les milieux biologiques.

Chiap, P., Boulanger, B., Ceccato, A., Hubert, P., & Crommen, J. (1998). On-line coupling of dialysis to liquid chromatography for the automated determination of some local anaesthetics in human plasma. Journal de Pharmacie de Belgique, 53, 172.
Peer Reviewed verified by ORBi

Chiap, P., Boulanger, B., Bimazubute, M., Hubert, P., & Crommen, J. (1998). Validation of an automated method for the LC determination of atenolol in plasma : application of a new validation strategy. Journal de Pharmacie de Belgique, 53, 171.
Peer Reviewed verified by ORBi

Boulanger, B., Ceccato, A., Chiap, P., & Hubert, P. (1997). Selecting Derringer’s desirability functions that guarantee Pareto optimality : an application to the optimization of a liquid chromatography separation [Poster presentation]. HPLC 97, Birmingham, United Kingdom.

Chapuzet, E., Mercier, N., Bervoas-Martin, S., Boulanger, B., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorge, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, J. C. (1997). Méthodes chromatographiques de dosage dans les milieux biologiques : stratégie de validation - Rapport d'une commission SFSTP. STP Pharma Pratiques, 7 (3), 169-194.
Peer reviewed

Ceccato, A., Boulanger, B., Chiap, P., Hubert, P., & Crommen, J. (1997). LC determination of mephobarbital enantiomers and phenobarbital in plasma using a precolumn with restricted access sorbent for sample clean-up [Poster presentation]. HPLC’ 97, Birmingham, United Kingdom.

Hubert, P., & Boulanger, B. (1997). Validation des méthodes d’analyse des médicaments dans les milieux biologiques.

Hubert, P., & Boulanger, B. (1997). Validation des méthodes d’analyse des médicaments dans les milieux biologiques.

Bervoas-Martin, S., Boulanger, B., Chapuzet, E., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, C. (1997). Méthodes chromatographiques de dosage dans les milieux biologiques : Stratégie de validation [Paper presentation]. XXIXth International seminar of SFSTP, Validation: quality enhancer, economic necessity, Montpellier, France.

Chiap, P., Ceccato, A., Miralles, B., Boulanger, B., Hubert, P., & Crommen, J. (1997). On-line combination of dialysis with trace enrichment on a cation-exchange precolumn for the automated LC determination of sotalol in plasma [Poster presentation]. HPLC 97, Birmingham, United Kingdom.

Bervoas-Martin, S., Boulanger, B., Chapuzet, E., Chevalier, P., Chiap, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, C. (1996). Méthodes chromatographiques de dosage dans les milieux biologiques : Stratégie de validation [Paper presentation]. Symposium de la SFSTP, Paris, France.

Bervoas-Martin, S., Boulanger, B., Chapuzet, E., Chevalier, P., Grandjean, D., Hubert, P., Lagorce, P., Lallier, M., Laparra, M. C., Laurentie, M., & Nivet, C. (1996). SFSTP guide on validation of bioanalytical methods : a proposal [Paper presentation]. Drug Information Association workshop, Statistical methodology in non-clinical and toxicological studies, Bruges, Belgium.

Boulanger, B., Ingebos, A.-M., Lahak, M., Machado, A., & Richelle, M. (1987). Variabilité comportementale et conditionnement operant chez l'animal: Revue critique. Année Psychologique, 87, 417-734.
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